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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1621 to 1650 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1621
NDFQKQQKQA
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1622
NFNYNNNLQG
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1623
NHVTLSQPKI
10
Non-amyloid
Beta-2-microglobulin
P61769
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1624
NITIKQHTVT
10
Non-amyloid
Major prion protein (PrP)
P04156
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1625
NLQGYQAGFQ
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1626
NQNNFVHDCV
10
Non-amyloid
Major prion protein (PrP)
P04156
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1627
NSRYWCNDGK
10
Non-amyloid
Lysozyme C
P61626
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1628
PDAGYQQQYN
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nature. 2005 Jun 9;435(7043):765-72.
15944694
CPAD
P-1629
PGGGKVYKPV
10
Non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
AmyLoad
P-1630
PQGGRGNYKN
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1631
PQGGYQQQFN
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nature. 2005 Jun 9;435(7043):765-72.
15944694
CPAD
P-1632
PVQTEEKTEE
10
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
AmyLoad
P-1633
QGGGTHSQWN
10
Non-amyloid
Major prion protein (PrP)
P04156
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1634
QGGYQQYNPQ
10
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
AmyLoad
P-1635
QHTVTTTTKG
10
Non-amyloid
Major prion protein (PrP)
P04156
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1636
QQQYNPQGGY
10
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
AmyLoad
P-1637
QVYSRHPAEN
10
Non-amyloid
Beta-2-microglobulin
P61769
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1638
RCELARTLKR
10
Amyloid
Lysozyme C
P61626
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
CPAD, AmyLoad
P-1639
RCQNRDVRQY
10
Non-amyloid
Lysozyme C
P61626
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1640
RENMHRYPNQ
10
Non-amyloid
Major prion protein (PrP)
P04156
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1641
RLANFLVHSS
10
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
J Mol Biol. 2002 Oct 4;322(5):1013-24.
12367525
CPAD
P-1642
RSTDYGIFQI
10
Non-amyloid
Lysozyme C
P61626
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1643
RTLKRLGMDG
10
Non-amyloid
Lysozyme C
P61626
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1644
RTPKIQVYSR
10
Non-amyloid
Beta-2-microglobulin
P61769
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1645
RYPNQVYYRP
10
Non-amyloid
Major prion protein (PrP)
P04156
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1646
RYQGYQAYNA
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1647
SCSALLQDNI
10
Non-amyloid
Lysozyme C
P61626
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1648
SDIEVDLLKN
10
Non-amyloid
Beta-2-microglobulin
P61769
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1649
SEFSVPSGEK
10
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1650
SGFHPSDIEV
10
Non-amyloid
Beta-2-microglobulin
P61769
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
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Entry: P-1621 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1621
Peptide:
NDFQKQQKQA
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
127-136
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
20.0
NuAPRpred:
-1.61
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-86.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.69
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1622 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1622
Peptide:
NFNYNNNLQG
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
103-112
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
30.0
NuAPRpred:
0.32
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-44.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.99
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1623 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1623
Peptide:
NHVTLSQPKI
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
103-112
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
40.0
NuAPRpred:
-2.01
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-16.6
Area of the profile Above Threshold (AGGRESCAN):
0.71
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1624 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1624
Peptide:
NITIKQHTVT
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
181-190
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
30.0
NuAPRpred:
-0.84
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-7.6
Area of the profile Above Threshold (AGGRESCAN):
0.88
Best Energy Score (PASTA 2.0):
-4.0
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1625 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1625
Peptide:
NLQGYQAGFQ
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
109-118
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
40.0
NuAPRpred:
-1.37
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.2
Area of the profile Above Threshold (AGGRESCAN):
0.24
Best Energy Score (PASTA 2.0):
0.68
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1626 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1626
Peptide:
NQNNFVHDCV
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
171-180
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
40.0
NuAPRpred:
1.06
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-40.0
Area of the profile Above Threshold (AGGRESCAN):
0.44
Best Energy Score (PASTA 2.0):
-3.4
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1627 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1627
Peptide:
NSRYWCNDGK
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
78-87
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
30.0
NuAPRpred:
-0.12
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-46.9
Area of the profile Above Threshold (AGGRESCAN):
0.34
Best Energy Score (PASTA 2.0):
-1.68
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1628 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1628
Peptide:
PDAGYQQQYN
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
65-74
Literature
PMID:
15944694
Reference:
Nature. 2005 Jun 9;435(7043):765-72.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
40.0
NuAPRpred:
-1.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.82
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1629 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1629
Peptide:
PGGGKVYKPV
Length:
10
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-1.99
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-10.8
Area of the profile Above Threshold (AGGRESCAN):
1.13
Best Energy Score (PASTA 2.0):
-0.93
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1630 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1630
Peptide:
PQGGRGNYKN
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
94-103
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
20.0
NuAPRpred:
-2.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-71.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.71
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1631 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1631
Peptide:
PQGGYQQQFN
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
84-93
Literature
PMID:
15944694
Reference:
Nature. 2005 Jun 9;435(7043):765-72.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
30.0
NuAPRpred:
-1.37
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-56.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.81
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1632 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1632
Peptide:
PVQTEEKTEE
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
199-208
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
5
Hydrophobicity:
20.0
NuAPRpred:
-2.54
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-75.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.05
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1633 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1633
Peptide:
QGGGTHSQWN
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
91-100
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
10.0
NuAPRpred:
-2.33
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.32
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1634 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1634
Peptide:
QGGYQQYNPQ
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
76-85
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
30.0
NuAPRpred:
-2.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-47.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.09
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1635 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1635
Peptide:
QHTVTTTTKG
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
186-195
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
10.0
NuAPRpred:
-1.81
Tango:
1.04
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.3
Area of the profile Above Threshold (AGGRESCAN):
0.46
Best Energy Score (PASTA 2.0):
-3.74
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1636 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1636
Peptide:
QQQYNPQGGY
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
70-79
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
30.0
NuAPRpred:
-3.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-60.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.69
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1637 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1637
Peptide:
QVYSRHPAEN
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
28-37
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
40.0
NuAPRpred:
-2.85
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-43.6
Area of the profile Above Threshold (AGGRESCAN):
0.08
Best Energy Score (PASTA 2.0):
-1.32
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1638 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1638
Peptide:
RCELARTLKR
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
23-32
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
3
Absolute Charge:
5
Hydrophobicity:
40.0
NuAPRpred:
-1.7
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.8
Area of the profile Above Threshold (AGGRESCAN):
0.28
Best Energy Score (PASTA 2.0):
-0.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1639 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1639
Peptide:
RCQNRDVRQY
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
133-142
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
30.0
NuAPRpred:
-1.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-68.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.5
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1640 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1640
Peptide:
RENMHRYPNQ
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
151-160
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
30.0
NuAPRpred:
-2.64
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.16
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1641 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1641
Peptide:
RLANFLVHSS
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
44-53
Literature
PMID:
12367525
Reference:
J Mol Biol. 2002 Oct 4;322(5):1013-24.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
1.89
Tango:
53.4
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.8
Area of the profile Above Threshold (AGGRESCAN):
2.97
Best Energy Score (PASTA 2.0):
-3.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1642 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1642
Peptide:
RSTDYGIFQI
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
68-77
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
40.0
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.5
Area of the profile Above Threshold (AGGRESCAN):
3.24
Best Energy Score (PASTA 2.0):
-3.4
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1643 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1643
Peptide:
RTLKRLGMDG
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
28-37
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
30.0
NuAPRpred:
-1.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.7
Area of the profile Above Threshold (AGGRESCAN):
0.14
Best Energy Score (PASTA 2.0):
-0.08
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1644 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1644
Peptide:
RTPKIQVYSR
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
23-32
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
3
Absolute Charge:
3
Hydrophobicity:
40.0
NuAPRpred:
-2.02
Tango:
1.97
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-7.2
Area of the profile Above Threshold (AGGRESCAN):
1.45
Best Energy Score (PASTA 2.0):
-2.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1645 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1645
Peptide:
RYPNQVYYRP
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
156-165
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
60.0
NuAPRpred:
-2.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-10.8
Area of the profile Above Threshold (AGGRESCAN):
1.09
Best Energy Score (PASTA 2.0):
-2.43
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1646 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1646
Peptide:
RYQGYQAYNA
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
28-37
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-1.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-27.9
Area of the profile Above Threshold (AGGRESCAN):
0.12
Best Energy Score (PASTA 2.0):
-0.57
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1647 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1647
Peptide:
SCSALLQDNI
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
98-107
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-16.2
Area of the profile Above Threshold (AGGRESCAN):
1.18
Best Energy Score (PASTA 2.0):
-0.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1648 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1648
Peptide:
SDIEVDLLKN
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
53-62
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
40.0
NuAPRpred:
0.32
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.3
Area of the profile Above Threshold (AGGRESCAN):
0.91
Best Energy Score (PASTA 2.0):
-2.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1649 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1649
Peptide:
SEFSVPSGEK
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
17-26
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
30.0
NuAPRpred:
-2.74
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.0
Area of the profile Above Threshold (AGGRESCAN):
1.08
Best Energy Score (PASTA 2.0):
-0.11
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1650 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1650
Peptide:
SGFHPSDIEV
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
48-57
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
40.0
NuAPRpred:
-2.74
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.13
Aggregate Orientation (PASTA 2.0):
Parallel
