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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1771 to 1800 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1771
EYSAMRDQYMRTGEG
15
Non-amyloid
GTPase HRas (H-Ras-1) (Transforming protein p21)
P08642
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1772
FNNGDCFILDLGNNI
15
Amyloid
Gelsolin (AGEL)
P06396
No
FEBS Lett. 1995 Sep 4;371(2):110-4.
7672107
CPAD
P-1773
FNNGNCFILDLGNNI
15
Amyloid
Gelsolin (AGEL)
P06396
D214N
FEBS Lett. 1995 Sep 4;371(2):110-4.
7672107
CPAD
P-1774
FNNGYCFILDLGNNI
15
Amyloid
Gelsolin (AGEL)
P06396
D214Y
FEBS Lett. 1995 Sep 4;371(2):110-4.
7672107
CPAD
P-1775
HPETLEKFDRFKHLK
15
Non-amyloid
Myoglobin
P02185
No
Protein Sci. 1997 Mar;6(3):706-16.
9070453
AmyLoad
P-1776
LEVLLGSGDGSLVFV
15
Amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
CPAD, AmyLoad
P-1777
MLSNTTAIAEAWARL
15
Amyloid
Tubulin alpha-1A chain (Alpha-tubulin 3)
Q71U36
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1778
PEDKVNSMKSWLSKV
15
Non-amyloid
Acylphosphatase-2
P14621
No
Nat Struct Biol. 2002 Feb;9(2):137-43.
11799398
AmyLoad
P-1779
PTGKDEYACRVNHVT
15
Non-amyloid
Beta-2-microglobulin
P61769
E94G
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
12488093
AmyLoad
P-1780
RFRAVTSAYYRGAVG
15
Non-amyloid
Ras-related protein RABA5e (AtRABA5e) (Ras-related protein Ara-1)
P19892
No
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1781
RPDFSLEPPYTGPSK
15
Non-amyloid
Pancreatic trypsin inhibitor (Aprotinin)
P00974
C40S, C49S
J Mol Biol. 1993 Dec 5;234(3):861-78.
7504737
AmyLoad
P-1782
RSFFSFLGEAFDGAR
15
Amyloid
FEBS Lett. 1995 Sep 4;371(2):110-4.
7672107
CPAD
P-1783
VHHPKLVFFAEDVGS
15
Amyloid
Amyloid-beta precursor protein (APP)
P05067
Q686P
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1784
VHHQKLVFFAEDVGS
15
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1785
VHHQKLVPFAEDVGS
15
Non-amyloid
Amyloid-beta precursor protein (APP)
P05067
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
AmyLoad
P-1786
VHHQPLVFFAEDVGS
15
Amyloid
Amyloid-beta precursor protein (APP)
P05067
K687P
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1787
VHPQKLVFFAEDVGS
15
Amyloid
Amyloid-beta precursor protein (APP)
P05067
H685P
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1788
VPHQKLVFFAEDVGS
15
Amyloid
Amyloid-beta precursor protein (APP)
P05067
H684P
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1789
YKMTQTELATKAGVK
15
Non-amyloid
Regulatory protein cro (Antirepressor)
P03036
L15Y
Protein Sci. 1999 Aug;8(8):1675-88.
10452612
AmyLoad
P-1790
AKNVDYCKEWLVNHIK
16
Non-amyloid
Myohemerythrin (MHr)
P02247
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
AmyLoad
P-1791
AVVGGLGGYMLGSAMS
16
Amyloid
Major prion protein (PrP)
P04156
No
J Mol Biol. 1997 Dec 5;274(3):381-93.
9405147
CPAD
P-1792
DCVNITIKQHTVTTTT
16
Amyloid
Major prion protein (PrP)
P04156
No
J Neurosci Res. 2000 Oct 15;62(2):293-301.
11020222
CPAD
P-1793
DVAGHGQDILIRLFKS
16
Amyloid
Myoglobin
P02185
No
Protein Sci. 1997 Mar;6(3):706-16.
9070453
CPAD, AmyLoad
P-1794
DWWKVEVNDRQGFVPA
16
Amyloid
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Q13813
No
J Mol Biol. 1996 Jan 26;255(3):507-21.
8568894
CPAD, AmyLoad
P-1795
DYFLFRDGDILGKYVD
16
Amyloid
heat shock protein, mitochondrial (Hsp10)
P26772
No
J Mol Biol. 2008 Apr 11;377(5):1593-606.
18329043
CPAD
P-1796
GEWTYDDATKTFTVTE
16
Amyloid
Immunoglobulin G-binding protein G (IgG-binding protein G)
P06654
Eur J Biochem. 1995 Jun 1;230(2):634-49.
7607238
CPAD, AmyLoad
P-1797
GSNKGAAIGLMVGGVV
16
Amyloid
Amyloid-beta precursor protein (APP)
P05067
I32A
Biophys Chem. 2016 Nov 11. pii: S0301-4622(16)30296-4
27856006
CPAD
P-1798
GSNKGAIIGLMVAGVV
16
Amyloid
Amyloid-beta precursor protein (APP)
P05067
G37A
Biophys Chem. 2016 Nov 11. pii: S0301-4622(16)30296-4
27856006
CPAD
P-1799
GSNKGAIIGLMVGGVV
16
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biophys Chem. 2016 Nov 11. pii: S0301-4622(16)30296-4
27856006
CPAD
P-1800
GSTDYGILQINSRWWC
16
Amyloid
Lysozyme C
P19849
No
J Mol Biol. 2000 Jul 14;300(3):541-9.
10884350
AmyLoad
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Entry: P-1771 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
E
Y
K
L
V
V
V
G
A
G
G
V
G
K
S
A
L
T
I
Q
L
I
Q
N
H
F
V
D
E
Y
D
P
T
I
E
D
S
Y
R
K
Q
V
V
I
D
G
E
T
C
L
L
D
I
L
D
T
A
G
60
61
Q
E
E
Y
S
A
M
R
D
Q
Y
M
R
T
G
E
G
F
L
C
V
F
A
I
N
N
T
K
S
F
E
D
I
H
Q
Y
R
E
Q
I
K
R
V
K
D
S
D
D
V
P
M
V
L
V
G
N
K
C
D
L
120
121
P
A
R
T
V
E
T
R
Q
A
Q
D
L
A
R
S
Y
G
I
P
Y
I
E
T
S
A
K
T
R
Q
G
V
E
D
A
F
Y
T
L
V
R
E
I
R
Q
H
K
L
R
K
L
N
P
P
D
E
S
G
P
G
180
181
C
M
N
C
K
C
V
I
S
189
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1771
Peptide:
EYSAMRDQYMRTGEG
Length:
15
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P08642
UniProt Name:
RASH_CHICK
Protein Name:
GTPase HRas (H-Ras-1) (Transforming protein p21)
Position:
63-77
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
33.33
NuAPRpred:
-5.92
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-40.6
Area of the profile Above Threshold (AGGRESCAN):
0.25
Best Energy Score (PASTA 2.0):
-1.92
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1772 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1772
Peptide:
FNNGDCFILDLGNNI
Length:
15
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
210-224
Literature
PMID:
7672107
Reference:
FEBS Lett. 1995 Sep 4;371(2):110-4.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
46.67
NuAPRpred:
0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-10.9
Area of the profile Above Threshold (AGGRESCAN):
3.33
Best Energy Score (PASTA 2.0):
-3.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1773 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1773
Peptide:
FNNGNCFILDLGNNI
Length:
15
Classification:
Amyloid
Mutation(s):
D214N
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
210-224
Literature
PMID:
7672107
Reference:
FEBS Lett. 1995 Sep 4;371(2):110-4.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
46.67
NuAPRpred:
3.13
Tango:
1.01
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-7.4
Area of the profile Above Threshold (AGGRESCAN):
3.54
Best Energy Score (PASTA 2.0):
-3.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1774 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1774
Peptide:
FNNGYCFILDLGNNI
Length:
15
Classification:
Amyloid
Mutation(s):
D214Y
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
210-224
Literature
PMID:
7672107
Reference:
FEBS Lett. 1995 Sep 4;371(2):110-4.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
53.33
NuAPRpred:
3.95
Tango:
85.37
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.0
Area of the profile Above Threshold (AGGRESCAN):
4.88
Best Energy Score (PASTA 2.0):
-4.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1775 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
L
S
E
G
E
W
Q
L
V
L
H
V
W
A
K
V
E
A
D
V
A
G
H
G
Q
D
I
L
I
R
L
F
K
S
H
P
E
T
L
E
K
F
D
R
F
K
H
L
K
T
E
A
E
M
K
A
S
E
60
61
D
L
K
K
H
G
V
T
V
L
T
A
L
G
A
I
L
K
K
K
G
H
H
E
A
E
L
K
P
L
A
Q
S
H
A
T
K
H
K
I
P
I
K
Y
L
E
F
I
S
E
A
I
I
H
V
L
H
S
R
H
120
121
P
G
D
F
G
A
D
A
Q
G
A
M
N
K
A
L
E
L
F
R
K
D
I
A
A
K
Y
K
E
L
G
Y
Q
G
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1775
Peptide:
HPETLEKFDRFKHLK
Length:
15
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02185
UniProt Name:
MYG_PHYMC
Protein Name:
Myoglobin
Position:
37-51
Literature
PMID:
9070453
Reference:
Protein Sci. 1997 Mar;6(3):706-16.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
7
Hydrophobicity:
33.33
NuAPRpred:
-4.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.1
Area of the profile Above Threshold (AGGRESCAN):
0.22
Best Energy Score (PASTA 2.0):
-1.84
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1776 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1776
Peptide:
LEVLLGSGDGSLVFV
Length:
15
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
1-15
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
53.33
NuAPRpred:
-0.32
Tango:
2.08
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
32.2
Area of the profile Above Threshold (AGGRESCAN):
7.36
Best Energy Score (PASTA 2.0):
-5.65
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1777 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
E
C
I
S
I
H
V
G
Q
A
G
V
Q
I
G
N
A
C
W
E
L
Y
C
L
E
H
G
I
Q
P
D
G
Q
M
P
S
D
K
T
I
G
G
G
D
D
S
F
N
T
F
F
S
E
T
G
A
G
K
60
61
H
V
P
R
A
V
F
V
D
L
E
P
T
V
I
D
E
V
R
T
G
T
Y
R
Q
L
F
H
P
E
Q
L
I
T
G
K
E
D
A
A
N
N
Y
A
R
G
H
Y
T
I
G
K
E
I
I
D
L
V
L
D
120
121
R
I
R
K
L
A
D
Q
C
T
G
L
Q
G
F
L
V
F
H
S
F
G
G
G
T
G
S
G
F
T
S
L
L
M
E
R
L
S
V
D
Y
G
K
K
S
K
L
E
F
S
I
Y
P
A
P
Q
V
S
T
A
180
181
V
V
E
P
Y
N
S
I
L
T
T
H
T
T
L
E
H
S
D
C
A
F
M
V
D
N
E
A
I
Y
D
I
C
R
R
N
L
D
I
E
R
P
T
Y
T
N
L
N
R
L
I
G
Q
I
V
S
S
I
T
A
240
241
S
L
R
F
D
G
A
L
N
V
D
L
T
E
F
Q
T
N
L
V
P
Y
P
R
I
H
F
P
L
A
T
Y
A
P
V
I
S
A
E
K
A
Y
H
E
Q
L
S
V
A
E
I
T
N
A
C
F
E
P
A
N
300
301
Q
M
V
K
C
D
P
R
H
G
K
Y
M
A
C
C
L
L
Y
R
G
D
V
V
P
K
D
V
N
A
A
I
A
T
I
K
T
K
R
T
I
Q
F
V
D
W
C
P
T
G
F
K
V
G
I
N
Y
Q
P
P
360
361
T
V
V
P
G
G
D
L
A
K
V
Q
R
A
V
C
M
L
S
N
T
T
A
I
A
E
A
W
A
R
L
D
H
K
F
D
L
M
Y
A
K
R
A
F
V
H
W
Y
V
G
E
G
M
E
E
G
E
F
S
E
420
421
A
R
E
D
M
A
A
L
E
K
D
Y
E
E
V
G
V
D
S
V
E
G
E
G
E
E
E
G
E
E
Y
451
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1777
Peptide:
MLSNTTAIAEAWARL
Length:
15
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q71U36
UniProt Name:
TBA1A_HUMAN
Protein Name:
Tubulin alpha-1A chain (Alpha-tubulin 3)
Position:
377-391
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
60.0
NuAPRpred:
-1.96
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.7
Area of the profile Above Threshold (AGGRESCAN):
1.22
Best Energy Score (PASTA 2.0):
-1.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1778 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
T
A
Q
S
L
K
S
V
D
Y
E
V
F
G
R
V
Q
G
V
C
F
R
M
Y
T
E
D
E
A
R
K
I
G
V
V
G
W
V
K
N
T
S
K
G
T
V
T
G
Q
V
Q
G
P
E
D
K
V
N
60
61
S
M
K
S
W
L
S
K
V
G
S
P
S
S
R
I
D
R
T
N
F
S
N
E
K
T
I
S
K
L
E
Y
S
N
F
S
I
R
Y
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1778
Peptide:
PEDKVNSMKSWLSKV
Length:
15
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14621
UniProt Name:
ACYP2_HUMAN
Protein Name:
Acylphosphatase-2
Position:
55-69
Literature
PMID:
11799398
Reference:
Nat Struct Biol. 2002 Feb;9(2):137-43.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
40.0
NuAPRpred:
-2.73
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.5
Area of the profile Above Threshold (AGGRESCAN):
1.86
Best Energy Score (PASTA 2.0):
-1.66
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1779 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1779
Peptide:
PTGKDEYACRVNHVT
Length:
15
Classification:
Non-amyloid
Mutation(s):
E94G
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
92-106
Literature
PMID:
12488093
Reference:
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
40.0
NuAPRpred:
-1.85
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-37.6
Area of the profile Above Threshold (AGGRESCAN):
0.6
Best Energy Score (PASTA 2.0):
-3.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1780 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
S
D
D
E
G
R
E
E
Y
L
F
K
I
V
V
I
G
D
S
A
V
G
K
S
N
L
L
S
R
Y
A
R
N
E
F
S
A
N
S
K
A
T
I
G
V
E
F
Q
T
Q
S
M
E
I
E
G
K
E
60
61
V
K
A
Q
I
W
D
T
A
G
Q
E
R
F
R
A
V
T
S
A
Y
Y
R
G
A
V
G
A
L
V
V
Y
D
I
T
R
R
T
T
F
E
S
V
G
R
W
L
D
E
L
K
I
H
S
D
T
T
V
A
R
120
121
M
L
V
G
N
K
C
D
L
E
N
I
R
A
V
S
V
E
E
G
K
A
L
A
E
E
E
G
L
F
F
V
E
T
S
A
L
D
S
T
N
V
K
T
A
F
E
M
V
I
L
D
I
Y
N
N
V
S
R
K
180
181
Q
L
N
S
D
T
Y
K
D
E
L
T
V
N
R
V
S
L
V
K
D
D
N
S
A
S
K
Q
S
S
G
F
S
C
C
S
S
T
218
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1780
Peptide:
RFRAVTSAYYRGAVG
Length:
15
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P19892
UniProt Name:
RAA5E_ARATH
Protein Name:
Ras-related protein RABA5e (AtRABA5e) (Ras-related protein Ara-1)
Position:
73-87
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
3
Absolute Charge:
3
Hydrophobicity:
53.33
NuAPRpred:
-3.77
Tango:
0.71
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.0
Area of the profile Above Threshold (AGGRESCAN):
2.3
Best Energy Score (PASTA 2.0):
-2.16
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1781 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
M
S
R
L
C
L
S
V
A
L
L
V
L
L
G
T
L
A
A
S
T
P
G
C
D
T
S
N
Q
A
K
A
Q
R
P
D
F
C
L
E
P
P
Y
T
G
P
C
K
A
R
I
I
R
Y
F
Y
N
A
60
61
K
A
G
L
C
Q
T
F
V
Y
G
G
C
R
A
K
R
N
N
F
K
S
A
E
D
C
M
R
T
C
G
G
A
I
G
P
W
E
N
L
100
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1781
Peptide:
RPDFSLEPPYTGPSK
Length:
15
Classification:
Non-amyloid
Mutation(s):
C40S, C49S
Structure(s):
No structures
Protein Information
UniProt ID:
P00974
UniProt Name:
BPT1_BOVIN
Protein Name:
Pancreatic trypsin inhibitor (Aprotinin)
Position:
36-50
Literature
PMID:
7504737
Reference:
J Mol Biol. 1993 Dec 5;234(3):861-78.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
46.67
NuAPRpred:
-6.08
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-23.9
Area of the profile Above Threshold (AGGRESCAN):
0.39
Best Energy Score (PASTA 2.0):
0.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1782 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1782
Peptide:
RSFFSFLGEAFDGAR
Length:
15
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
7672107
Reference:
FEBS Lett. 1995 Sep 4;371(2):110-4.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
46.67
NuAPRpred:
-0.57
Tango:
379.08
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.0
Area of the profile Above Threshold (AGGRESCAN):
4.36
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1783 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1783
Peptide:
VHHPKLVFFAEDVGS
Length:
15
Classification:
Amyloid
Mutation(s):
Q686P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
53.33
NuAPRpred:
-1.56
Tango:
432.58
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.3
Area of the profile Above Threshold (AGGRESCAN):
4.16
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1784 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1784
Peptide:
VHHQKLVFFAEDVGS
Length:
15
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
46.67
NuAPRpred:
1.37
Tango:
432.76
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.8
Area of the profile Above Threshold (AGGRESCAN):
3.82
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1785 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1785
Peptide:
VHHQKLVPFAEDVGS
Length:
15
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
46.67
NuAPRpred:
-3.68
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-17.7
Area of the profile Above Threshold (AGGRESCAN):
1.19
Best Energy Score (PASTA 2.0):
-1.83
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1786 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1786
Peptide:
VHHQPLVFFAEDVGS
Length:
15
Classification:
Amyloid
Mutation(s):
K687P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
53.33
NuAPRpred:
-2.19
Tango:
274.51
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.2
Area of the profile Above Threshold (AGGRESCAN):
4.06
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1787 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1787
Peptide:
VHPQKLVFFAEDVGS
Length:
15
Classification:
Amyloid
Mutation(s):
H685P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
53.33
NuAPRpred:
-0.9
Tango:
431.94
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.8
Area of the profile Above Threshold (AGGRESCAN):
3.94
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1788 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1788
Peptide:
VPHQKLVFFAEDVGS
Length:
15
Classification:
Amyloid
Mutation(s):
H684P
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-697
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
53.33
NuAPRpred:
0.01
Tango:
432.26
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.1
Area of the profile Above Threshold (AGGRESCAN):
3.82
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1789 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
T
L
S
E
R
L
K
K
R
R
I
A
L
K
M
T
Q
T
E
L
A
T
K
A
G
V
K
Q
Q
S
I
Q
L
I
E
A
G
V
T
K
R
P
R
F
L
F
E
I
A
M
A
L
N
C
D
P
V
W
60
61
L
Q
Y
G
T
K
R
G
K
A
A
71
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1789
Peptide:
YKMTQTELATKAGVK
Length:
15
Classification:
Non-amyloid
Mutation(s):
L15Y
Structure(s):
No structures
Protein Information
UniProt ID:
P03036
UniProt Name:
RCRO_BP434
Protein Name:
Regulatory protein cro (Antirepressor)
Position:
15-29
Literature
PMID:
10452612
Reference:
Protein Sci. 1999 Aug;8(8):1675-88.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
40.0
NuAPRpred:
-4.84
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.8
Area of the profile Above Threshold (AGGRESCAN):
0.07
Best Energy Score (PASTA 2.0):
-1.45
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1790 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
G
W
E
I
P
E
P
Y
V
W
D
E
S
F
R
V
F
Y
E
Q
L
D
E
E
H
K
K
I
F
K
G
I
F
D
C
I
R
D
N
S
A
P
N
L
A
T
L
V
K
V
T
T
N
H
F
T
H
E
E
A
60
61
M
M
D
A
A
K
Y
S
E
V
V
P
H
K
K
M
H
K
D
F
L
E
K
I
G
G
L
S
A
P
V
D
A
K
N
V
D
Y
C
K
E
W
L
V
N
H
I
K
G
T
D
F
K
Y
K
G
K
L
118
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1790
Peptide:
AKNVDYCKEWLVNHIK
Length:
16
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02247
UniProt Name:
HEMTM_THEHE
Protein Name:
Myohemerythrin (MHr)
Position:
93-108
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
50.0
NuAPRpred:
4.51
Tango:
6.61
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-8.4
Area of the profile Above Threshold (AGGRESCAN):
2.02
Best Energy Score (PASTA 2.0):
-5.53
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1791 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1791
Peptide:
AVVGGLGGYMLGSAMS
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
120-135
Literature
PMID:
9405147
Reference:
J Mol Biol. 1997 Dec 5;274(3):381-93.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
56.25
NuAPRpred:
-1.48
Tango:
2.59
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.8
Area of the profile Above Threshold (AGGRESCAN):
4.84
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1792 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1792
Peptide:
DCVNITIKQHTVTTTT
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
178-193
Literature
PMID:
11020222
Reference:
J Neurosci Res. 2000 Oct 15;62(2):293-301.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
31.25
NuAPRpred:
0.25
Tango:
25.88
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.2
Area of the profile Above Threshold (AGGRESCAN):
2.52
Best Energy Score (PASTA 2.0):
-6.08
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1793 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
V
L
S
E
G
E
W
Q
L
V
L
H
V
W
A
K
V
E
A
D
V
A
G
H
G
Q
D
I
L
I
R
L
F
K
S
H
P
E
T
L
E
K
F
D
R
F
K
H
L
K
T
E
A
E
M
K
A
S
E
60
61
D
L
K
K
H
G
V
T
V
L
T
A
L
G
A
I
L
K
K
K
G
H
H
E
A
E
L
K
P
L
A
Q
S
H
A
T
K
H
K
I
P
I
K
Y
L
E
F
I
S
E
A
I
I
H
V
L
H
S
R
H
120
121
P
G
D
F
G
A
D
A
Q
G
A
M
N
K
A
L
E
L
F
R
K
D
I
A
A
K
Y
K
E
L
G
Y
Q
G
154
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1793
Peptide:
DVAGHGQDILIRLFKS
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02185
UniProt Name:
MYG_PHYMC
Protein Name:
Myoglobin
Position:
21-36
Literature
PMID:
9070453
Reference:
Protein Sci. 1997 Mar;6(3):706-16.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
43.75
NuAPRpred:
-1.32
Tango:
18.92
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.3
Area of the profile Above Threshold (AGGRESCAN):
4.01
Best Energy Score (PASTA 2.0):
-5.1
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1794 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
P
S
G
V
K
V
L
E
T
A
E
D
I
Q
E
R
R
Q
Q
V
L
D
R
Y
H
R
F
K
E
L
S
T
L
R
R
Q
K
L
E
D
S
Y
R
F
Q
F
F
Q
R
D
A
E
E
L
E
K
W
I
60
61
Q
E
K
L
Q
I
A
S
D
E
N
Y
K
D
P
T
N
L
Q
G
K
L
Q
K
H
Q
A
F
E
A
E
V
Q
A
N
S
G
A
I
V
K
L
D
E
T
G
N
L
M
I
S
E
G
H
F
A
S
E
T
I
120
121
R
T
R
L
M
E
L
H
R
Q
W
E
L
L
L
E
K
M
R
E
K
G
I
K
L
L
Q
A
Q
K
L
V
Q
Y
L
R
E
C
E
D
V
M
D
W
I
N
D
K
E
A
I
V
T
S
E
E
L
G
Q
D
180
181
L
E
H
V
E
V
L
Q
K
K
F
E
E
F
Q
T
D
M
A
A
H
E
E
R
V
N
E
V
N
Q
F
A
A
K
L
I
Q
E
Q
H
P
E
E
E
L
I
K
T
K
Q
D
E
V
N
A
A
W
Q
R
L
240
241
K
G
L
A
L
Q
R
Q
G
K
L
F
G
A
A
E
V
Q
R
F
N
R
D
V
D
E
T
I
S
W
I
K
E
K
E
Q
L
M
A
S
D
D
F
G
R
D
L
A
S
V
Q
A
L
L
R
K
H
E
G
L
300
301
E
R
D
L
A
A
L
E
D
K
V
K
A
L
C
A
E
A
D
R
L
Q
Q
S
H
P
L
S
A
T
Q
I
Q
V
K
R
E
E
L
I
T
N
W
E
Q
I
R
T
L
A
A
E
R
H
A
R
L
N
D
S
360
361
Y
R
L
Q
R
F
L
A
D
F
R
D
L
T
S
W
V
T
E
M
K
A
L
I
N
A
D
E
L
A
S
D
V
A
G
A
E
A
L
L
D
R
H
Q
E
H
K
G
E
I
D
A
H
E
D
S
F
K
S
A
420
421
D
E
S
G
Q
A
L
L
A
A
G
H
Y
A
S
D
E
V
R
E
K
L
T
V
L
S
E
E
R
A
A
L
L
E
L
W
E
L
R
R
Q
Q
Y
E
Q
C
M
D
L
Q
L
F
Y
R
D
T
E
Q
V
D
480
481
N
W
M
S
K
Q
E
A
F
L
L
N
E
D
L
G
D
S
L
D
S
V
E
A
L
L
K
K
H
E
D
F
E
K
S
L
S
A
Q
E
E
K
I
T
A
L
D
E
F
A
T
K
L
I
Q
N
N
H
Y
A
540
541
M
E
D
V
A
T
R
R
D
A
L
L
S
R
R
N
A
L
H
E
R
A
M
R
R
R
A
Q
L
A
D
S
F
H
L
Q
Q
F
F
R
D
S
D
E
L
K
S
W
V
N
E
K
M
K
T
A
T
D
E
A
600
601
Y
K
D
P
S
N
L
Q
G
K
V
Q
K
H
Q
A
F
E
A
E
L
S
A
N
Q
S
R
I
D
A
L
E
K
A
G
Q
K
L
I
D
V
N
H
Y
A
K
D
E
V
A
A
R
M
N
E
V
I
S
L
W
660
661
K
K
L
L
E
A
T
E
L
K
G
I
K
L
R
E
A
N
Q
Q
Q
Q
F
N
R
N
V
E
D
I
E
L
W
L
Y
E
V
E
G
H
L
A
S
D
D
Y
G
K
D
L
T
N
V
Q
N
L
Q
K
K
H
720
721
A
L
L
E
A
D
V
A
A
H
Q
D
R
I
D
G
I
T
I
Q
A
R
Q
F
Q
D
A
G
H
F
D
A
E
N
I
K
K
K
Q
E
A
L
V
A
R
Y
E
A
L
K
E
P
M
V
A
R
K
Q
K
L
780
781
A
D
S
L
R
L
Q
Q
L
F
R
D
V
E
D
E
E
T
W
I
R
E
K
E
P
I
A
A
S
T
N
R
G
K
D
L
I
G
V
Q
N
L
L
K
K
H
Q
A
L
Q
A
E
I
A
G
H
E
P
R
I
840
841
K
A
V
T
Q
K
G
N
A
M
V
E
E
G
H
F
A
A
E
D
V
K
A
K
L
H
E
L
N
Q
K
W
E
A
L
K
A
K
A
S
Q
R
R
Q
D
L
E
D
S
L
Q
A
Q
Q
Y
F
A
D
A
N
900
901
E
A
E
S
W
M
R
E
K
E
P
I
V
G
S
T
D
Y
G
K
D
E
D
S
A
E
A
L
L
K
K
H
E
A
L
M
S
D
L
S
A
Y
G
S
S
I
Q
A
L
R
E
Q
A
Q
S
C
R
Q
Q
V
960
961
A
P
T
D
D
E
T
G
K
E
L
V
L
A
L
Y
D
Y
Q
E
K
S
P
R
E
V
T
M
K
K
G
D
I
L
T
L
L
N
S
T
N
K
D
W
W
K
V
E
V
N
D
R
Q
G
F
V
P
A
A
Y
1020
1021
V
K
K
L
D
P
A
Q
S
A
S
R
E
N
L
L
E
E
Q
G
S
I
A
L
R
Q
E
Q
I
D
N
Q
T
R
I
T
K
E
A
G
S
V
S
L
R
M
K
Q
V
E
E
L
Y
H
S
L
L
E
L
G
1080
1081
E
K
R
K
G
M
L
E
K
S
C
K
K
F
M
L
F
R
E
A
N
E
L
Q
Q
W
I
N
E
K
E
A
A
L
T
S
E
E
V
G
A
D
L
E
Q
V
E
V
L
Q
K
K
F
D
D
F
Q
K
D
L
1140
1141
K
A
N
E
S
R
L
K
D
I
N
K
V
A
E
D
L
E
S
E
G
L
M
A
E
E
V
Q
A
V
Q
Q
Q
E
V
Y
G
M
M
P
R
D
E
T
D
S
K
T
A
S
P
W
K
S
A
R
L
M
V
H
1200
1201
T
V
A
T
F
N
S
I
K
E
L
N
E
R
W
R
S
L
Q
Q
L
A
E
E
R
S
Q
L
L
G
S
A
H
E
V
Q
R
F
H
R
D
A
D
E
T
K
E
W
I
E
E
K
N
Q
A
L
N
T
D
N
1260
1261
Y
G
H
D
L
A
S
V
Q
A
L
Q
R
K
H
E
G
F
E
R
D
L
A
A
L
G
D
K
V
N
S
L
G
E
T
A
E
R
L
I
Q
S
H
P
E
S
A
E
D
L
Q
E
K
C
T
E
L
N
Q
A
1320
1321
W
S
S
L
G
K
R
A
D
Q
R
K
A
K
L
G
D
S
H
D
L
Q
R
F
L
S
D
F
R
D
L
M
S
W
I
N
G
I
R
G
L
V
S
S
D
E
L
A
K
D
V
T
G
A
E
A
L
L
E
R
1380
1381
H
Q
E
H
R
T
E
I
D
A
R
A
G
T
F
Q
A
F
E
Q
F
G
Q
Q
L
L
A
H
G
H
Y
A
S
P
E
I
K
Q
K
L
D
I
L
D
Q
E
R
A
D
L
E
K
A
W
V
Q
R
R
M
M
1440
1441
L
D
Q
C
L
E
L
Q
L
F
H
R
D
C
E
Q
A
E
N
W
M
A
A
R
E
A
F
L
N
T
E
D
K
G
D
S
L
D
S
V
E
A
L
I
K
K
H
E
D
F
D
K
A
I
N
V
Q
E
E
K
1500
1501
I
A
A
L
Q
A
F
A
D
Q
L
I
A
A
G
H
Y
A
K
G
D
I
S
S
R
R
N
E
V
L
D
R
W
R
R
L
K
A
Q
M
I
E
K
R
S
K
L
G
E
S
Q
T
L
Q
Q
F
S
R
D
V
1560
1561
D
E
I
E
A
W
I
S
E
K
L
Q
T
A
S
D
E
S
Y
K
D
P
T
N
I
Q
S
K
H
Q
K
H
Q
A
F
E
A
E
L
H
A
N
A
D
R
I
R
G
V
I
D
M
G
N
S
L
I
E
R
G
1620
1621
A
C
A
G
S
E
D
A
V
K
A
R
L
A
A
L
A
D
Q
W
Q
F
L
V
Q
K
S
A
E
K
S
Q
K
L
K
E
A
N
K
Q
Q
N
F
N
T
G
I
K
D
F
D
F
W
L
S
E
V
E
A
L
1680
1681
L
A
S
E
D
Y
G
K
D
L
A
S
V
N
N
L
L
K
K
H
Q
L
L
E
A
D
I
S
A
H
E
D
R
L
K
D
L
N
S
Q
A
D
S
L
M
T
S
S
A
F
D
T
S
Q
V
K
D
K
R
D
1740
1741
T
I
N
G
R
F
Q
K
I
K
S
M
A
A
S
R
R
A
K
L
N
E
S
H
R
L
H
Q
F
F
R
D
M
D
D
E
E
S
W
I
K
E
K
K
L
L
V
G
S
E
D
Y
G
R
D
L
T
G
V
Q
1800
1801
N
L
R
K
K
H
K
R
L
E
A
E
L
A
A
H
E
P
A
I
Q
G
V
L
D
T
G
K
K
L
S
D
D
N
T
I
G
K
E
E
I
Q
Q
R
L
A
Q
F
V
E
H
W
K
E
L
K
Q
L
A
A
1860
1861
A
R
G
Q
R
L
E
E
S
L
E
Y
Q
Q
F
V
A
N
V
E
E
E
E
A
W
I
N
E
K
M
T
L
V
A
S
E
D
Y
G
D
T
L
A
A
I
Q
G
L
L
K
K
H
E
A
F
E
T
D
F
T
1920
1921
V
H
K
D
R
V
N
D
V
C
T
N
G
Q
D
L
I
K
K
N
N
H
H
E
E
N
I
S
S
K
M
K
G
L
N
G
K
V
S
D
L
E
K
A
A
A
Q
R
K
A
K
L
D
E
N
S
A
F
L
Q
1980
1981
F
N
W
K
A
D
V
V
E
S
W
I
G
E
K
E
N
S
L
K
T
D
D
Y
G
R
D
L
S
S
V
Q
T
L
L
T
K
Q
E
T
F
D
A
G
L
Q
A
F
Q
Q
E
G
I
A
N
I
T
A
L
K
2040
2041
D
Q
L
L
A
A
K
H
V
Q
S
K
A
I
E
A
R
H
A
S
L
M
K
R
W
S
Q
L
L
A
N
S
A
A
R
K
K
K
L
L
E
A
Q
S
H
F
R
K
V
E
D
L
F
L
T
F
A
K
K
A
2100
2101
S
A
F
N
S
W
F
E
N
A
E
E
D
L
T
D
P
V
R
C
N
S
L
E
E
I
K
A
L
R
E
A
H
D
A
F
R
S
S
L
S
S
A
Q
A
D
F
N
Q
L
A
E
L
D
R
Q
I
K
S
F
2160
2161
R
V
A
S
N
P
Y
T
W
F
T
M
E
A
L
E
E
T
W
R
N
L
Q
K
I
I
K
E
R
E
L
E
L
Q
K
E
Q
R
R
Q
E
E
N
D
K
L
R
Q
E
F
A
Q
H
A
N
A
F
H
Q
W
2220
2221
I
Q
E
T
R
T
Y
L
L
D
G
S
C
M
V
E
E
S
G
T
L
E
S
Q
L
E
A
T
K
R
K
H
Q
E
I
R
A
M
R
S
Q
L
K
K
I
E
D
L
G
A
A
M
E
E
A
L
I
L
D
N
2280
2281
K
Y
T
E
H
S
T
V
G
L
A
Q
Q
W
D
Q
L
D
Q
L
G
M
R
M
Q
H
N
L
E
Q
Q
I
Q
A
R
N
T
T
G
V
T
E
E
A
L
K
E
F
S
M
M
F
K
H
F
D
K
D
K
S
2340
2341
G
R
L
N
H
Q
E
F
K
S
C
L
R
S
L
G
Y
D
L
P
M
V
E
E
G
E
P
D
P
E
F
E
A
I
L
D
T
V
D
P
N
R
D
G
H
V
S
L
Q
E
Y
M
A
F
M
I
S
R
E
T
2400
2401
E
N
V
K
S
S
E
E
I
E
S
A
F
R
A
L
S
S
E
G
K
P
Y
V
T
K
E
E
L
Y
Q
N
L
T
R
E
Q
A
D
Y
C
V
S
H
M
K
P
Y
V
D
G
K
G
R
E
L
P
T
A
F
2460
2461
D
Y
V
E
F
T
R
S
L
F
V
N
2472
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1794
Peptide:
DWWKVEVNDRQGFVPA
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13813
UniProt Name:
SPTN1_HUMAN
Protein Name:
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin)
Position:
1003-1018
Literature
PMID:
8568894
Reference:
J Mol Biol. 1996 Jan 26;255(3):507-21.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
50.0
NuAPRpred:
-2.33
Tango:
3.05
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.0
Area of the profile Above Threshold (AGGRESCAN):
2.15
Best Energy Score (PASTA 2.0):
-2.62
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1795 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
Q
A
F
R
K
F
L
P
L
F
D
R
V
L
V
E
R
S
A
A
E
T
V
T
K
G
G
I
M
L
P
E
K
S
Q
G
K
V
L
Q
A
T
V
V
A
V
G
S
G
G
K
G
K
G
G
E
I
60
61
Q
P
V
S
V
K
V
G
D
K
V
L
L
P
E
Y
G
G
T
K
V
V
L
D
D
K
D
Y
F
L
F
R
D
G
D
I
L
G
K
Y
V
D
102
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1795
Peptide:
DYFLFRDGDILGKYVD
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P26772
UniProt Name:
CH10_RAT
Protein Name:
heat shock protein, mitochondrial (Hsp10)
Position:
87-102
Literature
PMID:
18329043
Reference:
J Mol Biol. 2008 Apr 11;377(5):1593-606.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
6
Hydrophobicity:
50.0
NuAPRpred:
-3.77
Tango:
2.13
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.4
Area of the profile Above Threshold (AGGRESCAN):
3.92
Best Energy Score (PASTA 2.0):
-3.25
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1796 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
E
K
E
K
K
V
K
Y
F
L
R
K
S
A
F
G
L
A
S
V
S
A
A
F
L
V
G
S
T
V
F
A
V
D
S
P
I
E
D
T
P
I
I
R
N
G
G
E
L
T
N
L
L
G
N
S
E
T
T
60
61
L
A
L
R
N
E
E
S
A
T
A
D
L
T
A
A
A
V
A
D
T
V
A
A
A
A
A
E
N
A
G
A
A
A
W
E
A
A
A
A
A
D
A
L
A
K
A
K
A
D
A
L
K
E
F
N
K
Y
G
V
120
121
S
D
Y
Y
K
N
L
I
N
N
A
K
T
V
E
G
I
K
D
L
Q
A
Q
V
V
E
S
A
K
K
A
R
I
S
E
A
T
D
G
L
S
D
F
L
K
S
Q
T
P
A
E
D
T
V
K
S
I
E
L
A
180
181
E
A
K
V
L
A
N
R
E
L
D
K
Y
G
V
S
D
Y
H
K
N
L
I
N
N
A
K
T
V
E
G
V
K
E
L
I
D
E
I
L
A
A
L
P
K
T
D
T
Y
K
L
I
L
N
G
K
T
L
K
G
240
241
E
T
T
T
E
A
V
D
A
A
T
A
E
K
V
F
K
Q
Y
A
N
D
N
G
V
D
G
E
W
T
Y
D
D
A
T
K
T
F
T
V
T
E
K
P
E
V
I
D
A
S
E
L
T
P
A
V
T
T
Y
K
300
301
L
V
I
N
G
K
T
L
K
G
E
T
T
T
K
A
V
D
A
E
T
A
E
K
A
F
K
Q
Y
A
N
D
N
G
V
D
G
V
W
T
Y
D
D
A
T
K
T
F
T
V
T
E
M
V
T
E
V
P
G
D
360
361
A
P
T
E
P
E
K
P
E
A
S
I
P
L
V
P
L
T
P
A
T
P
I
A
K
D
D
A
K
K
D
D
T
K
K
E
D
A
K
K
P
E
A
K
K
D
D
A
K
K
A
E
T
L
P
T
T
G
E
G
420
421
S
N
P
F
F
T
A
A
A
L
A
V
M
A
G
A
G
A
L
A
V
A
S
K
R
K
E
D
448
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1796
Peptide:
GEWTYDDATKTFTVTE
Length:
16
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P06654
UniProt Name:
SPG1_STRSG
Protein Name:
Immunoglobulin G-binding protein G (IgG-binding protein G)
Position:
Literature
PMID:
7607238
Reference:
Eur J Biochem. 1995 Jun 1;230(2):634-49.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-3
Absolute Charge:
5
Hydrophobicity:
31.25
NuAPRpred:
-5.17
Tango:
25.35
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-20.6
Area of the profile Above Threshold (AGGRESCAN):
1.62
Best Energy Score (PASTA 2.0):
-4.59
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1797 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
40
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1797
Peptide:
GSNKGAAIGLMVGGVV
Length:
16
Classification:
Amyloid
Mutation(s):
I32A
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
696-711
Literature
PMID:
27856006
Reference:
Biophys Chem. 2016 Nov 11. pii: S0301-4622(16)30296-4
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
1.04
Tango:
104.64
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.7
Area of the profile Above Threshold (AGGRESCAN):
5.56
Best Energy Score (PASTA 2.0):
-4.92
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1798 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
40
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1798
Peptide:
GSNKGAIIGLMVAGVV
Length:
16
Classification:
Amyloid
Mutation(s):
G37A
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
696-711
Literature
PMID:
27856006
Reference:
Biophys Chem. 2016 Nov 11. pii: S0301-4622(16)30296-4
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
56.25
NuAPRpred:
3.55
Tango:
811.21
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
25.1
Area of the profile Above Threshold (AGGRESCAN):
7.65
Best Energy Score (PASTA 2.0):
-7.72
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1799 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
40
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1799
Peptide:
GSNKGAIIGLMVGGVV
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
696-711
Literature
PMID:
27856006
Reference:
Biophys Chem. 2016 Nov 11. pii: S0301-4622(16)30296-4
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
3.51
Tango:
471.64
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
21.4
Area of the profile Above Threshold (AGGRESCAN):
7.05
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1800 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
K
V
Y
G
R
C
E
L
A
A
A
M
K
R
L
G
L
D
N
Y
R
G
Y
S
L
G
N
W
V
C
A
A
K
F
E
S
N
F
N
T
H
A
T
N
R
N
T
D
G
S
T
D
Y
G
I
L
Q
I
N
S
60
61
R
W
W
C
N
D
G
R
T
P
G
S
R
N
L
C
N
I
P
C
S
A
L
L
S
S
D
I
T
A
S
V
N
C
A
K
K
I
V
S
D
R
N
G
M
N
A
W
V
A
W
R
N
R
C
K
G
T
D
V
120
121
H
A
W
I
R
G
C
R
L
129
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1800
Peptide:
GSTDYGILQINSRWWC
Length:
16
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P19849
UniProt Name:
LYSC_PAVCR
Protein Name:
Lysozyme C
Position:
49-64
Literature
PMID:
10884350
Reference:
J Mol Biol. 2000 Jul 14;300(3):541-9.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
43.75
NuAPRpred:
0.73
Tango:
1.69
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.8
Area of the profile Above Threshold (AGGRESCAN):
2.81
Best Energy Score (PASTA 2.0):
-3.27
Aggregate Orientation (PASTA 2.0):
Parallel
