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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 661 to 690 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0661
MGMLAS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0662
MGNNTV
6
Non-amyloid
RNA-binding suppressor of PAS kinase protein 1
Q05672
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0663
MHVNIQ
6
Amyloid
Glutamate--cysteine ligase catalytic subunit
P48506
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-0664
MIENIQ
6
Amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0665
MIFFIY
6
Non-amyloid
Guanylate cyclase soluble subunit beta-2 (GCS-beta-2)
O75343
CPAD, WALTZ
P-0666
MIHFGN
6
Amyloid
Major prion protein (PrP)
P04925
No
Biochemistry. 2011 Apr 5;50(13):2456-63.
21323366
Waltz-DB 2.0, AmyLoad
P-0667
MINLYT
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0668
MLASQQ
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0669
MLASRQ
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
Q343R
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0670
MLVLFV
6
Amyloid
Major prion protein (PrP)
P04156
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0671
MMAAAQ
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0672
MMGMLA
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0673
MMHFGN
6
Amyloid
Major prion protein (PrP)
P04273
No
Biochemistry. 2011 Apr 5;50(13):2456-63.
21323366
Waltz-DB 2.0, AmyLoad
P-0674
MNFGAF
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0675
MNFGTF
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
A315T
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0676
MQIVYK
6
amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
V623M
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0677
MSDSNQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0678
MSLNDF
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0679
MTFIQN
6
Amyloid
Integrin alpha-8
P53708
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0680
MTVIIE
6
Amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0681
MTVKQF
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0682
MVGGVV
6
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Ann Gastroenterol Hepatol (Paris). 1991 Oct;27(5):215-8
1746874
CPAD, Waltz-DB 2.0, AmyLoad
P-0683
MYFFIF
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0684
MYWIIF
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0685
NAGSGS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0686
NANASS
6
Non-amyloid
Nuclear polyadenylated RNA-binding protein 4 (Cleavage factor IB) (CFIB)
Q99383
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0687
NANTSN
6
Non-amyloid
Nucleoporin NSP1
P14907
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0688
NAQAQP
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0689
NATAHQ
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0690
NATKKV
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0661 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0661
Peptide:
MGMLAS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
337-342
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.45
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
26.3
Area of the profile Above Threshold (AGGRESCAN):
1.81
Best Energy Score (PASTA 2.0):
0.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0662 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
A
L
D
S
R
N
W
G
L
T
P
A
M
E
T
G
L
F
Q
K
P
Q
D
R
I
F
I
I
E
L
E
N
S
I
V
S
F
I
N
S
N
T
E
S
F
Q
L
R
P
M
N
S
Y
Y
R
L
L
S
60
61
H
Q
I
A
E
Y
H
N
L
N
H
V
L
A
R
T
Q
D
S
C
V
I
L
F
K
G
E
N
F
Q
K
I
E
G
K
P
L
L
Q
E
L
Q
L
N
K
K
P
E
E
C
A
S
S
S
E
S
I
E
K
S
120
121
N
N
N
R
I
F
R
I
L
K
R
K
E
V
G
N
E
C
D
Y
K
I
D
G
N
T
R
T
P
N
S
N
L
T
A
N
S
N
K
D
Q
K
I
E
I
D
D
K
S
S
T
D
L
E
Q
E
R
I
E
K
180
181
E
R
L
Y
E
Q
R
K
Q
E
I
F
D
K
L
N
K
S
E
D
D
V
K
S
T
N
S
S
G
S
S
D
S
D
N
E
W
S
D
W
L
N
G
D
D
S
N
T
Q
T
S
N
G
S
V
S
S
S
S
P
240
241
F
N
S
S
V
T
T
I
Q
V
N
K
P
Q
Q
Q
F
Y
D
S
R
R
G
R
G
G
R
R
R
G
T
N
N
Y
K
D
A
Y
R
G
Q
S
R
R
N
K
E
N
G
G
Y
Q
S
G
Y
S
S
P
Y
L
300
301
V
Y
P
P
P
Q
M
G
G
N
S
L
P
T
Y
P
L
M
Y
N
P
A
G
P
A
P
G
P
A
P
S
P
M
V
M
G
N
N
T
V
F
M
N
P
Y
M
Y
N
M
N
P
Q
G
S
C
S
F
G
T
P
360
361
I
P
M
Y
P
P
Y
Q
Y
Q
Y
Q
Y
Q
Y
N
T
Q
Y
H
S
G
P
Y
S
N
T
P
S
Y
N
S
N
N
Y
T
R
S
S
A
N
K
Y
H
H
F
Q
G
K
N
S
Y
S
G
A
I
P
K
R
S
420
421
D
D
S
N
S
N
K
N
E
G
I
R
R
A
S
V
E
G
S
P
S
S
R
D
T
D
S
V
E
M
K
F
D
K
L
N
I
457
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0662
Peptide:
MGNNTV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q05672
UniProt Name:
RBS1_YEAST
Protein Name:
RNA-binding suppressor of PAS kinase protein 1
Position:
335-340
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.37
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-2.04
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0663 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0663
Peptide:
MHVNIQ
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P48506
UniProt Name:
GSH1_HUMAN
Protein Name:
Glutamate--cysteine ligase catalytic subunit
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-4.9
Area of the profile Above Threshold (AGGRESCAN):
0.42
Best Energy Score (PASTA 2.0):
-4.05
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0664 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0664
Peptide:
MIENIQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-27.0
Area of the profile Above Threshold (AGGRESCAN):
0.39
Best Energy Score (PASTA 2.0):
-1.48
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0665 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0665
Peptide:
MIFFIY
Length:
6
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
O75343
UniProt Name:
GCYB2_HUMAN
Protein Name:
Guanylate cyclase soluble subunit beta-2 (GCS-beta-2)
Position:
Literature
PMID:
Reference:
source:
CPAD, WALTZ
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.02
Tango:
244.86
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
121.4
Area of the profile Above Threshold (AGGRESCAN):
7.87
Best Energy Score (PASTA 2.0):
-6.34
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0666 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
Y
W
L
L
A
L
F
V
T
M
W
T
D
V
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
T
W
G
Q
P
H
60
61
G
G
G
W
G
Q
P
H
G
G
S
W
G
Q
P
H
G
G
S
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
N
Q
W
N
K
P
S
K
P
K
T
N
L
K
H
V
A
G
A
A
A
A
G
A
V
120
121
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
M
I
H
F
G
N
D
W
E
D
R
Y
Y
R
E
N
M
Y
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
S
N
Q
N
N
F
V
H
D
C
V
N
180
181
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
V
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
R
S
S
S
T
V
L
F
S
S
P
P
240
241
V
I
L
L
I
S
F
L
I
F
L
I
V
G
254
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0666
Peptide:
MIHFGN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
3NVG
Protein Information
UniProt ID:
P04925
UniProt Name:
PRIO_MOUSE
Protein Name:
Major prion protein (PrP)
Position:
137-142
Literature
PMID:
21323366
Reference:
Biochemistry. 2011 Apr 5;50(13):2456-63.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.11
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.6
Area of the profile Above Threshold (AGGRESCAN):
1.73
Best Energy Score (PASTA 2.0):
-2.96
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0667 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0667
Peptide:
MINLYT
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
321-326
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.46
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
30.8
Area of the profile Above Threshold (AGGRESCAN):
2.09
Best Energy Score (PASTA 2.0):
-3.4
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0668 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0668
Peptide:
MLASQQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
339-344
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-25.9
Area of the profile Above Threshold (AGGRESCAN):
0.38
Best Energy Score (PASTA 2.0):
0.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0669 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0669
Peptide:
MLASRQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
Q343R
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
339-344
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.0
Area of the profile Above Threshold (AGGRESCAN):
0.38
Best Energy Score (PASTA 2.0):
0.23
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0670 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0670
Peptide:
MLVLFV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
8-13
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.04
Tango:
210.06
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
108.2
Area of the profile Above Threshold (AGGRESCAN):
6.99
Best Energy Score (PASTA 2.0):
-6.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0671 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0671
Peptide:
MMAAAQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
322-327
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.1
Area of the profile Above Threshold (AGGRESCAN):
0.47
Best Energy Score (PASTA 2.0):
0.64
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0672 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0672
Peptide:
MMGMLA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
336-341
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
28.7
Area of the profile Above Threshold (AGGRESCAN):
1.91
Best Energy Score (PASTA 2.0):
-0.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0673 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
S
Y
W
L
L
A
L
F
V
A
M
W
T
D
V
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
T
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
N
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
M
M
H
F
G
N
D
W
E
D
R
Y
Y
R
E
N
M
N
R
Y
P
N
Q
V
Y
Y
R
P
V
D
Q
Y
N
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
I
K
I
M
E
R
V
V
E
Q
M
C
T
T
Q
Y
Q
K
E
S
Q
A
Y
Y
D
G
R
R
S
S
A
V
L
F
S
S
P
P
240
241
V
I
L
L
I
S
F
L
I
F
L
M
V
G
254
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0673
Peptide:
MMHFGN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
3NVE
Protein Information
UniProt ID:
P04273
UniProt Name:
PRIO_MESAU
Protein Name:
Major prion protein (PrP)
Position:
138-143
Literature
PMID:
21323366
Reference:
Biochemistry. 2011 Apr 5;50(13):2456-63.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.28
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.6
Area of the profile Above Threshold (AGGRESCAN):
0.93
Best Energy Score (PASTA 2.0):
-1.36
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0674 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0674
Peptide:
MNFGAF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
311-316
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.1
Area of the profile Above Threshold (AGGRESCAN):
1.31
Best Energy Score (PASTA 2.0):
-0.1
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0675 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0675
Peptide:
MNFGTF
Length:
6
Classification:
Non-amyloid
Mutation(s):
A315T
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
311-316
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.17
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.5
Area of the profile Above Threshold (AGGRESCAN):
1.21
Best Energy Score (PASTA 2.0):
-0.68
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0676 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
E
S
P
L
Q
T
P
T
E
D
G
S
E
E
P
G
60
61
S
E
T
S
D
A
K
S
T
P
T
A
E
D
V
T
A
P
L
V
D
E
G
A
P
G
K
Q
A
A
A
Q
P
H
T
E
I
P
E
G
T
T
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
A
G
120
121
H
V
T
Q
E
P
E
S
G
K
V
V
Q
E
G
F
L
R
E
P
G
P
P
G
L
S
H
Q
L
M
S
G
M
P
G
A
P
L
L
P
E
G
P
R
E
A
T
R
Q
P
S
G
T
G
P
E
D
T
E
G
180
181
G
R
H
A
P
E
L
L
K
H
Q
L
L
G
D
L
H
Q
E
G
P
P
L
K
G
A
G
G
K
E
R
P
G
S
K
E
E
V
D
E
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
K
A
S
P
A
240
241
Q
D
G
R
P
P
Q
T
A
A
R
E
A
T
S
I
P
G
F
P
A
E
G
A
I
P
L
P
V
D
F
L
S
K
V
S
T
E
I
P
A
S
E
P
D
G
P
S
V
G
R
A
K
G
Q
D
A
P
L
E
300
301
F
T
F
H
V
E
I
T
P
N
V
Q
K
E
Q
A
H
S
E
E
H
L
G
R
A
A
F
P
G
A
P
G
E
G
P
E
A
R
G
P
S
L
G
E
D
T
K
E
A
D
L
P
E
P
S
E
K
Q
P
A
360
361
A
A
P
R
G
K
P
V
S
R
V
P
Q
L
K
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
T
S
T
R
S
S
A
K
T
L
K
N
R
P
C
L
S
P
K
H
P
T
P
G
S
S
420
421
D
P
L
I
Q
P
S
S
P
A
V
C
P
E
P
P
S
S
P
K
Y
V
S
S
V
T
S
R
T
G
S
S
G
A
K
E
M
K
L
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
480
481
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
540
541
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
I
N
K
K
L
D
600
601
L
S
N
V
Q
S
K
C
G
S
K
D
N
I
K
H
V
P
G
G
G
S
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
660
661
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
720
721
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
758
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0676
Peptide:
MQIVYK
Length:
6
Classification:
amyloid
Mutation(s):
V623M
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
623-628
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.24
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
49.1
Area of the profile Above Threshold (AGGRESCAN):
3.22
Best Energy Score (PASTA 2.0):
-3.16
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0677 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0677
Peptide:
MSDSNQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
1-6
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-85.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.03
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0678 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0678
Peptide:
MSLNDF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
124-129
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-18.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.25
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0679 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
P
G
A
S
R
G
P
R
G
S
Q
A
P
L
I
A
P
L
C
C
A
A
A
A
L
G
M
L
L
W
S
P
A
C
Q
A
F
N
L
D
V
E
K
L
T
V
Y
S
G
P
K
G
S
Y
F
G
Y
A
60
61
V
D
F
H
I
P
D
A
R
T
A
S
V
L
V
G
A
P
K
A
N
T
S
Q
P
D
I
V
E
G
G
A
V
Y
Y
C
P
W
P
A
E
G
S
A
Q
C
R
Q
I
P
F
D
T
T
N
N
R
K
I
R
120
121
V
N
G
T
K
E
P
I
E
F
K
S
N
Q
W
F
G
A
T
V
K
A
H
K
G
K
V
V
A
C
A
P
L
Y
H
W
R
T
L
K
P
T
P
E
K
D
P
V
G
T
C
Y
V
A
I
Q
N
F
S
A
180
181
Y
A
E
F
S
P
C
R
N
S
N
A
D
P
E
G
Q
G
Y
C
Q
A
G
F
S
L
D
F
Y
K
N
G
D
L
I
V
G
G
P
G
S
F
Y
W
Q
G
Q
V
I
T
A
S
V
A
D
I
I
A
N
Y
240
241
S
F
K
D
I
L
R
K
L
A
G
E
K
Q
T
E
V
A
P
A
S
Y
D
D
S
Y
L
G
Y
S
V
A
A
G
E
F
T
G
D
S
Q
Q
E
L
V
A
G
I
P
R
G
A
Q
N
F
G
Y
V
S
I
300
301
I
N
S
T
D
M
T
F
I
Q
N
F
T
G
E
Q
M
A
S
Y
F
G
Y
T
V
V
V
S
D
V
N
S
D
G
L
D
D
V
L
V
G
A
P
L
F
M
E
R
E
F
E
S
N
P
R
E
V
G
Q
I
360
361
Y
L
Y
L
Q
V
S
S
L
L
F
R
D
P
Q
I
L
T
G
T
E
T
F
G
R
F
G
S
A
M
A
H
L
G
D
L
N
Q
D
G
Y
N
D
I
A
I
G
V
P
F
A
G
K
D
Q
R
G
K
V
L
420
421
I
Y
N
G
N
K
D
G
L
N
T
K
P
S
Q
V
L
Q
G
V
W
A
S
H
A
V
P
S
G
F
G
F
T
L
R
G
D
S
D
I
D
K
N
D
Y
P
D
L
I
V
G
A
F
G
T
G
K
V
A
V
480
481
Y
R
A
R
P
V
V
T
V
D
A
Q
L
L
L
H
P
M
I
I
N
L
E
N
K
T
C
Q
V
P
D
S
M
T
S
A
A
C
F
S
L
R
V
C
A
S
V
T
G
Q
S
I
A
N
T
I
V
L
M
A
540
541
E
V
Q
L
D
S
L
K
Q
K
G
A
I
K
R
T
L
F
L
D
N
H
Q
A
H
R
V
F
P
L
V
I
K
R
Q
K
S
H
Q
C
Q
D
F
I
V
Y
L
R
D
E
T
E
F
R
D
K
L
S
P
I
600
601
N
I
S
L
N
Y
S
L
D
E
S
T
F
K
E
G
L
E
V
K
P
I
L
N
Y
Y
R
E
N
I
V
S
E
Q
A
H
I
L
V
D
C
G
E
D
N
L
C
V
P
D
L
K
L
S
A
R
P
D
K
H
660
661
Q
V
I
I
G
D
E
N
H
L
M
L
I
I
N
A
R
N
E
G
E
G
A
Y
E
A
E
L
F
V
M
I
P
E
E
A
D
Y
V
G
I
E
R
N
N
K
G
F
R
P
L
S
C
E
Y
K
M
E
N
V
720
721
T
R
M
V
V
C
D
L
G
N
P
M
V
S
G
T
N
Y
S
L
G
L
R
F
A
V
P
R
L
E
K
T
N
M
S
I
N
F
D
L
Q
I
R
S
S
N
K
D
N
P
D
S
N
F
V
S
L
Q
I
N
780
781
I
T
A
V
A
Q
V
E
I
R
G
V
S
H
P
P
Q
I
V
L
P
I
H
N
W
E
P
E
E
E
P
H
K
E
E
E
V
G
P
L
V
E
H
I
Y
E
L
H
N
I
G
P
S
T
I
S
D
T
I
L
840
841
E
V
G
W
P
F
S
A
R
D
E
F
L
L
Y
I
F
H
I
Q
T
L
G
P
L
Q
C
Q
P
N
P
N
I
N
P
Q
D
I
K
P
A
A
S
P
E
D
T
P
E
L
S
A
F
L
R
N
S
T
I
P
900
901
H
L
V
R
K
R
D
V
H
V
V
E
F
H
R
Q
S
P
A
K
I
L
N
C
T
N
I
E
C
L
Q
I
S
C
A
V
G
R
L
E
G
G
E
S
A
V
L
K
V
R
S
R
L
W
A
H
T
F
L
Q
960
961
R
K
N
D
P
Y
A
L
A
S
L
V
S
F
E
V
K
K
M
P
Y
T
D
Q
P
A
K
L
P
E
G
S
I
V
I
K
T
S
V
I
W
A
T
P
N
V
S
F
S
I
P
L
W
V
I
I
L
A
I
L
1020
1021
L
G
L
L
V
L
A
I
L
T
L
A
L
W
K
C
G
F
F
D
R
A
R
P
P
Q
E
D
M
T
D
R
E
Q
L
T
N
D
K
T
P
E
A
1063
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0679
Peptide:
MTFIQN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P53708
UniProt Name:
ITA8_HUMAN
Protein Name:
Integrin alpha-8
Position:
306-311
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.06
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
31.0
Area of the profile Above Threshold (AGGRESCAN):
2.26
Best Energy Score (PASTA 2.0):
-3.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0680 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0680
Peptide:
MTVIIE
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
67.4
Area of the profile Above Threshold (AGGRESCAN):
4.43
Best Energy Score (PASTA 2.0):
-6.21
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0681 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0681
Peptide:
MTVKQF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
113-118
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.3
Area of the profile Above Threshold (AGGRESCAN):
0.36
Best Energy Score (PASTA 2.0):
-1.66
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0682 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0682
Peptide:
MVGGVV
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
2OKZ, 2ONA
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
706-711
Literature
PMID:
1746874
Reference:
Ann Gastroenterol Hepatol (Paris). 1991 Oct;27(5):215-8
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.71
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
28.1
Area of the profile Above Threshold (AGGRESCAN):
1.84
Best Energy Score (PASTA 2.0):
-3.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0683 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0683
Peptide:
MYFFIF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
0.94
Tango:
260.66
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
118.5
Area of the profile Above Threshold (AGGRESCAN):
7.63
Best Energy Score (PASTA 2.0):
-5.25
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0684 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0684
Peptide:
MYWIIF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
100.0
NuAPRpred:
1.01
Tango:
197.36
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
105.5
Area of the profile Above Threshold (AGGRESCAN):
6.79
Best Energy Score (PASTA 2.0):
-6.35
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0685 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0685
Peptide:
NAGSGS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
390-395
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-58.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0686 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
S
D
E
E
D
F
N
D
I
Y
G
D
D
K
P
T
T
T
E
E
V
K
K
E
E
E
Q
N
K
A
G
S
G
T
S
Q
L
D
Q
L
A
A
L
Q
A
L
S
S
S
L
N
K
L
N
N
P
N
S
60
61
N
N
S
S
S
N
N
S
N
Q
D
T
S
S
S
K
Q
D
G
T
A
N
D
K
E
G
S
N
E
D
T
K
N
E
K
K
Q
E
S
A
T
S
A
N
A
N
A
N
A
S
S
A
G
P
S
G
L
P
W
E
120
121
Q
L
Q
Q
T
M
S
Q
F
Q
Q
P
S
S
Q
S
P
P
Q
Q
Q
V
T
Q
T
K
E
E
R
S
K
A
D
L
S
K
E
S
C
K
M
F
I
G
G
L
N
W
D
T
T
E
D
N
L
R
E
Y
F
G
180
181
K
Y
G
T
V
T
D
L
K
I
M
K
D
P
A
T
G
R
S
R
G
F
G
F
L
S
F
E
K
P
S
S
V
D
E
V
V
K
T
Q
H
I
L
D
G
K
V
I
D
P
K
R
A
I
P
R
D
E
Q
D
240
241
K
T
G
K
I
F
V
G
G
I
G
P
D
V
R
P
K
E
F
E
E
F
F
S
Q
W
G
T
I
I
D
A
Q
L
M
L
D
K
D
T
G
Q
S
R
G
F
G
F
V
T
Y
D
S
A
D
A
V
D
R
V
300
301
C
Q
N
K
F
I
D
F
K
D
R
K
I
E
I
K
R
A
E
P
R
H
M
Q
Q
K
S
S
N
N
G
G
N
N
G
G
N
N
M
N
R
R
G
G
N
F
G
N
Q
G
D
F
N
Q
M
Y
Q
N
P
M
360
361
M
G
G
Y
N
P
M
M
N
P
Q
A
M
T
D
Y
Y
Q
K
M
Q
E
Y
Y
Q
Q
M
Q
K
Q
T
G
M
D
Y
T
Q
M
Y
Q
Q
Q
M
Q
Q
M
A
M
M
M
P
G
F
A
M
P
P
N
A
M
420
421
T
L
N
Q
P
Q
Q
D
S
N
A
T
Q
G
S
P
A
P
S
D
S
D
N
N
K
S
N
D
V
Q
T
I
G
N
T
S
N
T
D
S
G
S
P
P
L
N
L
P
N
G
P
K
G
P
S
Q
Y
N
D
D
480
481
H
N
S
G
Y
G
Y
N
R
D
R
G
D
R
D
R
N
D
R
D
R
D
Y
N
H
R
S
G
G
N
H
R
R
N
G
R
G
G
R
G
G
Y
N
R
R
N
N
G
Y
H
P
Y
N
R
534
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0686
Peptide:
NANASS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q99383
UniProt Name:
HRP1_YEAST
Protein Name:
Nuclear polyadenylated RNA-binding protein 4 (Cleavage factor IB) (CFIB)
Position:
106-111
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.42
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-65.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.05
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0687 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
N
F
N
T
P
Q
Q
N
K
T
P
F
S
F
G
T
A
N
N
N
S
N
T
T
N
Q
N
S
S
T
G
A
G
A
F
G
T
G
Q
S
T
F
G
F
N
N
S
A
P
N
N
T
N
N
A
N
S
S
I
60
61
T
P
A
F
G
S
N
N
T
G
N
T
A
F
G
N
S
N
P
T
S
N
V
F
G
S
N
N
S
T
T
N
T
F
G
S
N
S
A
G
T
S
L
F
G
S
S
S
A
Q
Q
T
K
S
N
G
T
A
G
G
120
121
N
T
F
G
S
S
S
L
F
N
N
S
T
N
S
N
T
T
K
P
A
F
G
G
L
N
F
G
G
G
N
N
T
T
P
S
S
T
G
N
A
N
T
S
N
N
L
F
G
A
T
A
N
A
N
K
P
A
F
S
180
181
F
G
A
T
T
N
D
D
K
K
T
E
P
D
K
P
A
F
S
F
N
S
S
V
G
N
K
T
D
A
Q
A
P
T
T
G
F
S
F
G
S
Q
L
G
G
N
K
T
V
N
E
A
A
K
P
S
L
S
F
G
240
241
S
G
S
A
G
A
N
P
A
G
A
S
Q
P
E
P
T
T
N
E
P
A
K
P
A
L
S
F
G
T
A
T
S
D
N
K
T
T
N
T
T
P
S
F
S
F
G
A
K
S
D
E
N
K
A
G
A
T
S
K
300
301
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
360
361
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
P
D
E
N
K
A
S
A
T
S
K
P
A
F
S
F
G
A
K
P
E
E
K
K
D
D
N
S
S
K
P
A
F
S
F
G
420
421
A
K
S
N
E
D
K
Q
D
G
T
A
K
P
A
F
S
F
G
A
K
P
A
E
K
N
N
N
E
T
S
K
P
A
F
S
F
G
A
K
S
D
E
K
K
D
G
D
A
S
K
P
A
F
S
F
G
A
K
S
480
481
D
E
K
K
D
S
D
S
S
K
P
A
F
S
F
G
T
K
S
N
E
K
K
D
S
G
S
S
K
P
A
F
S
F
G
A
K
P
D
E
K
K
N
D
E
V
S
K
P
A
F
S
F
G
A
K
A
N
E
K
540
541
K
E
S
D
E
S
K
S
A
F
S
F
G
S
K
P
T
G
K
E
E
G
D
G
A
K
A
A
I
S
F
G
A
K
P
E
E
Q
K
S
S
D
T
S
K
P
A
F
T
F
G
A
Q
K
D
N
E
K
K
T
600
601
E
E
S
S
T
G
K
S
T
A
D
V
K
S
S
D
S
L
K
L
N
S
K
P
V
E
L
K
P
V
S
L
D
N
K
T
L
D
D
L
V
T
K
W
T
N
Q
L
T
E
S
A
S
H
F
E
Q
Y
T
K
660
661
K
I
N
S
W
D
Q
V
L
V
K
G
G
E
Q
I
S
Q
L
Y
S
D
A
V
M
A
E
H
S
Q
N
K
I
D
Q
S
L
Q
Y
I
E
R
Q
Q
D
E
L
E
N
F
L
D
N
F
E
T
K
T
E
A
720
721
L
L
S
D
V
V
S
T
S
S
G
A
A
A
N
N
N
D
Q
K
R
Q
Q
A
Y
K
T
A
Q
T
L
D
E
N
L
N
S
L
S
S
N
L
S
S
L
I
V
E
I
N
N
V
S
N
T
F
N
K
T
T
780
781
N
I
D
I
N
N
E
D
E
N
I
Q
L
I
K
I
L
N
S
H
F
D
A
L
R
S
L
D
D
N
S
T
S
L
E
K
Q
I
N
S
I
K
K
823
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0687
Peptide:
NANTSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14907
UniProt Name:
NSP1_YEAST
Protein Name:
Nucleoporin NSP1
Position:
160-165
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-77.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0688 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0688
Peptide:
NAQAQP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
36-41
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-76.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.96
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0689 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0689
Peptide:
NATAHQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
145-150
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-61.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.38
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0690 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0690
Peptide:
NATKKV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
156-161
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.21
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-49.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.36
Aggregate Orientation (PASTA 2.0):
Antiparallel
