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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 721 to 750 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0721
NIDQSF
6
Non-amyloid
Carboxylic ester hydrolase
D3DNN4
No
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0722
NIFNFT
6
Amyloid
No
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
14691246
Waltz-DB 2.0, AmyLoad
P-0723
NIFNIT
6
Amyloid
No
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
14691246
Waltz-DB 2.0, AmyLoad
P-0724
NIFWVQ
6
Amyloid
Tyrosine-protein kinase Mer
Q12866
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0725
NIGNNS
6
Non-amyloid
Nucleoporin ASM4 (Nuclear pore protein NUP59)
Q05166
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0726
NIGQSF
6
Non-amyloid
Carboxylic ester hydrolase
D3DNN4
D139G
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0727
NINFFT
6
Amyloid
No
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
14691246
Waltz-DB 2.0, AmyLoad
P-0728
NINFIT
6
Amyloid
No
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
14691246
Waltz-DB 2.0, AmyLoad
P-0729
NININV
6
Non-amyloid
SWI/SNF chromatin-remodeling complex subunit SWI1
P09547
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0730
NINKSN
6
Amyloid
Glucose repression mediator protein CYC8
P14922
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0731
NINNNN
6
Non-amyloid
Asparagine-rich protein (Protein ARP)
P32770
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0732
NINNSI
6
Non-amyloid
U6 snRNA-associated Sm-like protein LSm4
P40070
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0733
NINNST
6
Non-amyloid
SWI/SNF chromatin-remodeling complex subunit SWI1
P09547
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0734
NIQYQF
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0735
NISNNN
6
Non-amyloid
RNA-binding protein MRN1
Q08925
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0736
NIVLIM
6
Non-amyloid
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, Waltz-DB 2.0, AmyLoad
P-0737
NIYQYG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0738
NKFGGP
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0739
NKGAII
6
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
J Am Chem Soc. 2014 Dec 31;136(52):18044-51., Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
25474758
AmyLoad, Waltz-DB 2.0
P-0740
NKGAIK
6
Non-amyloid
Amyloid-beta precursor protein (APP)
P05067
I32K
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
25474758
AmyLoad
P-0741
NLFYQL
6
Amyloid
DNA mismatch repair protein Mlh3 (MutL protein homolog 3)
Q9UHC1
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0742
NLGPVL
6
Non-amyloid
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0743
NLQGYQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0744
NLYTDR
6
Non-amyloid
RNA-binding protein FUS
P35637
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0745
NMGGGM
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0746
NMNMNL
6
Non-amyloid
Nitrogen regulatory protein GLN3
P18494
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0747
NNATAH
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0748
NNGGNN
6
Non-amyloid
Nuclear polyadenylated RNA-binding protein 4 (Cleavage factor IB) (CFIB)
Q99383
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0749
NNLQGY
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0750
NNNGNQ
6
Non-amyloid
[PIN+] prion protein RNQ1
P25367
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
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Entry: P-0721 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
V
Q
S
N
L
Q
A
G
A
A
A
A
S
C
I
S
P
K
Y
Y
M
I
F
T
P
C
K
L
C
H
L
C
C
R
E
S
E
I
N
M
H
S
K
V
T
I
I
C
I
R
F
L
F
W
F
L
L
L
60
61
C
M
L
I
G
K
S
H
T
E
D
D
I
I
I
A
T
K
N
G
K
V
R
G
M
N
L
T
V
F
G
G
T
V
T
A
F
L
G
I
P
Y
A
Q
P
P
L
G
R
L
R
F
K
K
P
Q
S
L
T
K
120
121
W
S
D
I
W
N
A
T
K
Y
A
N
S
C
C
Q
N
I
D
Q
S
F
P
G
F
H
G
S
E
M
W
N
P
N
T
D
L
S
E
D
C
L
Y
L
N
V
W
I
P
A
P
K
P
K
N
A
T
V
L
I
180
181
W
I
Y
G
G
G
F
Q
T
G
T
S
S
L
H
V
Y
D
G
K
F
L
A
R
V
E
R
V
I
V
V
S
M
N
Y
R
V
G
A
L
G
F
L
A
L
P
G
N
P
E
A
P
G
N
M
G
L
F
D
Q
240
241
Q
L
A
L
Q
W
V
Q
K
N
I
A
A
F
G
G
N
P
K
S
V
T
L
F
G
E
S
A
G
A
A
S
V
S
L
H
L
L
S
P
G
S
H
S
L
F
T
R
A
I
L
Q
S
G
S
F
N
A
P
W
300
301
A
V
T
S
L
Y
E
A
R
N
R
T
L
N
L
A
K
L
T
G
C
S
R
E
N
E
T
E
I
I
K
C
L
R
N
K
D
P
Q
E
I
L
L
N
E
A
F
V
V
P
Y
G
T
P
L
S
V
N
F
G
360
361
P
T
V
D
G
D
F
L
T
D
M
P
D
I
L
L
E
L
G
Q
F
K
K
T
Q
I
L
V
G
V
N
K
D
E
G
T
A
F
L
V
Y
G
A
P
G
F
S
K
D
N
N
S
I
I
T
R
K
E
F
Q
420
421
E
G
L
K
I
F
F
P
G
V
S
E
F
G
K
E
S
I
L
F
H
Y
T
D
W
V
D
D
Q
R
P
E
N
Y
R
E
A
L
G
D
V
V
G
D
Y
N
F
I
C
P
A
L
E
F
T
K
K
F
S
E
480
481
W
G
N
N
A
F
F
Y
Y
F
E
H
R
S
S
K
L
P
W
P
E
W
M
G
V
M
H
G
Y
E
I
E
F
V
F
G
L
P
L
E
R
R
D
N
Y
T
K
A
E
E
I
L
S
R
S
I
V
K
R
W
540
541
A
N
F
A
K
Y
G
N
P
N
E
T
Q
N
N
S
T
S
W
P
V
F
K
S
T
E
Q
K
Y
L
T
L
N
T
E
S
T
R
I
M
T
K
L
R
A
Q
Q
C
R
F
W
T
S
F
F
P
K
V
L
E
600
601
M
T
G
N
I
D
E
A
E
W
E
W
K
A
G
F
H
R
W
N
N
Y
M
M
D
W
K
N
Q
F
N
D
Y
T
S
K
K
E
S
C
V
G
L
643
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0721
Peptide:
NIDQSF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
D3DNN4
UniProt Name:
D3DNN4_HUMAN
Protein Name:
Carboxylic ester hydrolase
Position:
137-142
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-54.5
Area of the profile Above Threshold (AGGRESCAN):
0.06
Best Energy Score (PASTA 2.0):
0.3
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0722 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0722
Peptide:
NIFNFT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
14691246
Reference:
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.0
Area of the profile Above Threshold (AGGRESCAN):
1.78
Best Energy Score (PASTA 2.0):
-3.81
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0723 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0723
Peptide:
NIFNIT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
14691246
Reference:
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
25.0
Area of the profile Above Threshold (AGGRESCAN):
1.84
Best Energy Score (PASTA 2.0):
-4.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0724 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
P
A
P
L
P
L
L
L
G
L
F
L
P
A
L
W
R
R
A
I
T
E
A
R
E
E
A
K
P
Y
P
L
F
P
G
P
F
P
G
S
L
Q
T
D
H
T
P
L
L
S
L
P
H
A
S
G
Y
Q
60
61
P
A
L
M
F
S
P
T
Q
P
G
R
P
H
T
G
N
V
A
I
P
Q
V
T
S
V
E
S
K
P
L
P
P
L
A
F
K
H
T
V
G
H
I
I
L
S
E
H
K
G
V
K
F
N
C
S
I
S
V
P
120
121
N
I
Y
Q
D
T
T
I
S
W
W
K
D
G
K
E
L
L
G
A
H
H
A
I
T
Q
F
Y
P
D
D
E
V
T
A
I
I
A
S
F
S
I
T
S
V
Q
R
S
D
N
G
S
Y
I
C
K
M
K
I
N
180
181
N
E
E
I
V
S
D
P
I
Y
I
E
V
Q
G
L
P
H
F
T
K
Q
P
E
S
M
N
V
T
R
N
T
A
F
N
L
T
C
Q
A
V
G
P
P
E
P
V
N
I
F
W
V
Q
N
S
S
R
V
N
E
240
241
Q
P
E
K
S
P
S
V
L
T
V
P
G
L
T
E
M
A
V
F
S
C
E
A
H
N
D
K
G
L
T
V
S
K
G
V
Q
I
N
I
K
A
I
P
S
P
P
T
E
V
S
I
R
N
S
T
A
H
S
I
300
301
L
I
S
W
V
P
G
F
D
G
Y
S
P
F
R
N
C
S
I
Q
V
K
E
A
D
P
L
S
N
G
S
V
M
I
F
N
T
S
A
L
P
H
L
Y
Q
I
K
Q
L
Q
A
L
A
N
Y
S
I
G
V
S
360
361
C
M
N
E
I
G
W
S
A
V
S
P
W
I
L
A
S
T
T
E
G
A
P
S
V
A
P
L
N
V
T
V
F
L
N
E
S
S
D
N
V
D
I
R
W
M
K
P
P
T
K
Q
Q
D
G
E
L
V
G
Y
420
421
R
I
S
H
V
W
Q
S
A
G
I
S
K
E
L
L
E
E
V
G
Q
N
G
S
R
A
R
I
S
V
Q
V
H
N
A
T
C
T
V
R
I
A
A
V
T
R
G
G
V
G
P
F
S
D
P
V
K
I
F
I
480
481
P
A
H
G
W
V
D
Y
A
P
S
S
T
P
A
P
G
N
A
D
P
V
L
I
I
F
G
C
F
C
G
F
I
L
I
G
L
I
L
Y
I
S
L
A
I
R
K
R
V
Q
E
T
K
F
G
N
A
F
T
E
540
541
E
D
S
E
L
V
V
N
Y
I
A
K
K
S
F
C
R
R
A
I
E
L
T
L
H
S
L
G
V
S
E
E
L
Q
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
600
601
V
M
E
G
N
L
K
Q
E
D
G
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
660
661
S
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
L
E
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
720
721
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
K
K
I
Y
S
G
D
Y
Y
R
Q
G
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
780
781
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
840
841
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
V
R
N
Q
A
D
V
I
Y
V
N
T
Q
L
L
E
S
S
E
G
L
A
Q
G
S
T
L
A
P
L
D
L
N
I
D
P
D
900
901
S
I
I
A
S
C
T
P
R
A
A
I
S
V
V
T
A
E
V
H
D
S
K
P
H
E
G
R
Y
I
L
N
G
G
S
E
E
W
E
D
L
T
S
A
P
S
A
A
V
T
A
E
K
N
S
V
L
P
G
E
960
961
R
L
V
R
N
G
V
S
W
S
H
S
S
M
L
P
L
G
S
S
L
P
D
E
L
L
F
A
D
D
S
S
E
G
S
E
V
L
M
999
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0724
Peptide:
NIFWVQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12866
UniProt Name:
MERTK_HUMAN
Protein Name:
Tyrosine-protein kinase Mer
Position:
228-233
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.94
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
58.0
Area of the profile Above Threshold (AGGRESCAN):
3.78
Best Energy Score (PASTA 2.0):
-5.77
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0725 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
F
G
I
R
S
G
N
N
N
G
G
F
T
N
L
T
S
Q
A
P
Q
T
T
Q
M
F
Q
S
Q
S
Q
L
Q
P
Q
P
Q
P
Q
P
Q
Q
Q
Q
Q
H
L
Q
F
N
G
S
S
D
A
S
S
L
R
60
61
F
G
N
S
L
S
N
T
V
N
A
N
N
Y
S
S
N
I
G
N
N
S
I
N
N
N
N
I
K
N
G
T
N
N
I
S
Q
H
G
Q
G
N
N
P
S
W
V
N
N
P
K
K
R
F
T
P
H
T
V
I
120
121
R
R
K
T
T
K
Q
N
S
S
S
D
I
N
Q
N
D
D
S
S
S
M
N
A
T
M
R
N
F
S
K
Q
N
Q
D
S
K
H
N
E
R
N
K
S
A
A
N
N
D
I
N
S
L
L
S
N
F
N
D
I
180
181
P
P
S
V
T
L
Q
D
W
Q
R
E
D
E
F
G
S
I
P
S
L
T
T
Q
F
V
T
D
K
Y
T
A
K
K
T
N
R
S
A
Y
D
S
K
N
T
P
N
V
F
D
K
D
S
Y
V
R
I
A
N
I
240
241
E
Q
N
H
L
D
N
N
Y
N
T
A
E
T
N
N
K
V
H
E
T
S
S
K
S
S
S
L
S
A
I
I
V
F
G
Y
P
E
S
I
S
N
E
L
I
E
H
F
S
H
F
G
H
I
M
E
D
F
Q
V
300
301
L
R
L
G
R
G
I
N
P
N
T
F
R
I
F
H
N
H
D
T
G
C
D
E
N
D
S
T
V
N
K
S
I
T
L
K
G
R
N
N
E
S
N
N
K
K
Y
P
I
F
T
G
E
S
W
V
K
L
T
Y
360
361
N
S
P
S
S
A
L
R
A
L
Q
E
N
G
T
I
F
R
G
S
L
I
G
C
I
P
Y
S
K
N
A
V
E
Q
L
A
G
C
K
I
D
N
V
D
D
I
G
E
F
N
V
S
M
Y
Q
N
S
S
T
S
420
421
S
T
S
N
T
P
S
P
P
N
V
I
I
T
D
G
T
L
L
R
E
D
D
N
T
P
A
G
H
A
G
N
P
T
N
I
S
S
P
I
V
A
N
S
P
N
K
R
L
D
V
I
D
G
K
L
P
F
M
Q
480
481
N
A
G
P
N
S
N
I
P
N
L
L
R
N
L
E
S
K
M
R
Q
Q
E
A
K
Y
R
N
N
E
P
A
G
F
T
H
K
L
S
N
W
L
F
G
W
N
D
L
528
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0725
Peptide:
NIGNNS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q05166
UniProt Name:
NUP59_YEAST
Protein Name:
Nucleoporin ASM4 (Nuclear pore protein NUP59)
Position:
77-82
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.33
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-63.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0726 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
V
Q
S
N
L
Q
A
G
A
A
A
A
S
C
I
S
P
K
Y
Y
M
I
F
T
P
C
K
L
C
H
L
C
C
R
E
S
E
I
N
M
H
S
K
V
T
I
I
C
I
R
F
L
F
W
F
L
L
L
60
61
C
M
L
I
G
K
S
H
T
E
D
D
I
I
I
A
T
K
N
G
K
V
R
G
M
N
L
T
V
F
G
G
T
V
T
A
F
L
G
I
P
Y
A
Q
P
P
L
G
R
L
R
F
K
K
P
Q
S
L
T
K
120
121
W
S
D
I
W
N
A
T
K
Y
A
N
S
C
C
Q
N
I
D
Q
S
F
P
G
F
H
G
S
E
M
W
N
P
N
T
D
L
S
E
D
C
L
Y
L
N
V
W
I
P
A
P
K
P
K
N
A
T
V
L
I
180
181
W
I
Y
G
G
G
F
Q
T
G
T
S
S
L
H
V
Y
D
G
K
F
L
A
R
V
E
R
V
I
V
V
S
M
N
Y
R
V
G
A
L
G
F
L
A
L
P
G
N
P
E
A
P
G
N
M
G
L
F
D
Q
240
241
Q
L
A
L
Q
W
V
Q
K
N
I
A
A
F
G
G
N
P
K
S
V
T
L
F
G
E
S
A
G
A
A
S
V
S
L
H
L
L
S
P
G
S
H
S
L
F
T
R
A
I
L
Q
S
G
S
F
N
A
P
W
300
301
A
V
T
S
L
Y
E
A
R
N
R
T
L
N
L
A
K
L
T
G
C
S
R
E
N
E
T
E
I
I
K
C
L
R
N
K
D
P
Q
E
I
L
L
N
E
A
F
V
V
P
Y
G
T
P
L
S
V
N
F
G
360
361
P
T
V
D
G
D
F
L
T
D
M
P
D
I
L
L
E
L
G
Q
F
K
K
T
Q
I
L
V
G
V
N
K
D
E
G
T
A
F
L
V
Y
G
A
P
G
F
S
K
D
N
N
S
I
I
T
R
K
E
F
Q
420
421
E
G
L
K
I
F
F
P
G
V
S
E
F
G
K
E
S
I
L
F
H
Y
T
D
W
V
D
D
Q
R
P
E
N
Y
R
E
A
L
G
D
V
V
G
D
Y
N
F
I
C
P
A
L
E
F
T
K
K
F
S
E
480
481
W
G
N
N
A
F
F
Y
Y
F
E
H
R
S
S
K
L
P
W
P
E
W
M
G
V
M
H
G
Y
E
I
E
F
V
F
G
L
P
L
E
R
R
D
N
Y
T
K
A
E
E
I
L
S
R
S
I
V
K
R
W
540
541
A
N
F
A
K
Y
G
N
P
N
E
T
Q
N
N
S
T
S
W
P
V
F
K
S
T
E
Q
K
Y
L
T
L
N
T
E
S
T
R
I
M
T
K
L
R
A
Q
Q
C
R
F
W
T
S
F
F
P
K
V
L
E
600
601
M
T
G
N
I
D
E
A
E
W
E
W
K
A
G
F
H
R
W
N
N
Y
M
M
D
W
K
N
Q
F
N
D
Y
T
S
K
K
E
S
C
V
G
L
643
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0726
Peptide:
NIGQSF
Length:
6
Classification:
Non-amyloid
Mutation(s):
D139G
Structure(s):
No structures
Protein Information
UniProt ID:
D3DNN4
UniProt Name:
D3DNN4_HUMAN
Protein Name:
Carboxylic ester hydrolase
Position:
137-142
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.09
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-28.5
Area of the profile Above Threshold (AGGRESCAN):
0.32
Best Energy Score (PASTA 2.0):
0.3
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0727 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0727
Peptide:
NINFFT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
14691246
Reference:
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.0
Area of the profile Above Threshold (AGGRESCAN):
1.78
Best Energy Score (PASTA 2.0):
-3.81
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0728 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0728
Peptide:
NINFIT
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
14691246
Reference:
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):87-92.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
25.0
Area of the profile Above Threshold (AGGRESCAN):
1.84
Best Energy Score (PASTA 2.0):
-4.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0729 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
F
F
N
L
N
N
N
N
N
N
N
N
T
T
T
T
T
T
T
T
N
N
N
N
T
N
N
N
N
T
N
N
N
N
N
P
A
N
N
T
N
N
N
N
S
T
G
H
S
S
N
T
N
N
N
T
N
N
60
61
N
N
T
N
T
G
A
S
G
V
D
D
F
Q
N
F
F
D
P
K
P
F
D
Q
N
L
D
S
N
N
N
N
S
N
S
N
N
N
D
N
N
N
S
N
T
V
A
S
S
T
N
F
T
S
P
T
A
V
V
N
120
121
N
A
A
P
A
N
V
T
G
G
K
A
A
N
F
I
Q
N
Q
S
P
Q
F
N
S
P
Y
D
S
N
N
S
N
T
N
L
N
S
L
S
P
Q
A
I
L
A
K
N
S
I
I
D
S
S
N
L
P
L
Q
A
180
181
Q
Q
Q
L
Y
G
G
N
N
N
N
N
S
T
G
I
A
N
D
N
V
I
T
P
H
F
I
T
N
V
Q
S
I
S
Q
N
S
S
S
S
T
P
N
T
N
S
N
S
T
P
N
A
N
Q
Q
F
L
P
F
N
240
241
N
S
A
S
N
N
G
N
L
T
S
N
Q
L
I
S
N
Y
A
A
S
N
S
M
D
R
S
S
S
A
S
N
E
F
V
P
N
T
S
D
N
N
N
N
S
N
N
H
N
M
R
N
N
S
N
N
K
T
S
N
300
301
N
N
N
V
T
A
V
P
A
A
T
P
A
N
T
N
N
S
T
S
N
A
N
T
V
F
S
E
R
A
A
M
F
A
A
L
Q
Q
K
Q
Q
Q
R
F
Q
A
L
Q
Q
Q
Q
Q
Q
Q
Q
N
Q
Q
Q
Q
360
361
N
Q
Q
P
Q
Q
Q
Q
Q
Q
Q
Q
N
P
K
F
L
Q
S
Q
R
Q
Q
Q
Q
R
S
I
L
Q
S
L
N
P
A
L
Q
E
K
I
S
T
E
L
N
N
K
Q
Y
E
L
F
M
K
S
L
I
E
N
C
420
421
K
K
R
N
M
P
L
Q
S
I
P
E
I
G
N
R
K
I
N
L
F
Y
L
Y
M
L
V
Q
K
F
G
G
A
D
Q
V
T
R
T
Q
Q
W
S
M
V
A
Q
R
L
Q
I
S
D
Y
Q
Q
L
E
S
I
480
481
Y
F
R
I
L
L
P
Y
E
R
H
M
I
S
Q
E
G
I
K
E
T
Q
A
K
R
I
F
L
Q
Q
F
L
Q
E
L
L
K
K
V
Q
Q
Q
Q
Q
A
A
A
L
A
N
A
N
N
N
I
N
S
A
S
S
540
541
A
P
T
P
A
A
P
G
A
S
V
P
A
T
A
A
P
G
T
E
A
G
I
V
P
V
S
A
N
T
P
K
S
L
N
S
N
I
N
I
N
V
N
N
N
N
I
G
Q
Q
Q
V
K
K
P
R
K
Q
R
V
600
601
K
K
K
T
K
K
E
L
E
L
E
R
K
E
R
E
D
F
Q
K
R
Q
Q
K
L
L
E
D
Q
Q
R
Q
Q
K
L
L
L
E
T
K
L
R
Q
Q
Y
E
I
E
L
K
K
L
P
K
V
Y
K
R
S
I
660
661
V
R
N
Y
K
P
L
I
N
R
L
K
H
Y
N
G
Y
D
I
N
Y
I
S
K
I
G
E
K
I
D
S
N
K
P
I
F
L
F
A
P
E
L
G
A
I
N
L
H
A
L
S
M
S
L
Q
S
K
N
L
G
720
721
E
I
N
T
A
L
N
T
L
L
V
T
S
A
D
S
N
L
K
I
S
L
V
K
Y
P
E
L
L
D
S
L
A
I
L
G
M
N
L
L
S
N
L
S
Q
N
V
V
P
Y
H
R
N
T
S
D
Y
Y
Y
E
780
781
D
A
G
S
N
Q
Y
Y
V
T
Q
H
D
K
M
V
D
K
I
F
E
K
V
N
N
N
A
T
L
T
P
N
D
S
N
D
E
K
V
T
I
L
V
D
S
L
T
G
N
Q
L
P
T
P
T
P
T
E
M
E
840
841
P
D
L
D
T
E
C
F
I
S
M
Q
S
T
S
P
A
V
K
Q
W
D
L
L
P
E
P
I
R
F
L
P
N
Q
F
P
L
K
I
H
R
T
P
Y
L
T
S
L
K
K
I
K
D
E
I
D
D
P
F
T
900
901
K
I
N
T
R
G
A
E
D
P
K
V
L
I
N
D
Q
L
S
T
I
S
M
I
L
R
N
I
S
F
S
D
N
N
S
R
I
M
S
R
N
F
Y
L
K
R
F
I
S
D
L
L
W
L
V
L
I
H
P
E
960
961
N
F
T
C
N
R
K
I
L
N
F
K
K
D
L
V
I
V
L
S
N
I
S
H
L
L
E
I
A
S
S
I
D
C
L
L
I
L
I
L
V
I
S
F
G
Q
P
K
L
N
P
M
A
S
S
S
S
F
G
S
1020
1021
E
S
L
T
F
N
E
F
Q
L
Q
W
G
K
Y
Q
T
F
G
V
D
I
L
A
K
L
F
S
L
E
K
P
N
L
N
Y
F
K
S
I
L
L
N
K
N
T
G
N
N
L
Y
D
R
N
S
N
N
N
H
K
1080
1081
D
K
K
L
L
R
R
L
L
N
L
Y
N
D
N
N
K
N
N
N
N
R
H
N
L
L
N
D
V
V
S
F
L
F
S
A
I
P
L
Q
Q
V
L
S
Q
S
A
D
P
S
L
L
I
D
Q
F
S
P
V
I
1140
1141
S
Q
S
L
T
S
I
L
V
I
V
Q
K
I
L
P
L
S
N
E
V
F
E
I
S
E
N
N
S
D
S
N
S
N
N
N
G
N
K
D
S
S
F
N
F
N
K
N
L
P
F
V
W
L
S
S
E
E
N
I
1200
1201
G
S
G
L
L
K
L
S
E
I
I
L
N
I
N
N
S
T
S
K
N
T
L
L
Q
Q
Q
N
Y
S
K
V
L
L
P
S
I
N
I
S
C
V
Q
L
I
K
C
L
V
E
K
S
I
C
F
E
N
C
L
N
1260
1261
N
D
P
E
I
L
K
K
I
A
S
I
P
N
L
F
P
T
D
L
E
I
F
Q
L
F
T
N
P
S
V
D
I
Q
I
I
N
Q
Y
Q
L
L
Y
N
L
K
N
D
I
L
T
N
L
E
1314
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0729
Peptide:
NININV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09547
UniProt Name:
SWI1_YEAST
Protein Name:
SWI/SNF chromatin-remodeling complex subunit SWI1
Position:
577-582
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.93
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.2
Area of the profile Above Threshold (AGGRESCAN):
0.55
Best Energy Score (PASTA 2.0):
-5.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0730 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
N
P
G
G
E
Q
T
I
M
E
Q
P
A
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
A
A
V
P
Q
Q
P
L
D
P
L
T
Q
S
T
A
E
T
W
L
S
I
A
S
L
A
E
T
L
G
60
61
D
G
D
R
A
A
M
A
Y
D
A
T
L
Q
F
N
P
S
S
A
K
A
L
T
S
L
A
H
L
Y
R
S
R
D
M
F
Q
R
A
A
E
L
Y
E
R
A
L
L
V
N
P
E
L
S
D
V
W
A
T
L
120
121
G
H
C
Y
L
M
L
D
D
L
Q
R
A
Y
N
A
Y
Q
Q
A
L
Y
H
L
S
N
P
N
V
P
K
L
W
H
G
I
G
I
L
Y
D
R
Y
G
S
L
D
Y
A
E
E
A
F
A
K
V
L
E
L
D
180
181
P
H
F
E
K
A
N
E
I
Y
F
R
L
G
I
I
Y
K
H
Q
G
K
W
S
Q
A
L
E
C
F
R
Y
I
L
P
Q
P
P
A
P
L
Q
E
W
D
I
W
F
Q
L
G
S
V
L
E
S
M
G
E
W
240
241
Q
G
A
K
E
A
Y
E
H
V
L
A
Q
N
Q
H
H
A
K
V
L
Q
Q
L
G
C
L
Y
G
M
S
N
V
Q
F
Y
D
P
Q
K
A
L
D
Y
L
L
K
S
L
E
A
D
P
S
D
A
T
T
W
Y
300
301
H
L
G
R
V
H
M
I
R
T
D
Y
T
A
A
Y
D
A
F
Q
Q
A
V
N
R
D
S
R
N
P
I
F
W
C
S
I
G
V
L
Y
Y
Q
I
S
Q
Y
R
D
A
L
D
A
Y
T
R
A
I
R
L
N
360
361
P
Y
I
S
E
V
W
Y
D
L
G
T
L
Y
E
T
C
N
N
Q
L
S
D
A
L
D
A
Y
K
Q
A
A
R
L
D
V
N
N
V
H
I
R
E
R
L
E
A
L
T
K
Q
L
E
N
P
G
N
I
N
K
420
421
S
N
G
A
P
T
N
A
S
P
A
P
P
P
V
I
L
Q
P
T
L
Q
P
N
D
Q
G
N
P
L
N
T
R
I
S
A
Q
S
A
N
A
T
A
S
M
V
Q
Q
Q
H
P
A
Q
Q
T
P
I
N
S
S
480
481
A
T
M
Y
S
N
G
A
S
P
Q
L
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
H
A
Q
A
540
541
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
A
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
L
Q
P
L
P
R
Q
Q
L
Q
Q
K
G
600
601
V
S
V
Q
M
L
N
P
Q
Q
G
Q
P
Y
I
T
Q
P
T
V
I
Q
A
H
Q
L
Q
P
F
S
T
Q
A
M
E
H
P
Q
S
S
Q
L
P
P
Q
Q
Q
Q
L
Q
S
V
Q
H
P
Q
Q
L
Q
G
660
661
Q
P
Q
A
Q
A
P
Q
P
L
I
Q
H
N
V
E
Q
N
V
L
P
Q
K
R
Y
M
E
G
A
I
H
T
L
V
D
A
A
V
S
S
S
T
H
T
E
N
N
T
K
S
P
R
Q
P
T
H
A
I
P
T
720
721
Q
A
P
A
T
G
I
T
N
A
E
P
Q
V
K
K
Q
K
L
N
S
P
N
S
N
I
N
K
L
V
N
T
A
T
S
I
E
E
N
A
K
S
E
V
S
N
Q
S
P
A
V
V
E
S
N
T
N
N
T
S
780
781
Q
E
E
K
P
V
K
A
N
S
I
P
S
V
I
G
A
Q
E
P
P
Q
E
A
S
P
A
E
E
A
T
K
A
A
S
V
S
P
S
T
K
P
L
N
T
E
P
E
S
S
S
V
Q
P
T
V
S
S
E
S
840
841
S
T
T
K
A
N
D
Q
S
T
A
E
T
I
E
L
S
T
A
T
V
P
A
E
A
S
P
V
E
D
E
V
R
Q
H
S
K
E
E
N
G
T
T
E
A
S
A
P
S
T
E
E
A
E
P
A
A
S
R
D
900
901
A
E
K
Q
Q
D
E
T
A
A
T
T
I
T
V
I
K
P
T
L
E
T
M
E
T
V
K
E
E
A
K
M
R
E
E
E
Q
T
S
Q
E
K
S
P
Q
E
N
T
L
P
R
E
N
V
V
R
Q
V
E
E
960
961
D
E
N
Y
D
D
966
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0730
Peptide:
NINKSN
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14922
UniProt Name:
CYC8_YEAST
Protein Name:
Glucose repression mediator protein CYC8
Position:
417-422
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.35
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-68.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0731 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
H
Y
V
V
L
E
L
Q
V
A
H
L
P
D
T
P
K
D
Q
C
R
I
A
N
I
A
F
Q
I
V
N
A
E
T
L
V
C
H
Y
G
T
N
S
L
P
S
I
E
V
N
G
T
T
K
S
L
E
S
A
60
61
M
V
Q
L
D
K
D
I
H
D
V
I
G
N
D
D
F
V
L
V
S
L
Y
S
T
W
H
I
R
V
T
L
P
R
Q
A
R
D
D
G
F
I
L
T
S
Y
L
Q
H
P
K
V
F
D
L
W
K
E
F
D
120
121
R
W
C
V
N
H
P
E
I
L
G
Q
K
K
A
I
S
N
N
N
C
N
T
K
S
I
S
I
N
A
A
K
N
T
K
D
L
D
E
I
V
R
I
L
E
V
S
I
P
T
E
E
A
G
S
V
P
E
I
Y
180
181
S
L
L
K
R
T
T
D
I
L
I
Q
L
H
K
K
C
T
S
P
E
D
M
E
S
V
L
T
K
P
Y
D
S
H
T
D
I
R
A
F
L
Q
E
K
S
K
I
L
Y
M
N
N
L
P
P
D
T
T
Q
S
240
241
E
L
E
S
W
F
T
Q
Y
G
V
R
P
V
G
F
W
T
V
K
N
I
V
E
D
T
S
N
V
N
N
N
W
S
L
N
N
S
P
Y
V
E
D
Q
D
S
I
S
G
F
V
V
F
Q
T
H
E
E
A
T
300
301
E
V
L
A
L
N
G
R
S
I
L
S
N
L
A
N
T
K
Q
P
R
V
V
E
H
V
L
E
L
Q
P
S
S
T
G
V
L
D
K
A
Q
E
I
L
S
P
F
P
Q
S
K
N
K
P
R
P
G
D
W
N
360
361
C
P
S
C
G
F
S
N
F
Q
R
R
T
A
C
F
R
C
S
F
P
A
P
S
N
S
Q
I
H
T
A
N
S
N
N
N
V
N
S
S
R
N
N
L
N
N
R
V
N
S
G
S
S
S
N
I
S
N
T
A
420
421
A
N
H
P
Y
G
A
P
E
F
N
M
I
A
N
N
T
P
A
A
L
T
Y
N
R
A
H
F
P
A
I
T
P
L
S
R
Q
N
S
L
N
M
A
P
S
N
S
G
S
P
I
I
I
A
D
H
F
S
G
N
480
481
N
N
I
A
P
N
Y
R
Y
N
N
N
I
N
N
N
N
N
N
I
N
N
M
T
N
N
R
Y
N
I
N
N
N
I
N
G
N
G
N
G
N
G
N
N
S
N
N
N
N
N
H
N
N
N
H
N
N
N
H
H
540
541
N
G
S
I
N
S
N
S
N
T
N
N
N
N
N
N
N
N
G
N
N
S
N
N
C
N
S
N
I
G
M
G
G
C
G
S
N
M
P
F
R
A
G
D
W
K
C
S
T
C
T
Y
H
N
F
A
K
N
V
V
600
601
C
L
R
C
G
G
P
K
S
I
S
G
D
A
S
E
T
N
H
Y
I
D
S
S
T
F
G
P
A
S
R
T
P
S
N
N
N
I
S
V
N
T
N
G
G
S
N
A
G
R
T
D
G
N
D
N
K
G
R
D
660
661
I
S
L
M
E
F
M
S
P
P
L
S
M
A
T
K
S
M
K
E
G
D
G
N
G
S
S
F
N
E
F
K
S
D
K
A
N
V
N
F
S
N
V
G
D
N
S
A
F
G
N
G
F
N
S
S
I
R
W
719
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0731
Peptide:
NINNNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32770
UniProt Name:
NRP1_YEAST
Protein Name:
Asparagine-rich protein (Protein ARP)
Position:
492-497
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
0.0
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-89.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0732 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
L
Y
L
L
T
N
A
K
G
Q
Q
M
Q
I
E
L
K
N
G
E
I
I
Q
G
I
L
T
N
V
D
N
W
M
N
L
T
L
S
N
V
T
E
Y
S
E
E
S
A
I
N
S
E
D
N
A
E
S
60
61
S
K
A
V
K
L
N
E
I
Y
I
R
G
T
F
I
K
F
I
K
L
Q
D
N
I
I
D
K
V
K
Q
Q
I
N
S
N
N
N
S
N
S
N
G
P
G
H
K
R
Y
Y
N
N
R
D
S
N
N
N
R
G
120
121
N
Y
N
R
R
N
N
N
N
G
N
S
N
R
R
P
Y
S
Q
N
R
Q
Y
N
N
S
N
S
S
N
I
N
N
S
I
N
S
I
N
S
N
N
Q
N
M
N
N
G
L
G
G
S
V
Q
H
H
F
N
S
S
180
181
S
P
Q
K
V
E
F
187
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0732
Peptide:
NINNSI
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P40070
UniProt Name:
LSM4_YEAST
Protein Name:
U6 snRNA-associated Sm-like protein LSm4
Position:
150-155
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-44.6
Area of the profile Above Threshold (AGGRESCAN):
0.17
Best Energy Score (PASTA 2.0):
-3.24
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0733 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
F
F
N
L
N
N
N
N
N
N
N
N
T
T
T
T
T
T
T
T
N
N
N
N
T
N
N
N
N
T
N
N
N
N
N
P
A
N
N
T
N
N
N
N
S
T
G
H
S
S
N
T
N
N
N
T
N
N
60
61
N
N
T
N
T
G
A
S
G
V
D
D
F
Q
N
F
F
D
P
K
P
F
D
Q
N
L
D
S
N
N
N
N
S
N
S
N
N
N
D
N
N
N
S
N
T
V
A
S
S
T
N
F
T
S
P
T
A
V
V
N
120
121
N
A
A
P
A
N
V
T
G
G
K
A
A
N
F
I
Q
N
Q
S
P
Q
F
N
S
P
Y
D
S
N
N
S
N
T
N
L
N
S
L
S
P
Q
A
I
L
A
K
N
S
I
I
D
S
S
N
L
P
L
Q
A
180
181
Q
Q
Q
L
Y
G
G
N
N
N
N
N
S
T
G
I
A
N
D
N
V
I
T
P
H
F
I
T
N
V
Q
S
I
S
Q
N
S
S
S
S
T
P
N
T
N
S
N
S
T
P
N
A
N
Q
Q
F
L
P
F
N
240
241
N
S
A
S
N
N
G
N
L
T
S
N
Q
L
I
S
N
Y
A
A
S
N
S
M
D
R
S
S
S
A
S
N
E
F
V
P
N
T
S
D
N
N
N
N
S
N
N
H
N
M
R
N
N
S
N
N
K
T
S
N
300
301
N
N
N
V
T
A
V
P
A
A
T
P
A
N
T
N
N
S
T
S
N
A
N
T
V
F
S
E
R
A
A
M
F
A
A
L
Q
Q
K
Q
Q
Q
R
F
Q
A
L
Q
Q
Q
Q
Q
Q
Q
Q
N
Q
Q
Q
Q
360
361
N
Q
Q
P
Q
Q
Q
Q
Q
Q
Q
Q
N
P
K
F
L
Q
S
Q
R
Q
Q
Q
Q
R
S
I
L
Q
S
L
N
P
A
L
Q
E
K
I
S
T
E
L
N
N
K
Q
Y
E
L
F
M
K
S
L
I
E
N
C
420
421
K
K
R
N
M
P
L
Q
S
I
P
E
I
G
N
R
K
I
N
L
F
Y
L
Y
M
L
V
Q
K
F
G
G
A
D
Q
V
T
R
T
Q
Q
W
S
M
V
A
Q
R
L
Q
I
S
D
Y
Q
Q
L
E
S
I
480
481
Y
F
R
I
L
L
P
Y
E
R
H
M
I
S
Q
E
G
I
K
E
T
Q
A
K
R
I
F
L
Q
Q
F
L
Q
E
L
L
K
K
V
Q
Q
Q
Q
Q
A
A
A
L
A
N
A
N
N
N
I
N
S
A
S
S
540
541
A
P
T
P
A
A
P
G
A
S
V
P
A
T
A
A
P
G
T
E
A
G
I
V
P
V
S
A
N
T
P
K
S
L
N
S
N
I
N
I
N
V
N
N
N
N
I
G
Q
Q
Q
V
K
K
P
R
K
Q
R
V
600
601
K
K
K
T
K
K
E
L
E
L
E
R
K
E
R
E
D
F
Q
K
R
Q
Q
K
L
L
E
D
Q
Q
R
Q
Q
K
L
L
L
E
T
K
L
R
Q
Q
Y
E
I
E
L
K
K
L
P
K
V
Y
K
R
S
I
660
661
V
R
N
Y
K
P
L
I
N
R
L
K
H
Y
N
G
Y
D
I
N
Y
I
S
K
I
G
E
K
I
D
S
N
K
P
I
F
L
F
A
P
E
L
G
A
I
N
L
H
A
L
S
M
S
L
Q
S
K
N
L
G
720
721
E
I
N
T
A
L
N
T
L
L
V
T
S
A
D
S
N
L
K
I
S
L
V
K
Y
P
E
L
L
D
S
L
A
I
L
G
M
N
L
L
S
N
L
S
Q
N
V
V
P
Y
H
R
N
T
S
D
Y
Y
Y
E
780
781
D
A
G
S
N
Q
Y
Y
V
T
Q
H
D
K
M
V
D
K
I
F
E
K
V
N
N
N
A
T
L
T
P
N
D
S
N
D
E
K
V
T
I
L
V
D
S
L
T
G
N
Q
L
P
T
P
T
P
T
E
M
E
840
841
P
D
L
D
T
E
C
F
I
S
M
Q
S
T
S
P
A
V
K
Q
W
D
L
L
P
E
P
I
R
F
L
P
N
Q
F
P
L
K
I
H
R
T
P
Y
L
T
S
L
K
K
I
K
D
E
I
D
D
P
F
T
900
901
K
I
N
T
R
G
A
E
D
P
K
V
L
I
N
D
Q
L
S
T
I
S
M
I
L
R
N
I
S
F
S
D
N
N
S
R
I
M
S
R
N
F
Y
L
K
R
F
I
S
D
L
L
W
L
V
L
I
H
P
E
960
961
N
F
T
C
N
R
K
I
L
N
F
K
K
D
L
V
I
V
L
S
N
I
S
H
L
L
E
I
A
S
S
I
D
C
L
L
I
L
I
L
V
I
S
F
G
Q
P
K
L
N
P
M
A
S
S
S
S
F
G
S
1020
1021
E
S
L
T
F
N
E
F
Q
L
Q
W
G
K
Y
Q
T
F
G
V
D
I
L
A
K
L
F
S
L
E
K
P
N
L
N
Y
F
K
S
I
L
L
N
K
N
T
G
N
N
L
Y
D
R
N
S
N
N
N
H
K
1080
1081
D
K
K
L
L
R
R
L
L
N
L
Y
N
D
N
N
K
N
N
N
N
R
H
N
L
L
N
D
V
V
S
F
L
F
S
A
I
P
L
Q
Q
V
L
S
Q
S
A
D
P
S
L
L
I
D
Q
F
S
P
V
I
1140
1141
S
Q
S
L
T
S
I
L
V
I
V
Q
K
I
L
P
L
S
N
E
V
F
E
I
S
E
N
N
S
D
S
N
S
N
N
N
G
N
K
D
S
S
F
N
F
N
K
N
L
P
F
V
W
L
S
S
E
E
N
I
1200
1201
G
S
G
L
L
K
L
S
E
I
I
L
N
I
N
N
S
T
S
K
N
T
L
L
Q
Q
Q
N
Y
S
K
V
L
L
P
S
I
N
I
S
C
V
Q
L
I
K
C
L
V
E
K
S
I
C
F
E
N
C
L
N
1260
1261
N
D
P
E
I
L
K
K
I
A
S
I
P
N
L
F
P
T
D
L
E
I
F
Q
L
F
T
N
P
S
V
D
I
Q
I
I
N
Q
Y
Q
L
L
Y
N
L
K
N
D
I
L
T
N
L
E
1314
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0733
Peptide:
NINNST
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09547
UniProt Name:
SWI1_YEAST
Protein Name:
SWI/SNF chromatin-remodeling complex subunit SWI1
Position:
1213-1218
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-64.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.91
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0734 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0734
Peptide:
NIQYQF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.59
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-7.1
Area of the profile Above Threshold (AGGRESCAN):
0.48
Best Energy Score (PASTA 2.0):
-1.94
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0735 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
V
V
S
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
I
S
N
N
N
N
N
N
N
M
F
P
P
F
P
S
S
D
D
F
A
M
Y
Q
Q
S
S
S
S
G
P
Y
Q
E
T
Y
A
S
G
P
Q
60
61
N
F
G
D
A
V
Y
P
M
N
G
N
F
T
L
L
P
S
D
F
T
R
E
P
N
D
S
F
F
Y
E
N
D
G
I
F
D
Y
Q
R
I
Q
Q
Q
P
T
Q
F
Q
T
K
Q
R
N
D
S
Q
Q
Q
R
120
121
F
S
Q
E
Q
N
F
E
I
D
N
E
V
V
H
N
N
N
R
Y
Y
E
Y
E
R
S
S
N
E
V
S
P
F
D
D
E
N
P
N
V
L
S
D
G
M
S
P
T
I
M
A
T
A
T
A
V
T
N
A
N
180
181
A
P
L
P
V
N
A
Q
A
N
N
P
L
N
F
T
S
A
P
S
R
T
V
Y
L
G
N
V
P
P
N
L
S
V
K
E
L
L
D
H
V
R
S
G
V
V
E
D
V
K
I
I
P
E
K
M
C
A
F
V
240
241
S
F
I
D
E
S
A
A
L
L
F
H
S
D
A
I
L
K
R
L
N
I
G
D
R
D
I
K
I
G
W
G
K
P
T
R
I
D
P
I
V
A
A
R
I
S
T
D
G
A
T
R
N
V
Y
I
G
R
M
T
300
301
I
E
G
E
E
S
H
L
S
E
E
Q
L
R
V
D
L
E
E
Y
G
E
I
D
C
I
K
I
I
K
E
K
G
I
A
F
I
H
F
A
S
I
L
N
A
I
K
V
V
T
N
L
P
I
R
N
P
Y
Y
Q
360
361
N
K
R
I
F
Y
G
K
D
R
C
A
F
I
T
K
T
Q
Q
H
N
A
A
Q
F
L
G
V
Q
P
G
M
E
H
M
I
E
F
S
D
R
E
F
I
S
N
A
L
L
Q
Q
S
A
A
A
A
A
I
A
T
420
421
S
A
G
G
P
N
N
L
G
N
R
T
V
Y
L
G
S
L
P
K
D
V
K
I
E
E
I
C
N
A
V
R
G
G
L
L
Q
S
I
K
L
L
N
D
R
Y
V
C
F
V
T
F
I
D
P
T
A
A
A
Q
480
481
F
Y
A
M
S
S
L
Y
G
F
T
V
Q
K
K
R
C
K
V
G
W
G
K
H
S
G
P
L
P
N
A
L
A
L
A
V
S
N
G
A
S
R
N
V
Y
V
G
N
I
D
F
V
G
D
S
L
R
D
E
R
540
541
V
F
T
E
S
N
L
R
H
I
F
Q
Q
Y
G
E
V
E
Q
I
N
F
L
P
E
K
N
C
C
F
I
N
Y
T
N
I
S
N
A
I
L
A
L
D
K
I
K
S
N
P
Y
F
K
D
L
K
I
N
F
G
600
601
K
D
R
C
G
N
V
P
H
Q
S
R
612
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0735
Peptide:
NISNNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q08925
UniProt Name:
MRN1_YEAST
Protein Name:
RNA-binding protein MRN1
Position:
19-24
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-69.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.26
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0736 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0736
Peptide:
NIVLIM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
1.05
Tango:
1.89
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
86.1
Area of the profile Above Threshold (AGGRESCAN):
5.48
Best Energy Score (PASTA 2.0):
-6.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0737 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0737
Peptide:
NIYQYG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
46-51
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.9
Area of the profile Above Threshold (AGGRESCAN):
0.84
Best Energy Score (PASTA 2.0):
-1.41
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0738 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0738
Peptide:
NKFGGP
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
263-268
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-29.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.81
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0739 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0739
Peptide:
NKGAII
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
698-703
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51., Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16938-43.
source:
AmyLoad, Waltz-DB 2.0
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.4
Area of the profile Above Threshold (AGGRESCAN):
1.28
Best Energy Score (PASTA 2.0):
-2.11
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0740 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0740
Peptide:
NKGAIK
Length:
6
Classification:
Non-amyloid
Mutation(s):
I32K
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
Literature
PMID:
25474758
Reference:
J Am Chem Soc. 2014 Dec 31;136(52):18044-51.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.2
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-39.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.2
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0741 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
I
K
C
L
S
V
E
V
Q
A
K
L
R
S
G
L
A
I
S
S
L
G
Q
C
V
E
E
L
A
L
N
S
I
D
A
E
A
K
C
V
A
V
R
V
N
M
E
T
F
Q
V
Q
V
I
D
N
G
F
G
60
61
M
G
S
D
D
V
E
K
V
G
N
R
Y
F
T
S
K
C
H
S
V
Q
D
L
E
N
P
R
F
Y
G
F
R
G
E
A
L
A
N
I
A
D
M
A
S
A
V
E
I
S
S
K
K
N
R
T
M
K
T
F
120
121
V
K
L
F
Q
S
G
K
A
L
K
A
C
E
A
D
V
T
R
A
S
A
G
T
T
V
T
V
Y
N
L
F
Y
Q
L
P
V
R
R
K
C
M
D
P
R
L
E
F
E
K
V
R
Q
R
I
E
A
L
S
L
180
181
M
H
P
S
I
S
F
S
L
R
N
D
V
S
G
S
M
V
L
Q
L
P
K
T
K
D
V
C
S
R
F
C
Q
I
Y
G
L
G
K
S
Q
K
L
R
E
I
S
F
K
Y
K
E
F
E
L
S
G
Y
I
S
240
241
S
E
A
H
Y
N
K
N
M
Q
F
L
F
V
N
K
R
L
V
L
R
T
K
L
H
K
L
I
D
F
L
L
R
K
E
S
I
I
C
K
P
K
N
G
P
T
S
R
Q
M
N
S
S
L
R
H
R
S
T
P
300
301
E
L
Y
G
I
Y
V
I
N
V
Q
C
Q
F
C
E
Y
D
V
C
M
E
P
A
K
T
L
I
E
F
Q
N
W
D
T
L
L
F
C
I
Q
E
G
V
K
M
F
L
K
Q
E
K
L
F
V
E
L
S
G
E
360
361
D
I
K
E
F
S
E
D
N
G
F
S
L
F
D
A
T
L
Q
K
R
V
T
S
D
E
R
S
N
F
Q
E
A
C
N
N
I
L
D
S
Y
E
M
F
N
L
Q
S
K
A
V
K
R
K
T
T
A
E
N
V
420
421
N
T
Q
S
S
R
D
S
E
A
T
R
K
N
T
N
D
A
F
L
Y
I
Y
E
S
G
G
P
G
H
S
K
M
T
E
P
S
L
Q
N
K
D
S
S
C
S
E
S
K
M
L
E
Q
E
T
I
V
A
S
E
480
481
A
G
E
N
E
K
H
K
K
S
F
L
E
H
S
S
L
E
N
P
C
G
T
S
L
E
M
F
L
S
P
F
Q
T
P
C
H
F
E
E
S
G
Q
D
L
E
I
W
K
E
S
T
T
V
N
G
M
A
A
N
540
541
I
L
K
N
N
R
I
Q
N
Q
P
K
R
F
K
D
A
T
E
V
G
C
Q
P
L
P
F
A
T
T
L
W
G
V
H
S
A
Q
T
E
K
E
K
K
K
E
S
S
N
C
G
R
R
N
V
F
S
Y
G
R
600
601
V
K
L
C
S
T
G
F
I
T
H
V
V
Q
N
E
K
T
K
S
T
E
T
E
H
S
F
K
N
Y
V
R
P
G
P
T
R
A
Q
E
T
F
G
N
R
T
R
H
S
V
E
T
P
D
I
K
D
L
A
S
660
661
T
L
S
K
E
S
G
Q
L
P
N
K
K
N
C
R
T
N
I
S
Y
G
L
E
N
E
P
T
A
T
Y
T
M
F
S
A
F
Q
E
G
S
K
K
S
Q
T
D
C
I
L
S
D
T
S
P
S
F
P
W
Y
720
721
R
H
V
S
N
D
S
R
K
T
D
K
L
I
G
F
S
K
P
I
V
R
K
K
L
S
L
S
S
Q
L
G
S
L
E
K
F
K
R
Q
Y
G
K
V
E
N
P
L
D
T
E
V
E
E
S
N
G
V
T
T
780
781
N
L
S
L
Q
V
E
P
D
I
L
L
K
D
K
N
R
L
E
N
S
D
V
C
K
I
T
T
M
E
H
S
D
S
D
S
S
C
Q
P
A
S
H
I
L
N
S
E
K
F
P
F
S
K
D
E
D
C
L
E
840
841
Q
Q
M
P
S
L
R
E
S
P
M
T
L
K
E
L
S
L
F
N
R
K
P
L
D
L
E
K
S
S
E
S
L
A
S
K
L
S
R
L
K
G
S
E
R
E
T
Q
T
M
G
M
M
S
R
F
N
E
L
P
900
901
N
S
D
S
S
R
K
D
S
K
L
C
S
V
L
T
Q
D
F
C
M
L
F
N
N
K
H
E
K
T
E
N
G
V
I
P
T
S
D
S
A
T
Q
D
N
S
F
N
K
N
S
K
T
H
S
N
S
N
T
T
960
961
E
N
C
V
I
S
E
T
P
L
V
L
P
Y
N
N
S
K
V
T
G
K
D
S
D
V
L
I
R
A
S
E
Q
Q
I
G
S
L
D
S
P
S
G
M
L
M
N
P
V
E
D
A
T
G
D
Q
N
G
I
C
1020
1021
F
Q
S
E
E
S
K
A
R
A
C
S
E
T
E
E
S
N
T
C
C
S
D
W
Q
R
H
F
D
V
A
L
G
R
M
V
Y
V
N
K
M
T
G
L
S
T
F
I
A
P
T
E
D
I
Q
A
A
C
T
K
1080
1081
D
L
T
T
V
A
V
D
V
V
L
E
N
G
S
Q
Y
R
C
Q
P
F
R
S
D
L
V
L
P
F
L
P
R
A
R
A
E
R
T
V
M
R
Q
D
N
R
D
T
V
D
D
T
V
S
S
E
S
L
Q
S
1140
1141
L
F
S
E
W
D
N
P
V
F
A
R
Y
P
E
V
A
V
D
V
S
S
G
Q
A
E
S
L
A
V
K
I
H
N
I
L
Y
P
Y
R
F
T
K
G
M
I
H
S
M
Q
V
L
Q
Q
V
D
N
K
F
I
1200
1201
A
C
L
M
S
T
K
T
E
E
N
G
E
A
G
G
N
L
L
V
L
V
D
Q
H
A
A
H
E
R
I
R
L
E
Q
L
I
I
D
S
Y
E
K
Q
Q
A
Q
G
S
G
R
K
K
L
L
S
S
T
L
I
1260
1261
P
P
L
E
I
T
V
T
E
E
Q
R
R
L
L
W
C
Y
H
K
N
L
E
D
L
G
L
E
F
V
F
P
D
T
S
D
S
L
V
L
V
G
K
V
P
L
C
F
V
E
R
E
A
N
E
L
R
R
G
R
1320
1321
S
T
V
T
K
S
I
V
E
E
F
I
R
E
Q
L
E
L
L
Q
T
T
G
G
I
Q
G
T
L
P
L
T
V
Q
K
V
L
A
S
Q
A
C
H
G
A
I
K
F
N
D
G
L
S
L
Q
E
S
C
R
L
1380
1381
I
E
A
L
S
S
C
Q
L
P
F
Q
C
A
H
G
R
P
S
M
L
P
L
A
D
I
D
H
L
E
Q
E
K
Q
I
K
P
N
L
T
K
L
R
K
M
A
Q
A
W
R
L
F
G
K
A
E
C
D
T
R
1440
1441
Q
S
L
Q
Q
S
M
P
P
C
E
P
P
1453
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0741
Peptide:
NLFYQL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q9UHC1
UniProt Name:
MLH3_HUMAN
Protein Name:
DNA mismatch repair protein Mlh3 (MutL protein homolog 3)
Position:
150-155
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.76
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
43.0
Area of the profile Above Threshold (AGGRESCAN):
2.85
Best Energy Score (PASTA 2.0):
-2.06
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0742 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0742
Peptide:
NLGPVL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.0
Area of the profile Above Threshold (AGGRESCAN):
0.63
Best Energy Score (PASTA 2.0):
1.93
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0743 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0743
Peptide:
NLQGYQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
109-114
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.16
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-44.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.78
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0744 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
N
D
Y
T
Q
Q
A
T
Q
S
Y
G
A
Y
P
T
Q
P
G
Q
G
Y
S
Q
Q
S
S
Q
P
Y
G
Q
Q
S
Y
S
G
Y
S
Q
S
T
D
T
S
G
Y
G
Q
S
S
Y
S
S
Y
G
Q
60
61
S
Q
N
T
G
Y
G
T
Q
S
T
P
Q
G
Y
G
S
T
G
G
Y
G
S
S
Q
S
S
Q
S
S
Y
G
Q
Q
S
S
Y
P
G
Y
G
Q
Q
P
A
P
S
S
T
S
G
S
Y
G
S
S
S
Q
S
S
120
121
S
Y
G
Q
P
Q
S
G
S
Y
S
Q
Q
P
S
Y
G
G
Q
Q
Q
S
Y
G
Q
Q
Q
S
Y
N
P
P
Q
G
Y
G
Q
Q
N
Q
Y
N
S
S
S
G
G
G
G
G
G
G
G
G
G
N
Y
G
Q
D
180
181
Q
S
S
M
S
S
G
G
G
S
G
G
G
Y
G
N
Q
D
Q
S
G
G
G
G
S
G
G
Y
G
Q
Q
D
R
G
G
R
G
R
G
G
S
G
G
G
G
G
G
G
G
G
G
Y
N
R
S
S
G
G
Y
E
240
241
P
R
G
R
G
G
G
R
G
G
R
G
G
M
G
G
S
D
R
G
G
F
N
K
F
G
G
P
R
D
Q
G
S
R
H
D
S
E
Q
D
N
S
D
N
N
T
I
F
V
Q
G
L
G
E
N
V
T
I
E
S
300
301
V
A
D
Y
F
K
Q
I
G
I
I
K
T
N
K
K
T
G
Q
P
M
I
N
L
Y
T
D
R
E
T
G
K
L
K
G
E
A
T
V
S
F
D
D
P
P
S
A
K
A
A
I
D
W
F
D
G
K
E
F
S
360
361
G
N
P
I
K
V
S
F
A
T
R
R
A
D
F
N
R
G
G
G
N
G
R
G
G
R
G
R
G
G
P
M
G
R
G
G
Y
G
G
G
G
S
G
G
G
G
R
G
G
F
P
S
G
G
G
G
G
G
G
Q
420
421
Q
R
A
G
D
W
K
C
P
N
P
T
C
E
N
M
N
F
S
W
R
N
E
C
N
Q
C
K
A
P
K
P
D
G
P
G
G
G
P
G
G
S
H
M
G
G
N
Y
G
D
D
R
R
G
G
R
G
G
Y
D
480
481
R
G
G
Y
R
G
R
G
G
D
R
G
G
F
R
G
G
R
G
G
G
D
R
G
G
F
G
P
G
K
M
D
S
R
G
E
H
R
Q
D
R
R
E
R
P
Y
526
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0744
Peptide:
NLYTDR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P35637
UniProt Name:
FUS_HUMAN
Protein Name:
RNA-binding protein FUS
Position:
323-328
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
33.33
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-29.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.25
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0745 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0745
Peptide:
NMGGGM
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
306-311
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-38.4
Area of the profile Above Threshold (AGGRESCAN):
0.06
Best Energy Score (PASTA 2.0):
2.06
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0746 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
Q
D
D
P
E
N
S
K
L
Y
D
L
L
N
S
H
L
D
V
H
G
R
S
N
E
E
P
R
Q
T
G
D
S
R
S
Q
S
S
G
N
T
G
E
N
E
E
D
I
A
F
A
S
G
L
N
G
G
T
F
60
61
D
S
M
L
E
A
L
P
D
D
L
Y
F
T
D
F
V
S
P
F
T
A
A
A
T
T
S
V
T
T
K
T
V
K
D
T
T
P
A
T
N
H
M
D
D
D
I
A
M
F
D
S
L
A
T
T
Q
P
I
D
120
121
I
A
A
S
N
Q
Q
N
G
E
I
A
Q
L
W
D
F
N
V
D
Q
F
N
M
T
P
S
N
S
S
G
S
A
T
I
S
A
P
N
S
F
T
S
D
I
P
Q
Y
N
H
G
S
L
G
N
S
V
S
K
S
180
181
S
L
F
P
Y
N
S
S
T
S
N
S
N
I
N
Q
P
S
I
N
N
N
S
N
T
N
A
Q
S
H
H
S
F
N
I
Y
K
L
Q
N
N
N
S
S
S
S
A
M
N
I
T
N
N
N
N
S
N
N
S
N
240
241
I
Q
H
P
F
L
K
K
S
D
S
I
G
L
S
S
S
N
T
T
N
S
V
R
K
N
S
L
I
K
P
M
S
S
T
S
L
A
N
F
K
R
A
A
S
V
S
S
S
I
S
N
M
E
P
S
G
Q
N
K
300
301
K
P
L
I
Q
C
F
N
C
K
T
F
K
T
P
L
W
R
R
S
P
E
G
N
T
L
C
N
A
C
G
L
F
Q
K
L
H
G
T
M
R
P
L
S
L
K
S
D
V
I
K
K
R
I
S
K
K
R
A
K
360
361
Q
T
D
P
N
I
A
Q
N
T
P
S
A
P
A
T
A
S
T
S
V
T
T
T
N
A
K
P
I
R
S
R
K
K
S
L
Q
Q
N
S
L
S
R
V
I
P
E
E
I
I
R
D
N
I
G
N
T
N
N
I
420
421
L
N
V
N
R
G
G
Y
N
F
N
S
V
P
S
P
V
L
M
N
S
Q
S
Y
N
S
S
N
A
N
F
N
G
A
S
N
A
N
L
N
S
N
N
L
M
R
H
N
S
N
T
V
T
P
N
F
R
R
S
S
480
481
R
R
S
S
T
S
S
N
T
S
S
S
S
K
S
S
S
R
S
V
V
P
I
L
P
K
P
S
P
N
S
A
N
S
Q
Q
F
N
M
N
M
N
L
M
N
T
T
N
N
V
S
A
G
N
S
V
A
S
S
P
540
541
R
I
I
S
S
A
N
F
N
S
N
S
P
L
Q
Q
N
L
L
S
N
S
F
Q
R
Q
G
M
N
I
P
R
R
K
M
S
R
N
A
S
Y
S
S
S
F
M
A
A
S
L
Q
Q
L
H
E
Q
Q
Q
V
D
600
601
V
N
S
N
T
N
T
N
S
N
R
Q
N
W
N
S
S
N
S
V
S
T
N
S
R
S
S
N
F
V
S
Q
K
P
N
F
D
I
F
N
T
P
V
D
S
P
S
V
S
R
P
S
S
R
K
S
H
T
S
L
660
661
L
S
Q
Q
L
Q
N
S
E
S
N
S
F
I
S
N
H
K
F
N
N
R
L
S
S
D
S
T
S
P
I
K
Y
E
A
D
V
S
A
G
G
K
I
S
E
D
N
S
T
K
G
S
S
K
E
S
S
A
I
A
720
721
D
E
L
D
W
L
K
F
G
I
730
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0746
Peptide:
NMNMNL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P18494
UniProt Name:
GLN3_YEAST
Protein Name:
Nitrogen regulatory protein GLN3
Position:
518-523
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.3
Area of the profile Above Threshold (AGGRESCAN):
0.14
Best Energy Score (PASTA 2.0):
-1.07
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0747 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0747
Peptide:
NNATAH
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
144-149
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-63.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0748 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
S
D
E
E
D
F
N
D
I
Y
G
D
D
K
P
T
T
T
E
E
V
K
K
E
E
E
Q
N
K
A
G
S
G
T
S
Q
L
D
Q
L
A
A
L
Q
A
L
S
S
S
L
N
K
L
N
N
P
N
S
60
61
N
N
S
S
S
N
N
S
N
Q
D
T
S
S
S
K
Q
D
G
T
A
N
D
K
E
G
S
N
E
D
T
K
N
E
K
K
Q
E
S
A
T
S
A
N
A
N
A
N
A
S
S
A
G
P
S
G
L
P
W
E
120
121
Q
L
Q
Q
T
M
S
Q
F
Q
Q
P
S
S
Q
S
P
P
Q
Q
Q
V
T
Q
T
K
E
E
R
S
K
A
D
L
S
K
E
S
C
K
M
F
I
G
G
L
N
W
D
T
T
E
D
N
L
R
E
Y
F
G
180
181
K
Y
G
T
V
T
D
L
K
I
M
K
D
P
A
T
G
R
S
R
G
F
G
F
L
S
F
E
K
P
S
S
V
D
E
V
V
K
T
Q
H
I
L
D
G
K
V
I
D
P
K
R
A
I
P
R
D
E
Q
D
240
241
K
T
G
K
I
F
V
G
G
I
G
P
D
V
R
P
K
E
F
E
E
F
F
S
Q
W
G
T
I
I
D
A
Q
L
M
L
D
K
D
T
G
Q
S
R
G
F
G
F
V
T
Y
D
S
A
D
A
V
D
R
V
300
301
C
Q
N
K
F
I
D
F
K
D
R
K
I
E
I
K
R
A
E
P
R
H
M
Q
Q
K
S
S
N
N
G
G
N
N
G
G
N
N
M
N
R
R
G
G
N
F
G
N
Q
G
D
F
N
Q
M
Y
Q
N
P
M
360
361
M
G
G
Y
N
P
M
M
N
P
Q
A
M
T
D
Y
Y
Q
K
M
Q
E
Y
Y
Q
Q
M
Q
K
Q
T
G
M
D
Y
T
Q
M
Y
Q
Q
Q
M
Q
Q
M
A
M
M
M
P
G
F
A
M
P
P
N
A
M
420
421
T
L
N
Q
P
Q
Q
D
S
N
A
T
Q
G
S
P
A
P
S
D
S
D
N
N
K
S
N
D
V
Q
T
I
G
N
T
S
N
T
D
S
G
S
P
P
L
N
L
P
N
G
P
K
G
P
S
Q
Y
N
D
D
480
481
H
N
S
G
Y
G
Y
N
R
D
R
G
D
R
D
R
N
D
R
D
R
D
Y
N
H
R
S
G
G
N
H
R
R
N
G
R
G
G
R
G
G
Y
N
R
R
N
N
G
Y
H
P
Y
N
R
534
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0748
Peptide:
NNGGNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q99383
UniProt Name:
HRP1_YEAST
Protein Name:
Nuclear polyadenylated RNA-binding protein 4 (Cleavage factor IB) (CFIB)
Position:
329-334
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.52
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-100.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.71
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0749 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0749
Peptide:
NNLQGY
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
108-113
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.17
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-41.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.72
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0750 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
T
D
K
L
I
S
E
A
E
S
H
F
S
Q
G
N
H
A
E
A
V
A
K
L
T
S
A
A
Q
S
N
P
N
D
E
Q
M
S
T
I
E
S
L
I
Q
K
I
A
G
Y
V
M
D
N
R
S
G
G
60
61
S
D
A
S
Q
D
R
A
A
G
G
G
S
S
F
M
N
T
L
M
A
D
S
K
G
S
S
Q
T
Q
L
G
K
L
A
L
L
A
T
V
M
T
H
S
S
N
K
G
S
S
N
R
G
F
D
V
G
T
V
M
120
121
S
M
L
S
G
S
G
G
G
S
Q
S
M
G
A
S
G
L
A
A
L
A
S
Q
F
F
K
S
G
N
N
S
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
S
F
T
A
L
A
S
L
180
181
A
S
S
F
M
N
S
N
N
N
N
Q
Q
G
Q
N
Q
S
S
G
G
S
S
F
G
A
L
A
S
M
A
S
S
F
M
H
S
N
N
N
Q
N
S
N
N
S
Q
Q
G
Y
N
Q
S
Y
Q
N
G
N
Q
N
240
241
S
Q
G
Y
N
N
Q
Q
Y
Q
G
G
N
G
G
Y
Q
Q
Q
Q
G
Q
S
G
G
A
F
S
S
L
A
S
M
A
Q
S
Y
L
G
G
G
Q
T
Q
S
N
Q
Q
Q
Y
N
Q
Q
G
Q
N
N
Q
Q
Q
300
301
Y
Q
Q
Q
G
Q
N
Y
Q
H
Q
Q
Q
G
Q
Q
Q
Q
Q
G
H
S
S
S
F
S
A
L
A
S
M
A
S
S
Y
L
G
N
N
S
N
S
N
S
S
Y
G
G
Q
Q
Q
A
N
E
Y
G
R
P
Q
Q
360
361
N
G
Q
Q
Q
S
N
E
Y
G
R
P
Q
Y
G
G
N
Q
N
S
N
G
Q
H
E
S
F
N
F
S
G
N
F
S
Q
Q
N
N
N
G
N
Q
N
R
Y
405
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0750
Peptide:
NNNGNQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P25367
UniProt Name:
RNQ1_YEAST
Protein Name:
[PIN+] prion protein RNQ1
Position:
397-402
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-114.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.4
Aggregate Orientation (PASTA 2.0):
Parallel
