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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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Contact Us
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 691 to 720 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-0691
NATVYV
6
amyloid
Apolipoprotein A-I (ApoA-I)
P02647
L38N
Switch Lab
SwitchLab
Waltz-DB 2.0
P-0692
NDFQKQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0693
NDNNNN
6
Non-amyloid
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Q12221
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0694
NDNNSN
6
Non-amyloid
Transcription factor RLM1
Q12224
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0695
NEFIIT
6
Non-amyloid
Bone marrow proteoglycan (BMPG) (Proteoglycan 2)
P13727
CPAD, WALTZ
P-0696
NENGNA
6
Non-amyloid
Serine/threonine-protein kinase KSP1
P38691
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0697
NFFIQS
6
Non-amyloid
Cohesin subunit SA-3
Q9UJ98
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0698
NFFWLL
6
Non-amyloid
Vasoactive intestinal polypeptide receptor 1 (VIP-R-1)
P32241
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0699
NFGAFS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0700
NFGAIL
6
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0701
NFGEFS
6
amyloid
TAR DNA-binding protein 43
Q13148
A315E
Nat Struct Mol Biol. 2018 Jun;25(6):463-471.
29786080
Waltz-DB 2.0
P-0702
NFGSVQ
6
Amyloid
No
Amyloid. 2004 Jun;11(2):81-9
15478463
CPAD, Waltz-DB 2.0, AmyLoad
P-0703
NFGTFS
6
Non-amyloid
TAR DNA-binding protein 43 (TDP-43)
Q13148
A315T
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0704
NFLVHS
6
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Nat Struct Mol Biol. 2009 Sep;16(9):973-8.
19684598
Waltz-DB 2.0, AmyLoad
P-0705
NFNNGN
6
Non-amyloid
Serine/threonine-protein kinase KSP1
P38691
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0706
NFNYNN
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0707
NFVNYS
6
Amyloid
Cadherin EGF LAG seven-pass G-type receptor 3
Q9NYQ7
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-0708
NGAAVD
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0709
NGADVG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0710
NGERIE
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0711
NGIVIV
6
Non-amyloid
Agglutinin-like protein 1 (Adhesin 1)
Q5A8T4
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0712
NGKSNF
6
Non-amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
P-0713
NGNLSN
6
Non-amyloid
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Q12221
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0714
NGNLTS
6
Non-amyloid
SWI/SNF chromatin-remodeling complex subunit SWI1
P09547
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0715
NGNNSN
6
Non-amyloid
Asparagine-rich protein (Protein ARP)
P32770
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0716
NGNQNR
6
Non-amyloid
[PIN+] prion protein RNQ1
P25367
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0717
NGNQQQ
6
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0718
NHFCIQ
6
Amyloid
CD180 antigen (Lymphocyte antigen 64)
Q99467
BMC Bioinformatics. 2013;14 Suppl 8:S6.
23815227
CPAD, Waltz-DB 2.0
P-0719
NHGGGG
6
Non-amyloid
Major curlin subunit
P28307
No
Switch Lab
SwitchLab
Waltz-DB 2.0, AmyLoad
P-0720
NHVTLS
6
Amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, Waltz-DB 2.0, AmyLoad
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Entry: P-0691 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
A
V
L
T
L
A
V
L
F
L
T
G
S
Q
A
R
H
F
W
Q
Q
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
60
61
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
120
121
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
180
181
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
240
241
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
N
T
Q
267
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0691
Peptide:
NATVYV
Length:
6
Classification:
amyloid
Mutation(s):
L38N
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I (ApoA-I)
Position:
38-43
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.31
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
28.5
Area of the profile Above Threshold (AGGRESCAN):
2.4
Best Energy Score (PASTA 2.0):
-4.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0692 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0692
Peptide:
NDFQKQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
127-132
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
16.67
NuAPRpred:
-0.49
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-69.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.69
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0693 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
N
K
R
L
Y
N
G
N
L
S
N
I
P
E
V
I
D
P
G
I
T
I
P
I
Y
E
E
D
I
R
N
D
T
R
M
N
T
N
A
R
S
V
R
V
S
D
K
R
G
R
S
S
S
T
S
P
Q
K
60
61
I
G
S
Y
R
T
R
A
G
R
F
S
D
T
L
T
N
L
L
P
S
I
S
A
K
L
H
H
S
K
K
S
T
P
V
V
V
V
P
P
T
S
S
T
P
D
S
L
N
S
T
T
Y
A
P
R
V
S
S
D
120
121
S
F
T
V
A
T
P
L
S
L
Q
S
T
T
T
R
T
R
T
R
N
N
T
V
S
S
Q
I
T
A
S
S
S
L
T
T
D
V
G
N
A
T
S
A
N
I
W
S
A
N
A
E
S
N
T
S
S
S
P
L
180
181
F
D
Y
P
L
A
T
S
Y
F
E
P
L
T
R
F
K
S
T
D
N
Y
T
L
P
Q
T
A
Q
L
N
S
F
L
E
K
N
G
N
P
N
I
W
S
S
A
G
N
S
N
T
D
H
L
N
T
P
I
V
N
240
241
R
Q
R
S
Q
S
Q
S
T
T
N
R
V
Y
T
D
A
P
Y
Y
Q
Q
P
A
Q
N
Y
Q
V
Q
V
P
P
R
V
P
K
S
T
S
I
S
P
V
I
L
D
D
V
D
P
A
S
I
N
W
I
T
A
N
300
301
Q
K
V
P
L
V
N
Q
I
S
A
L
L
P
T
N
T
I
S
I
S
N
V
F
P
L
Q
P
T
Q
Q
H
Q
Q
N
A
V
N
L
T
S
T
S
L
A
T
L
C
S
Q
Y
G
K
V
L
S
A
R
T
L
360
361
R
G
L
N
M
A
L
V
E
F
S
T
V
E
S
A
I
C
A
L
E
A
L
Q
G
K
E
L
S
K
V
G
A
P
S
T
V
S
F
A
R
V
L
P
M
Y
E
Q
P
L
N
V
N
G
F
N
N
T
P
K
420
421
Q
P
L
L
Q
E
Q
L
N
H
G
V
L
N
Y
Q
L
Q
Q
S
L
Q
Q
P
E
L
Q
Q
Q
P
T
S
F
N
Q
P
N
L
T
Y
C
N
P
T
Q
N
L
S
H
L
Q
L
S
S
N
E
N
E
P
Y
480
481
P
F
P
L
P
P
P
S
L
S
D
S
K
K
D
I
L
H
T
I
S
S
F
K
L
E
Y
D
H
L
E
L
N
H
L
L
Q
N
A
L
K
N
K
G
V
S
D
T
N
Y
F
G
P
L
P
E
H
N
S
K
540
541
V
P
K
R
K
D
T
F
D
A
P
K
L
R
E
L
R
K
Q
F
D
S
N
S
L
S
T
I
E
M
E
Q
L
A
I
V
M
L
D
Q
L
P
E
L
S
S
D
Y
L
G
N
T
V
I
Q
K
L
F
E
N
600
601
S
S
N
I
I
R
D
I
M
L
R
K
C
N
K
Y
L
T
S
M
G
V
H
K
N
G
T
W
V
C
Q
K
I
I
K
M
A
N
T
P
R
Q
I
N
L
V
T
S
G
V
S
D
Y
C
T
P
L
F
N
D
660
661
Q
F
G
N
Y
V
I
Q
G
I
L
K
F
G
F
P
W
N
S
F
I
F
E
S
V
L
S
H
F
W
T
I
V
Q
N
R
Y
G
S
R
A
V
R
A
C
L
E
A
D
S
I
I
T
Q
C
Q
L
L
T
I
720
721
T
S
L
I
I
V
L
S
P
Y
L
A
T
D
T
N
G
T
L
L
I
T
W
L
L
D
T
C
T
L
P
N
K
N
L
I
L
C
D
K
L
V
N
K
N
L
V
K
L
C
C
H
K
L
G
S
L
T
V
L
780
781
K
I
L
N
L
R
G
G
E
E
E
A
L
S
K
N
K
I
I
H
A
I
F
D
G
P
I
S
S
D
S
I
L
F
Q
I
L
D
E
G
N
Y
G
P
T
F
I
Y
K
V
L
T
S
R
I
L
D
N
S
V
840
841
R
D
E
A
I
T
K
I
R
Q
L
I
L
N
S
N
I
N
L
Q
S
R
Q
L
L
E
E
V
G
L
S
S
A
G
I
S
P
K
Q
S
S
K
N
H
R
K
Q
H
P
Q
G
F
H
S
P
G
R
A
R
G
900
901
V
S
V
S
S
V
R
S
S
N
S
R
H
N
S
V
I
Q
M
N
N
A
G
P
T
P
A
L
N
F
N
P
A
P
M
S
E
I
N
S
Y
F
N
N
Q
Q
V
V
Y
S
G
N
Q
N
Q
N
Q
N
G
N
960
961
S
N
G
L
D
E
L
N
S
Q
F
D
S
F
R
I
A
N
G
T
N
L
S
L
P
I
V
N
L
P
N
V
S
N
N
N
N
N
Y
N
N
S
G
Y
S
S
Q
M
N
P
L
S
R
S
V
S
H
N
N
N
1020
1021
N
N
T
N
N
Y
N
N
N
D
N
D
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
S
N
N
S
N
N
N
N
N
N
D
T
S
L
Y
R
Y
R
S
Y
G
Y
1075
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0693
Peptide:
NDNNNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12221
UniProt Name:
PUF2_YEAST
Protein Name:
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Position:
1031-1036
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.57
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-138.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.09
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0694 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
G
R
R
K
I
E
I
Q
R
I
S
D
D
R
N
R
A
V
T
F
I
K
R
K
A
G
L
F
K
K
A
H
E
L
S
V
L
C
Q
V
D
I
A
V
I
I
L
G
S
N
N
T
F
Y
E
F
S
S
V
60
61
D
T
N
D
L
I
Y
H
Y
Q
N
D
K
N
L
L
H
E
V
K
D
P
S
D
Y
G
D
F
H
K
S
A
S
V
N
I
N
Q
D
L
L
R
S
S
M
S
N
K
P
S
K
S
N
V
K
G
M
N
Q
S
120
121
E
N
D
D
D
E
N
N
D
E
D
D
D
D
H
G
N
F
E
R
N
S
N
M
H
S
N
K
K
A
S
D
K
N
I
P
S
A
H
M
K
L
L
S
P
T
A
L
I
S
K
M
D
G
S
E
Q
N
K
R
180
181
H
P
E
N
A
L
P
P
L
Q
H
L
K
R
L
K
P
D
P
L
Q
I
S
R
T
P
Q
Q
Q
Q
Q
Q
N
I
S
R
P
Y
H
S
S
M
Y
N
L
N
Q
P
S
S
S
S
S
S
P
S
T
M
D
F
240
241
P
K
L
P
S
F
Q
N
S
S
F
N
G
R
P
P
P
I
S
I
S
P
N
K
F
S
K
P
F
T
N
A
S
S
R
T
P
K
Q
E
H
K
I
N
N
S
G
S
N
N
N
D
N
S
N
Y
T
Q
S
P
300
301
S
N
S
L
E
D
S
I
Q
Q
T
V
K
A
R
R
K
L
S
A
R
P
V
L
R
V
R
I
P
N
N
N
F
S
S
N
S
A
I
P
S
E
P
S
S
A
S
S
T
S
A
N
G
N
S
M
G
S
S
Q
360
361
I
M
K
E
N
K
T
S
R
S
S
K
I
S
P
L
S
A
S
A
S
G
P
L
T
L
Q
K
G
N
N
G
R
M
V
I
K
L
P
N
A
N
A
P
N
G
S
N
N
G
N
G
S
N
N
N
N
H
P
Y
420
421
P
F
G
S
G
S
S
P
L
F
S
A
T
Q
P
Y
I
A
T
P
L
Q
P
S
N
I
P
G
G
P
F
Q
Q
N
T
S
F
L
A
Q
R
Q
T
Q
Q
Y
Q
Q
M
S
F
K
K
Q
S
Q
T
V
P
L
480
481
T
T
T
L
T
G
R
P
P
S
T
F
S
G
P
E
T
S
N
G
P
P
T
G
S
L
P
S
K
F
V
H
D
L
M
S
N
S
P
N
V
S
S
I
S
M
F
P
D
W
S
M
G
P
N
S
A
K
P
G
540
541
N
T
N
N
P
G
T
F
P
P
V
Q
T
A
V
N
N
G
N
S
S
N
I
S
S
T
N
N
T
N
N
N
N
N
N
N
N
N
N
S
S
N
N
N
S
N
N
G
N
D
N
N
S
N
N
S
N
N
S
Y
600
601
Y
S
N
N
E
D
A
P
V
N
G
A
A
I
S
E
H
T
T
D
G
D
S
N
N
Q
S
N
S
S
T
Y
D
A
A
A
T
A
Y
N
G
N
T
G
L
T
P
Y
I
N
T
A
Q
T
P
L
G
T
K
F
660
661
F
N
F
S
T
D
I
S
G
E
K
N
S
S
K
I
676
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0694
Peptide:
NDNNSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12224
UniProt Name:
RLM1_YEAST
Protein Name:
Transcription factor RLM1
Position:
589-594
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.58
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-124.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0695 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0695
Peptide:
NEFIIT
Length:
6
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P13727
UniProt Name:
EMBP_HUMAN
Protein Name:
Bone marrow proteoglycan (BMPG) (Proteoglycan 2)
Position:
Literature
PMID:
Reference:
source:
CPAD, WALTZ
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
0.74
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
44.3
Area of the profile Above Threshold (AGGRESCAN):
3.04
Best Energy Score (PASTA 2.0):
-4.92
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0696 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
L
D
Y
E
I
Y
K
E
G
G
I
L
N
N
R
Y
Q
K
I
E
D
I
S
E
G
S
Y
G
Y
V
S
L
A
K
D
V
R
E
K
R
L
V
A
V
K
Y
I
F
K
L
E
D
D
G
Q
Y
D
G
60
61
P
Q
D
D
E
N
D
C
D
S
S
D
C
D
D
D
E
D
T
K
V
D
T
D
R
H
E
N
E
N
G
N
A
S
S
N
N
G
S
S
R
E
K
K
H
N
L
Y
K
H
K
K
S
L
I
S
S
K
V
K
120
121
S
R
L
S
N
N
I
C
L
E
A
M
Y
E
V
D
I
Q
T
K
I
G
R
H
Q
N
I
A
A
L
L
D
F
F
D
S
Y
I
I
M
E
Y
C
S
G
G
D
L
Y
E
A
I
K
A
D
A
V
P
K
K
180
181
T
K
S
I
T
H
I
I
T
Q
I
M
D
A
I
E
Y
V
H
N
K
G
I
Y
H
R
D
I
K
P
E
N
I
L
I
S
G
I
D
W
T
I
K
L
T
D
W
G
L
A
T
T
D
K
T
S
M
D
R
N
240
241
V
G
S
E
R
Y
M
S
P
E
L
F
D
S
N
L
D
I
K
E
R
K
E
P
Y
D
C
A
K
V
D
L
W
A
M
G
I
V
F
L
N
I
V
F
H
K
N
P
F
S
I
A
N
Q
S
D
K
S
F
C
300
301
Y
F
A
A
N
R
E
A
L
F
D
V
F
S
T
M
A
Y
D
F
F
Q
V
L
R
Y
S
L
T
I
D
P
A
N
R
D
L
K
M
M
R
T
E
L
Q
N
L
S
E
Y
T
L
D
D
E
Y
Y
N
N
L
360
361
D
E
G
Y
E
E
T
M
I
D
G
L
P
P
Q
P
V
P
P
S
S
A
P
V
S
L
P
T
P
I
S
S
S
N
K
Q
H
M
P
E
F
K
K
D
F
N
F
N
N
V
N
E
R
K
R
S
D
V
S
Q
420
421
N
Q
N
V
A
S
G
F
F
K
K
P
S
T
Q
Q
Q
K
F
F
N
Q
G
Y
N
T
T
L
S
T
H
E
R
A
K
S
A
P
K
F
K
F
K
K
R
N
K
Y
G
R
T
D
N
Q
F
S
K
P
V
N
480
481
I
E
D
R
K
K
S
K
I
L
K
K
S
R
K
P
L
G
I
P
T
P
N
T
H
M
N
N
F
F
H
D
Y
K
A
R
D
E
F
N
T
R
D
F
F
T
P
P
S
V
Q
H
R
Y
M
E
G
F
S
N
540
541
N
N
N
K
Q
Y
R
Q
N
R
N
Y
N
N
N
N
N
N
S
N
N
N
H
G
S
N
Y
N
N
F
N
N
G
N
S
Y
I
K
G
W
N
K
N
F
N
K
Y
R
R
P
S
S
S
S
Y
T
G
K
S
P
600
601
L
S
R
Y
N
M
S
Y
N
H
N
N
N
S
S
I
N
G
Y
A
R
R
G
S
T
T
T
V
Q
H
S
P
G
A
Y
I
P
P
N
A
R
N
H
H
V
S
P
T
N
Q
F
L
R
V
P
Q
S
T
A
P
660
661
D
I
S
T
V
L
G
G
K
P
S
Y
Q
E
H
Y
T
Q
D
S
M
D
S
E
G
D
H
D
S
D
D
V
L
F
T
L
E
E
G
D
H
D
F
V
N
G
M
D
N
L
S
I
N
D
H
L
P
H
T
T
720
721
V
G
S
H
N
E
V
F
V
H
A
S
T
N
H
N
N
N
G
N
N
N
H
I
D
T
N
S
T
T
N
Q
Y
H
R
Q
Y
I
P
P
P
L
T
T
S
L
H
I
N
N
N
N
N
E
S
N
E
L
P
D
780
781
L
L
K
S
P
A
S
S
E
A
H
L
N
L
S
S
G
P
I
D
P
I
L
T
G
N
I
G
N
R
Y
S
H
S
S
D
S
K
E
L
E
Q
E
R
R
L
S
M
E
Q
K
F
K
N
G
V
Y
V
P
P
840
841
H
H
R
K
S
F
N
L
G
T
Q
V
P
P
M
N
M
K
T
S
N
E
A
T
L
S
V
S
H
N
S
V
N
F
G
G
S
Y
N
S
R
R
S
S
A
N
E
S
N
P
L
H
M
N
K
A
L
E
K
L
900
901
S
S
S
P
G
A
K
S
S
F
V
G
F
P
K
P
L
L
P
R
N
H
S
S
T
T
I
A
L
Q
N
E
D
V
F
A
D
S
N
N
D
A
I
I
F
E
D
E
E
Y
E
G
E
S
D
K
M
A
H
G
960
961
K
M
E
G
G
D
N
E
S
S
S
T
S
P
D
E
R
Q
I
F
G
P
Y
E
I
Y
A
Q
T
F
A
G
S
T
H
D
K
K
L
G
A
G
R
K
T
S
I
Q
D
E
M
V
G
S
L
E
Q
Y
K
N
1020
1021
N
W
L
I
L
Q
Q
Q
D
1029
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0696
Peptide:
NENGNA
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P38691
UniProt Name:
KSP1_YEAST
Protein Name:
Serine/threonine-protein kinase KSP1
Position:
88-93
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-104.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0697 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
S
P
L
Q
R
A
V
G
D
T
K
R
A
L
S
A
S
S
S
S
S
A
S
L
P
F
D
D
R
D
S
N
H
T
S
E
G
N
G
D
S
L
L
A
D
E
D
T
D
F
E
D
S
L
N
R
N
V
60
61
K
K
R
A
A
K
R
P
P
K
T
T
P
V
A
K
H
P
K
K
G
S
R
V
V
H
R
H
S
R
K
Q
S
E
P
P
A
N
D
L
F
N
A
V
K
A
A
K
S
D
M
Q
S
L
V
D
E
W
L
D
120
121
S
Y
K
Q
D
Q
D
A
G
F
L
E
L
V
N
F
F
I
Q
S
C
G
C
K
G
I
V
T
P
E
M
F
K
K
M
S
N
S
E
I
I
Q
H
L
T
E
Q
F
N
E
D
S
G
D
Y
P
L
I
A
P
180
181
G
P
S
W
K
K
F
Q
G
S
F
C
E
F
V
R
T
L
V
C
Q
C
Q
Y
S
L
L
Y
D
G
F
P
M
D
D
L
I
S
L
L
T
G
L
S
D
S
Q
V
R
A
F
R
H
T
S
T
L
A
A
M
240
241
K
L
M
T
S
L
V
K
V
A
L
Q
L
S
V
H
Q
D
N
N
Q
R
Q
Y
E
A
E
R
N
K
G
P
G
Q
R
A
P
E
R
L
E
S
L
L
E
K
R
K
E
L
Q
E
H
Q
E
E
I
E
G
M
300
301
M
N
A
L
F
R
G
V
F
V
H
R
Y
R
D
V
L
P
E
I
R
A
I
C
I
E
E
I
G
C
W
M
Q
S
Y
S
T
S
F
L
T
D
S
Y
L
K
Y
I
G
W
T
L
H
D
K
H
R
E
V
R
360
361
L
K
C
V
K
A
L
K
G
L
Y
G
N
R
D
L
T
T
R
L
E
L
F
T
S
R
F
K
D
R
M
V
S
M
V
M
D
R
E
Y
D
V
A
V
E
A
V
R
L
L
I
L
I
L
K
N
M
E
G
V
420
421
L
T
D
A
D
C
E
S
V
Y
P
V
V
Y
A
S
H
R
G
L
A
S
A
A
G
E
F
L
Y
W
K
L
F
Y
P
E
C
E
I
R
M
M
G
G
R
E
Q
R
Q
S
P
G
A
Q
R
T
F
F
Q
L
480
481
L
L
S
F
F
V
E
S
E
L
H
D
H
A
A
Y
L
V
D
S
L
W
D
C
A
G
A
R
L
K
D
W
E
G
L
T
S
L
L
L
E
K
D
Q
N
L
G
D
V
Q
E
S
T
L
I
E
I
L
V
S
540
541
S
A
R
Q
A
S
E
G
H
P
P
V
G
R
V
T
G
R
K
G
L
T
S
K
E
R
K
T
Q
A
D
D
R
V
K
L
T
E
H
L
I
P
L
L
P
Q
L
L
A
K
F
S
A
D
A
E
K
V
T
P
600
601
L
L
Q
L
L
S
C
F
D
L
H
I
Y
C
T
G
R
L
E
K
H
L
E
L
F
L
Q
Q
L
Q
E
V
V
V
K
H
A
E
P
A
V
L
E
A
G
A
H
A
L
Y
L
L
C
N
P
E
F
T
F
F
660
661
S
R
A
D
F
A
R
S
Q
L
V
D
L
L
T
D
R
F
Q
Q
E
L
E
E
L
L
Q
S
S
F
L
D
E
D
E
V
Y
N
L
A
A
T
L
K
R
L
S
A
F
Y
N
T
H
D
L
T
R
W
E
L
720
721
Y
E
P
C
C
Q
L
L
Q
K
A
V
D
T
G
E
V
P
H
Q
V
I
L
P
A
L
T
L
V
Y
F
S
I
L
W
T
L
T
H
I
S
K
S
D
A
S
Q
K
Q
L
S
S
L
R
D
R
M
V
A
F
780
781
C
E
L
C
Q
S
C
L
S
D
V
D
T
E
I
Q
E
Q
A
F
V
L
L
S
D
L
L
L
I
F
S
P
Q
M
I
V
G
G
R
D
F
L
R
P
L
V
F
F
P
E
A
T
L
Q
S
E
L
A
S
F
840
841
L
M
D
H
V
F
I
Q
P
G
D
L
G
S
G
D
S
Q
E
D
H
L
Q
I
E
R
L
H
Q
R
R
R
L
L
A
G
F
C
K
L
L
L
Y
G
V
L
E
M
D
A
A
S
D
V
F
K
H
Y
N
K
900
901
F
Y
N
D
Y
G
D
I
I
K
E
T
L
T
R
A
R
Q
I
D
R
S
H
C
S
R
I
L
L
L
S
L
K
Q
L
Y
T
E
L
L
Q
E
H
G
P
Q
G
L
N
E
L
P
A
F
I
E
M
R
D
L
960
961
A
R
R
F
A
L
S
F
G
P
Q
Q
L
Q
N
R
D
L
V
V
M
L
H
K
E
G
I
Q
F
S
L
S
E
L
P
P
A
G
S
S
N
Q
P
P
N
L
A
F
L
E
L
L
S
E
F
S
P
R
L
F
1020
1021
H
Q
D
K
Q
L
L
L
S
Y
L
E
K
C
L
Q
H
V
S
Q
A
P
G
H
P
W
G
P
V
T
T
Y
C
H
S
L
S
P
V
E
N
T
A
E
T
S
P
Q
V
L
P
S
S
K
R
R
R
V
E
G
1080
1081
P
A
K
P
N
R
E
D
V
S
S
S
Q
E
E
S
L
Q
L
N
S
I
P
P
T
P
T
L
T
S
T
A
V
K
S
R
Q
P
L
W
G
L
K
E
M
E
E
E
D
G
S
E
L
D
F
A
Q
G
Q
P
1140
1141
V
A
G
T
E
R
S
R
F
L
G
P
Q
Y
F
Q
T
P
H
N
P
S
G
P
G
L
G
N
Q
L
M
R
L
S
L
M
E
E
D
E
E
E
E
L
E
I
Q
D
E
S
N
E
E
R
Q
D
T
D
M
Q
1200
1201
A
S
S
Y
S
S
T
S
E
R
G
L
D
L
L
D
S
T
E
L
D
I
E
D
F
1225
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0697
Peptide:
NFFIQS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q9UJ98
UniProt Name:
STAG3_HUMAN
Protein Name:
Cohesin subunit SA-3
Position:
135-140
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.63
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
44.5
Area of the profile Above Threshold (AGGRESCAN):
3.04
Best Energy Score (PASTA 2.0):
-3.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0698 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
S
P
L
P
A
R
W
L
C
V
L
A
G
A
L
A
W
A
L
G
P
A
G
G
Q
A
A
R
L
Q
E
E
C
D
Y
V
Q
M
I
E
V
Q
H
K
Q
C
L
E
E
A
Q
L
E
N
E
T
60
61
I
G
C
S
K
M
W
D
N
L
T
C
W
P
A
T
P
R
G
Q
V
V
V
L
A
C
P
L
I
F
K
L
F
S
S
I
Q
G
R
N
V
S
R
S
C
T
D
E
G
W
T
H
L
E
P
G
P
Y
P
I
120
121
A
C
G
L
D
D
K
A
A
S
L
D
E
Q
Q
T
M
F
Y
G
S
V
K
T
G
Y
T
I
G
Y
G
L
S
L
A
T
L
L
V
A
T
A
I
L
S
L
F
R
K
L
H
C
T
R
N
Y
I
H
M
H
180
181
L
F
I
S
F
I
L
R
A
A
A
V
F
I
K
D
L
A
L
F
D
S
G
E
S
D
Q
C
S
E
G
S
V
G
C
K
A
A
M
V
F
F
Q
Y
C
V
M
A
N
F
F
W
L
L
V
E
G
L
Y
L
240
241
Y
T
L
L
A
V
S
F
F
S
E
R
K
Y
F
W
G
Y
I
L
I
G
W
G
V
P
S
T
F
T
M
V
W
T
I
A
R
I
H
F
E
D
Y
G
C
W
D
T
I
N
S
S
L
W
W
I
I
K
G
P
300
301
I
L
T
S
I
L
V
N
F
I
L
F
I
C
I
I
R
I
L
L
Q
K
L
R
P
P
D
I
R
K
S
D
S
S
P
Y
S
R
L
A
R
S
T
L
L
L
I
P
L
F
G
V
H
Y
I
M
F
A
F
F
360
361
P
D
N
F
K
P
E
V
K
M
V
F
E
L
V
V
G
S
F
Q
G
F
V
V
A
I
L
Y
C
F
L
N
G
E
V
Q
A
E
L
R
R
K
W
R
R
W
H
L
Q
G
V
L
G
W
N
P
K
Y
R
H
420
421
P
S
G
G
S
N
G
A
T
C
S
T
Q
V
S
M
L
T
R
V
S
P
G
A
R
R
S
S
S
F
Q
A
E
V
S
L
V
457
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0698
Peptide:
NFFWLL
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32241
UniProt Name:
VIPR1_HUMAN
Protein Name:
Vasoactive intestinal polypeptide receptor 1 (VIP-R-1)
Position:
229-234
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
83.33
NuAPRpred:
0.93
Tango:
4.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
80.3
Area of the profile Above Threshold (AGGRESCAN):
5.11
Best Energy Score (PASTA 2.0):
-4.19
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0699 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0699
Peptide:
NFGAFS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
312-317
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
-0.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.3
Area of the profile Above Threshold (AGGRESCAN):
0.9
Best Energy Score (PASTA 2.0):
0.06
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0700 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0700
Peptide:
NFGAIL
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
55-60
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
0.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
19.0
Area of the profile Above Threshold (AGGRESCAN):
1.92
Best Energy Score (PASTA 2.0):
-1.78
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0701 Classification: amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0701
Peptide:
NFGEFS
Length:
6
Classification:
amyloid
Mutation(s):
A315E
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43
Position:
312-317
Literature
PMID:
29786080
Reference:
Nat Struct Mol Biol. 2018 Jun;25(6):463-471.
source:
Waltz-DB 2.0
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.13
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.2
Area of the profile Above Threshold (AGGRESCAN):
0.34
Best Energy Score (PASTA 2.0):
1.08
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0702 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0702
Peptide:
NFGSVQ
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
15478463
Reference:
Amyloid. 2004 Jun;11(2):81-9
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.3
Area of the profile Above Threshold (AGGRESCAN):
0.54
Best Energy Score (PASTA 2.0):
-0.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0703 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
E
Y
I
R
V
T
E
D
E
N
D
E
P
I
E
I
P
S
E
D
D
G
T
V
L
L
S
T
V
T
A
Q
F
P
G
A
C
G
L
R
Y
R
N
P
V
S
Q
C
M
R
G
V
R
L
V
E
G
I
60
61
L
H
A
P
D
A
G
W
G
N
L
V
Y
V
V
N
Y
P
K
D
N
K
R
K
M
D
E
T
D
A
S
S
A
V
K
V
K
R
A
V
Q
K
T
S
D
L
I
V
L
G
L
P
W
K
T
T
E
Q
D
L
120
121
K
E
Y
F
S
T
F
G
E
V
L
M
V
Q
V
K
K
D
L
K
T
G
H
S
K
G
F
G
F
V
R
F
T
E
Y
E
T
Q
V
K
V
M
S
Q
R
H
M
I
D
G
R
W
C
D
C
K
L
P
N
S
180
181
K
Q
S
Q
D
E
P
L
R
S
R
K
V
F
V
G
R
C
T
E
D
M
T
E
D
E
L
R
E
F
F
S
Q
Y
G
D
V
M
D
V
F
I
P
K
P
F
R
A
F
A
F
V
T
F
A
D
D
Q
I
A
240
241
Q
S
L
C
G
E
D
L
I
I
K
G
I
S
V
H
I
S
N
A
E
P
K
H
N
S
N
R
Q
L
E
R
S
G
R
F
G
G
N
P
G
G
F
G
N
Q
G
G
F
G
N
S
R
G
G
G
A
G
L
G
300
301
N
N
Q
G
S
N
M
G
G
G
M
N
F
G
A
F
S
I
N
P
A
M
M
A
A
A
Q
A
A
L
Q
S
S
W
G
M
M
G
M
L
A
S
Q
Q
N
Q
S
G
P
S
G
N
N
Q
N
Q
G
N
M
Q
360
361
R
E
P
N
Q
A
F
G
S
G
N
N
S
Y
S
G
S
N
S
G
A
A
I
G
W
G
S
A
S
N
A
G
S
G
S
G
F
N
G
G
F
G
S
S
M
D
S
K
S
S
G
W
G
M
414
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0703
Peptide:
NFGTFS
Length:
6
Classification:
Non-amyloid
Mutation(s):
A315T
Structure(s):
No structures
Protein Information
UniProt ID:
Q13148
UniProt Name:
TADBP_HUMAN
Protein Name:
TAR DNA-binding protein 43 (TDP-43)
Position:
312-317
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.1
Area of the profile Above Threshold (AGGRESCAN):
0.85
Best Energy Score (PASTA 2.0):
-0.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0704 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0704
Peptide:
NFLVHS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
3FR1
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
47-52
Literature
PMID:
19684598
Reference:
Nat Struct Mol Biol. 2009 Sep;16(9):973-8.
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
35.1
Area of the profile Above Threshold (AGGRESCAN):
2.42
Best Energy Score (PASTA 2.0):
-3.63
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0705 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
T
L
D
Y
E
I
Y
K
E
G
G
I
L
N
N
R
Y
Q
K
I
E
D
I
S
E
G
S
Y
G
Y
V
S
L
A
K
D
V
R
E
K
R
L
V
A
V
K
Y
I
F
K
L
E
D
D
G
Q
Y
D
G
60
61
P
Q
D
D
E
N
D
C
D
S
S
D
C
D
D
D
E
D
T
K
V
D
T
D
R
H
E
N
E
N
G
N
A
S
S
N
N
G
S
S
R
E
K
K
H
N
L
Y
K
H
K
K
S
L
I
S
S
K
V
K
120
121
S
R
L
S
N
N
I
C
L
E
A
M
Y
E
V
D
I
Q
T
K
I
G
R
H
Q
N
I
A
A
L
L
D
F
F
D
S
Y
I
I
M
E
Y
C
S
G
G
D
L
Y
E
A
I
K
A
D
A
V
P
K
K
180
181
T
K
S
I
T
H
I
I
T
Q
I
M
D
A
I
E
Y
V
H
N
K
G
I
Y
H
R
D
I
K
P
E
N
I
L
I
S
G
I
D
W
T
I
K
L
T
D
W
G
L
A
T
T
D
K
T
S
M
D
R
N
240
241
V
G
S
E
R
Y
M
S
P
E
L
F
D
S
N
L
D
I
K
E
R
K
E
P
Y
D
C
A
K
V
D
L
W
A
M
G
I
V
F
L
N
I
V
F
H
K
N
P
F
S
I
A
N
Q
S
D
K
S
F
C
300
301
Y
F
A
A
N
R
E
A
L
F
D
V
F
S
T
M
A
Y
D
F
F
Q
V
L
R
Y
S
L
T
I
D
P
A
N
R
D
L
K
M
M
R
T
E
L
Q
N
L
S
E
Y
T
L
D
D
E
Y
Y
N
N
L
360
361
D
E
G
Y
E
E
T
M
I
D
G
L
P
P
Q
P
V
P
P
S
S
A
P
V
S
L
P
T
P
I
S
S
S
N
K
Q
H
M
P
E
F
K
K
D
F
N
F
N
N
V
N
E
R
K
R
S
D
V
S
Q
420
421
N
Q
N
V
A
S
G
F
F
K
K
P
S
T
Q
Q
Q
K
F
F
N
Q
G
Y
N
T
T
L
S
T
H
E
R
A
K
S
A
P
K
F
K
F
K
K
R
N
K
Y
G
R
T
D
N
Q
F
S
K
P
V
N
480
481
I
E
D
R
K
K
S
K
I
L
K
K
S
R
K
P
L
G
I
P
T
P
N
T
H
M
N
N
F
F
H
D
Y
K
A
R
D
E
F
N
T
R
D
F
F
T
P
P
S
V
Q
H
R
Y
M
E
G
F
S
N
540
541
N
N
N
K
Q
Y
R
Q
N
R
N
Y
N
N
N
N
N
N
S
N
N
N
H
G
S
N
Y
N
N
F
N
N
G
N
S
Y
I
K
G
W
N
K
N
F
N
K
Y
R
R
P
S
S
S
S
Y
T
G
K
S
P
600
601
L
S
R
Y
N
M
S
Y
N
H
N
N
N
S
S
I
N
G
Y
A
R
R
G
S
T
T
T
V
Q
H
S
P
G
A
Y
I
P
P
N
A
R
N
H
H
V
S
P
T
N
Q
F
L
R
V
P
Q
S
T
A
P
660
661
D
I
S
T
V
L
G
G
K
P
S
Y
Q
E
H
Y
T
Q
D
S
M
D
S
E
G
D
H
D
S
D
D
V
L
F
T
L
E
E
G
D
H
D
F
V
N
G
M
D
N
L
S
I
N
D
H
L
P
H
T
T
720
721
V
G
S
H
N
E
V
F
V
H
A
S
T
N
H
N
N
N
G
N
N
N
H
I
D
T
N
S
T
T
N
Q
Y
H
R
Q
Y
I
P
P
P
L
T
T
S
L
H
I
N
N
N
N
N
E
S
N
E
L
P
D
780
781
L
L
K
S
P
A
S
S
E
A
H
L
N
L
S
S
G
P
I
D
P
I
L
T
G
N
I
G
N
R
Y
S
H
S
S
D
S
K
E
L
E
Q
E
R
R
L
S
M
E
Q
K
F
K
N
G
V
Y
V
P
P
840
841
H
H
R
K
S
F
N
L
G
T
Q
V
P
P
M
N
M
K
T
S
N
E
A
T
L
S
V
S
H
N
S
V
N
F
G
G
S
Y
N
S
R
R
S
S
A
N
E
S
N
P
L
H
M
N
K
A
L
E
K
L
900
901
S
S
S
P
G
A
K
S
S
F
V
G
F
P
K
P
L
L
P
R
N
H
S
S
T
T
I
A
L
Q
N
E
D
V
F
A
D
S
N
N
D
A
I
I
F
E
D
E
E
Y
E
G
E
S
D
K
M
A
H
G
960
961
K
M
E
G
G
D
N
E
S
S
S
T
S
P
D
E
R
Q
I
F
G
P
Y
E
I
Y
A
Q
T
F
A
G
S
T
H
D
K
K
L
G
A
G
R
K
T
S
I
Q
D
E
M
V
G
S
L
E
Q
Y
K
N
1020
1021
N
W
L
I
L
Q
Q
Q
D
1029
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0705
Peptide:
NFNNGN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P38691
UniProt Name:
KSP1_YEAST
Protein Name:
Serine/threonine-protein kinase KSP1
Position:
569-574
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.29
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-79.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.82
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0706 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0706
Peptide:
NFNYNN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
103-108
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
0.2
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-40.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0707 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-0707
Peptide:
NFVNYS
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q9NYQ7
UniProt Name:
CELR3_HUMAN
Protein Name:
Cadherin EGF LAG seven-pass G-type receptor 3
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.39
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.7
Area of the profile Above Threshold (AGGRESCAN):
1.07
Best Energy Score (PASTA 2.0):
-3.31
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0708 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0708
Peptide:
NGAAVD
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
122-127
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-36.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0709 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0709
Peptide:
NGADVG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
77-82
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
33.33
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-59.8
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.32
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0710 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0710
Peptide:
NGERIE
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
62-67
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
16.67
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-81.1
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.07
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0711 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
L
Q
Q
F
T
L
L
F
L
Y
L
S
I
A
S
A
K
T
I
T
G
V
F
D
S
F
N
S
L
T
W
S
N
A
A
N
Y
A
F
K
G
P
G
Y
P
T
W
N
A
V
L
G
W
S
L
D
G
T
S
60
61
A
N
P
G
D
T
F
T
L
N
M
P
C
V
F
K
Y
T
T
S
Q
T
S
V
D
L
T
A
D
G
V
K
Y
A
T
C
Q
F
Y
S
G
E
E
F
T
T
F
S
T
L
T
C
T
V
N
D
A
L
K
S
120
121
S
I
K
A
F
G
T
V
T
L
P
I
A
F
N
V
G
G
T
G
S
S
T
D
L
E
D
S
K
C
F
T
A
G
T
N
T
V
T
F
N
D
G
D
K
D
I
S
I
D
V
E
F
E
K
S
T
V
D
P
180
181
S
G
Y
L
Y
A
S
R
V
M
P
S
L
N
K
V
T
T
L
F
V
A
P
Q
C
E
N
G
Y
T
S
G
T
M
G
F
S
S
S
N
G
D
V
A
I
D
C
S
N
I
H
I
G
I
T
K
G
L
N
D
240
241
W
N
Y
P
V
S
S
E
S
F
S
Y
T
K
T
C
T
S
N
G
I
Q
I
K
Y
Q
N
V
P
A
G
Y
R
P
F
I
D
A
Y
I
S
A
T
D
V
N
Q
Y
T
L
A
Y
T
N
D
Y
T
C
A
G
300
301
S
R
S
Q
S
K
P
F
T
L
R
W
T
G
Y
K
N
S
D
A
G
S
N
G
I
V
I
V
A
T
T
R
T
V
T
D
S
T
T
A
V
T
T
L
P
F
N
P
S
V
D
K
T
K
T
I
E
I
L
Q
360
361
P
I
P
T
T
T
I
T
T
S
Y
V
G
V
T
T
S
Y
S
T
K
T
A
P
I
G
E
T
A
T
V
I
V
D
V
P
Y
H
T
T
T
T
V
T
S
E
W
T
G
T
I
T
T
T
T
T
R
T
N
P
420
421
T
D
S
I
D
T
V
V
V
Q
V
P
S
P
N
P
T
V
S
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
480
481
S
Q
S
F
A
T
T
T
T
V
T
A
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
540
541
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
I
T
A
600
601
P
P
G
E
T
D
T
V
I
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
660
661
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
L
I
R
E
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
720
721
P
P
N
H
T
V
T
T
T
E
Y
W
S
Q
S
Y
A
T
T
T
T
V
T
A
P
P
G
G
T
D
T
V
I
I
R
E
P
P
N
Y
T
V
T
T
T
E
Y
W
S
Q
S
F
A
T
T
T
T
V
T
A
780
781
P
P
G
G
T
D
T
V
I
I
Y
E
S
M
S
S
S
K
I
S
T
S
S
N
D
I
T
S
I
I
P
S
F
S
R
P
H
Y
V
N
S
T
T
S
D
L
S
T
F
E
S
S
S
M
N
T
P
T
S
I
840
841
S
S
D
G
M
L
L
S
S
T
T
L
V
T
E
S
E
T
T
T
E
S
I
C
S
D
G
K
E
C
S
R
L
S
S
S
S
G
I
V
T
N
P
D
S
N
E
S
S
I
V
T
S
T
V
P
T
A
S
T
900
901
M
S
D
S
L
S
S
T
D
G
I
S
A
T
S
S
D
N
V
S
K
S
G
V
S
V
T
T
E
T
S
V
T
T
I
Q
T
T
P
N
P
L
S
S
S
V
T
S
L
T
Q
L
S
S
I
P
S
V
S
E
960
961
S
E
S
K
V
T
F
T
S
N
G
D
N
Q
S
G
T
H
D
S
Q
S
T
S
T
E
I
E
I
V
T
T
S
S
T
K
V
L
P
P
V
V
S
S
N
T
D
L
T
S
E
P
T
N
T
R
E
Q
P
T
1020
1021
T
L
S
T
T
S
N
S
I
T
E
D
I
T
T
S
Q
P
T
G
D
N
G
D
N
T
S
S
T
N
P
V
P
T
V
A
T
S
T
L
A
S
A
S
E
E
D
N
K
S
G
S
H
E
S
A
S
T
S
L
1080
1081
K
P
S
M
G
E
N
S
G
L
T
T
S
T
E
I
E
A
T
T
T
S
P
T
E
A
P
S
P
A
V
S
S
G
T
D
V
T
T
E
P
T
D
T
R
E
Q
P
T
T
L
S
T
T
S
K
T
N
S
E
1140
1141
S
V
A
T
T
Q
A
T
N
E
N
G
G
K
S
P
S
T
D
L
T
S
S
L
T
T
G
T
S
A
S
T
S
A
N
S
E
L
V
T
S
G
S
V
T
G
G
A
V
A
S
A
S
N
D
Q
S
H
S
T
1200
1201
S
V
T
N
S
N
S
I
V
S
N
T
P
Q
T
T
L
S
Q
Q
V
T
S
S
S
P
S
T
N
T
F
I
A
S
T
Y
D
G
S
G
S
I
I
Q
H
S
T
W
L
Y
G
L
I
T
L
L
S
L
F
I
1260
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0711
Peptide:
NGIVIV
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q5A8T4
UniProt Name:
ALS1_CANAL
Protein Name:
Agglutinin-like protein 1 (Adhesin 1)
Position:
323-328
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
66.67
NuAPRpred:
1.05
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
70.3
Area of the profile Above Threshold (AGGRESCAN):
4.35
Best Energy Score (PASTA 2.0):
-7.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0712 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0712
Peptide:
NGKSNF
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
37-42
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
16.67
NuAPRpred:
-0.5
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-62.5
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0713 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
N
K
R
L
Y
N
G
N
L
S
N
I
P
E
V
I
D
P
G
I
T
I
P
I
Y
E
E
D
I
R
N
D
T
R
M
N
T
N
A
R
S
V
R
V
S
D
K
R
G
R
S
S
S
T
S
P
Q
K
60
61
I
G
S
Y
R
T
R
A
G
R
F
S
D
T
L
T
N
L
L
P
S
I
S
A
K
L
H
H
S
K
K
S
T
P
V
V
V
V
P
P
T
S
S
T
P
D
S
L
N
S
T
T
Y
A
P
R
V
S
S
D
120
121
S
F
T
V
A
T
P
L
S
L
Q
S
T
T
T
R
T
R
T
R
N
N
T
V
S
S
Q
I
T
A
S
S
S
L
T
T
D
V
G
N
A
T
S
A
N
I
W
S
A
N
A
E
S
N
T
S
S
S
P
L
180
181
F
D
Y
P
L
A
T
S
Y
F
E
P
L
T
R
F
K
S
T
D
N
Y
T
L
P
Q
T
A
Q
L
N
S
F
L
E
K
N
G
N
P
N
I
W
S
S
A
G
N
S
N
T
D
H
L
N
T
P
I
V
N
240
241
R
Q
R
S
Q
S
Q
S
T
T
N
R
V
Y
T
D
A
P
Y
Y
Q
Q
P
A
Q
N
Y
Q
V
Q
V
P
P
R
V
P
K
S
T
S
I
S
P
V
I
L
D
D
V
D
P
A
S
I
N
W
I
T
A
N
300
301
Q
K
V
P
L
V
N
Q
I
S
A
L
L
P
T
N
T
I
S
I
S
N
V
F
P
L
Q
P
T
Q
Q
H
Q
Q
N
A
V
N
L
T
S
T
S
L
A
T
L
C
S
Q
Y
G
K
V
L
S
A
R
T
L
360
361
R
G
L
N
M
A
L
V
E
F
S
T
V
E
S
A
I
C
A
L
E
A
L
Q
G
K
E
L
S
K
V
G
A
P
S
T
V
S
F
A
R
V
L
P
M
Y
E
Q
P
L
N
V
N
G
F
N
N
T
P
K
420
421
Q
P
L
L
Q
E
Q
L
N
H
G
V
L
N
Y
Q
L
Q
Q
S
L
Q
Q
P
E
L
Q
Q
Q
P
T
S
F
N
Q
P
N
L
T
Y
C
N
P
T
Q
N
L
S
H
L
Q
L
S
S
N
E
N
E
P
Y
480
481
P
F
P
L
P
P
P
S
L
S
D
S
K
K
D
I
L
H
T
I
S
S
F
K
L
E
Y
D
H
L
E
L
N
H
L
L
Q
N
A
L
K
N
K
G
V
S
D
T
N
Y
F
G
P
L
P
E
H
N
S
K
540
541
V
P
K
R
K
D
T
F
D
A
P
K
L
R
E
L
R
K
Q
F
D
S
N
S
L
S
T
I
E
M
E
Q
L
A
I
V
M
L
D
Q
L
P
E
L
S
S
D
Y
L
G
N
T
V
I
Q
K
L
F
E
N
600
601
S
S
N
I
I
R
D
I
M
L
R
K
C
N
K
Y
L
T
S
M
G
V
H
K
N
G
T
W
V
C
Q
K
I
I
K
M
A
N
T
P
R
Q
I
N
L
V
T
S
G
V
S
D
Y
C
T
P
L
F
N
D
660
661
Q
F
G
N
Y
V
I
Q
G
I
L
K
F
G
F
P
W
N
S
F
I
F
E
S
V
L
S
H
F
W
T
I
V
Q
N
R
Y
G
S
R
A
V
R
A
C
L
E
A
D
S
I
I
T
Q
C
Q
L
L
T
I
720
721
T
S
L
I
I
V
L
S
P
Y
L
A
T
D
T
N
G
T
L
L
I
T
W
L
L
D
T
C
T
L
P
N
K
N
L
I
L
C
D
K
L
V
N
K
N
L
V
K
L
C
C
H
K
L
G
S
L
T
V
L
780
781
K
I
L
N
L
R
G
G
E
E
E
A
L
S
K
N
K
I
I
H
A
I
F
D
G
P
I
S
S
D
S
I
L
F
Q
I
L
D
E
G
N
Y
G
P
T
F
I
Y
K
V
L
T
S
R
I
L
D
N
S
V
840
841
R
D
E
A
I
T
K
I
R
Q
L
I
L
N
S
N
I
N
L
Q
S
R
Q
L
L
E
E
V
G
L
S
S
A
G
I
S
P
K
Q
S
S
K
N
H
R
K
Q
H
P
Q
G
F
H
S
P
G
R
A
R
G
900
901
V
S
V
S
S
V
R
S
S
N
S
R
H
N
S
V
I
Q
M
N
N
A
G
P
T
P
A
L
N
F
N
P
A
P
M
S
E
I
N
S
Y
F
N
N
Q
Q
V
V
Y
S
G
N
Q
N
Q
N
Q
N
G
N
960
961
S
N
G
L
D
E
L
N
S
Q
F
D
S
F
R
I
A
N
G
T
N
L
S
L
P
I
V
N
L
P
N
V
S
N
N
N
N
N
Y
N
N
S
G
Y
S
S
Q
M
N
P
L
S
R
S
V
S
H
N
N
N
1020
1021
N
N
T
N
N
Y
N
N
N
D
N
D
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
S
N
N
S
N
N
N
N
N
N
D
T
S
L
Y
R
Y
R
S
Y
G
Y
1075
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0713
Peptide:
NGNLSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q12221
UniProt Name:
PUF2_YEAST
Protein Name:
mRNA-binding protein PUF2 (Pumilio homology domain family member 2)
Position:
8-13
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-53.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.05
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0714 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
F
F
N
L
N
N
N
N
N
N
N
N
T
T
T
T
T
T
T
T
N
N
N
N
T
N
N
N
N
T
N
N
N
N
N
P
A
N
N
T
N
N
N
N
S
T
G
H
S
S
N
T
N
N
N
T
N
N
60
61
N
N
T
N
T
G
A
S
G
V
D
D
F
Q
N
F
F
D
P
K
P
F
D
Q
N
L
D
S
N
N
N
N
S
N
S
N
N
N
D
N
N
N
S
N
T
V
A
S
S
T
N
F
T
S
P
T
A
V
V
N
120
121
N
A
A
P
A
N
V
T
G
G
K
A
A
N
F
I
Q
N
Q
S
P
Q
F
N
S
P
Y
D
S
N
N
S
N
T
N
L
N
S
L
S
P
Q
A
I
L
A
K
N
S
I
I
D
S
S
N
L
P
L
Q
A
180
181
Q
Q
Q
L
Y
G
G
N
N
N
N
N
S
T
G
I
A
N
D
N
V
I
T
P
H
F
I
T
N
V
Q
S
I
S
Q
N
S
S
S
S
T
P
N
T
N
S
N
S
T
P
N
A
N
Q
Q
F
L
P
F
N
240
241
N
S
A
S
N
N
G
N
L
T
S
N
Q
L
I
S
N
Y
A
A
S
N
S
M
D
R
S
S
S
A
S
N
E
F
V
P
N
T
S
D
N
N
N
N
S
N
N
H
N
M
R
N
N
S
N
N
K
T
S
N
300
301
N
N
N
V
T
A
V
P
A
A
T
P
A
N
T
N
N
S
T
S
N
A
N
T
V
F
S
E
R
A
A
M
F
A
A
L
Q
Q
K
Q
Q
Q
R
F
Q
A
L
Q
Q
Q
Q
Q
Q
Q
Q
N
Q
Q
Q
Q
360
361
N
Q
Q
P
Q
Q
Q
Q
Q
Q
Q
Q
N
P
K
F
L
Q
S
Q
R
Q
Q
Q
Q
R
S
I
L
Q
S
L
N
P
A
L
Q
E
K
I
S
T
E
L
N
N
K
Q
Y
E
L
F
M
K
S
L
I
E
N
C
420
421
K
K
R
N
M
P
L
Q
S
I
P
E
I
G
N
R
K
I
N
L
F
Y
L
Y
M
L
V
Q
K
F
G
G
A
D
Q
V
T
R
T
Q
Q
W
S
M
V
A
Q
R
L
Q
I
S
D
Y
Q
Q
L
E
S
I
480
481
Y
F
R
I
L
L
P
Y
E
R
H
M
I
S
Q
E
G
I
K
E
T
Q
A
K
R
I
F
L
Q
Q
F
L
Q
E
L
L
K
K
V
Q
Q
Q
Q
Q
A
A
A
L
A
N
A
N
N
N
I
N
S
A
S
S
540
541
A
P
T
P
A
A
P
G
A
S
V
P
A
T
A
A
P
G
T
E
A
G
I
V
P
V
S
A
N
T
P
K
S
L
N
S
N
I
N
I
N
V
N
N
N
N
I
G
Q
Q
Q
V
K
K
P
R
K
Q
R
V
600
601
K
K
K
T
K
K
E
L
E
L
E
R
K
E
R
E
D
F
Q
K
R
Q
Q
K
L
L
E
D
Q
Q
R
Q
Q
K
L
L
L
E
T
K
L
R
Q
Q
Y
E
I
E
L
K
K
L
P
K
V
Y
K
R
S
I
660
661
V
R
N
Y
K
P
L
I
N
R
L
K
H
Y
N
G
Y
D
I
N
Y
I
S
K
I
G
E
K
I
D
S
N
K
P
I
F
L
F
A
P
E
L
G
A
I
N
L
H
A
L
S
M
S
L
Q
S
K
N
L
G
720
721
E
I
N
T
A
L
N
T
L
L
V
T
S
A
D
S
N
L
K
I
S
L
V
K
Y
P
E
L
L
D
S
L
A
I
L
G
M
N
L
L
S
N
L
S
Q
N
V
V
P
Y
H
R
N
T
S
D
Y
Y
Y
E
780
781
D
A
G
S
N
Q
Y
Y
V
T
Q
H
D
K
M
V
D
K
I
F
E
K
V
N
N
N
A
T
L
T
P
N
D
S
N
D
E
K
V
T
I
L
V
D
S
L
T
G
N
Q
L
P
T
P
T
P
T
E
M
E
840
841
P
D
L
D
T
E
C
F
I
S
M
Q
S
T
S
P
A
V
K
Q
W
D
L
L
P
E
P
I
R
F
L
P
N
Q
F
P
L
K
I
H
R
T
P
Y
L
T
S
L
K
K
I
K
D
E
I
D
D
P
F
T
900
901
K
I
N
T
R
G
A
E
D
P
K
V
L
I
N
D
Q
L
S
T
I
S
M
I
L
R
N
I
S
F
S
D
N
N
S
R
I
M
S
R
N
F
Y
L
K
R
F
I
S
D
L
L
W
L
V
L
I
H
P
E
960
961
N
F
T
C
N
R
K
I
L
N
F
K
K
D
L
V
I
V
L
S
N
I
S
H
L
L
E
I
A
S
S
I
D
C
L
L
I
L
I
L
V
I
S
F
G
Q
P
K
L
N
P
M
A
S
S
S
S
F
G
S
1020
1021
E
S
L
T
F
N
E
F
Q
L
Q
W
G
K
Y
Q
T
F
G
V
D
I
L
A
K
L
F
S
L
E
K
P
N
L
N
Y
F
K
S
I
L
L
N
K
N
T
G
N
N
L
Y
D
R
N
S
N
N
N
H
K
1080
1081
D
K
K
L
L
R
R
L
L
N
L
Y
N
D
N
N
K
N
N
N
N
R
H
N
L
L
N
D
V
V
S
F
L
F
S
A
I
P
L
Q
Q
V
L
S
Q
S
A
D
P
S
L
L
I
D
Q
F
S
P
V
I
1140
1141
S
Q
S
L
T
S
I
L
V
I
V
Q
K
I
L
P
L
S
N
E
V
F
E
I
S
E
N
N
S
D
S
N
S
N
N
N
G
N
K
D
S
S
F
N
F
N
K
N
L
P
F
V
W
L
S
S
E
E
N
I
1200
1201
G
S
G
L
L
K
L
S
E
I
I
L
N
I
N
N
S
T
S
K
N
T
L
L
Q
Q
Q
N
Y
S
K
V
L
L
P
S
I
N
I
S
C
V
Q
L
I
K
C
L
V
E
K
S
I
C
F
E
N
C
L
N
1260
1261
N
D
P
E
I
L
K
K
I
A
S
I
P
N
L
F
P
T
D
L
E
I
F
Q
L
F
T
N
P
S
V
D
I
Q
I
I
N
Q
Y
Q
L
L
Y
N
L
K
N
D
I
L
T
N
L
E
1314
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0714
Peptide:
NGNLTS
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P09547
UniProt Name:
SWI1_YEAST
Protein Name:
SWI/SNF chromatin-remodeling complex subunit SWI1
Position:
246-251
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
16.67
NuAPRpred:
-0.47
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-41.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-0.15
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0715 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
H
Y
V
V
L
E
L
Q
V
A
H
L
P
D
T
P
K
D
Q
C
R
I
A
N
I
A
F
Q
I
V
N
A
E
T
L
V
C
H
Y
G
T
N
S
L
P
S
I
E
V
N
G
T
T
K
S
L
E
S
A
60
61
M
V
Q
L
D
K
D
I
H
D
V
I
G
N
D
D
F
V
L
V
S
L
Y
S
T
W
H
I
R
V
T
L
P
R
Q
A
R
D
D
G
F
I
L
T
S
Y
L
Q
H
P
K
V
F
D
L
W
K
E
F
D
120
121
R
W
C
V
N
H
P
E
I
L
G
Q
K
K
A
I
S
N
N
N
C
N
T
K
S
I
S
I
N
A
A
K
N
T
K
D
L
D
E
I
V
R
I
L
E
V
S
I
P
T
E
E
A
G
S
V
P
E
I
Y
180
181
S
L
L
K
R
T
T
D
I
L
I
Q
L
H
K
K
C
T
S
P
E
D
M
E
S
V
L
T
K
P
Y
D
S
H
T
D
I
R
A
F
L
Q
E
K
S
K
I
L
Y
M
N
N
L
P
P
D
T
T
Q
S
240
241
E
L
E
S
W
F
T
Q
Y
G
V
R
P
V
G
F
W
T
V
K
N
I
V
E
D
T
S
N
V
N
N
N
W
S
L
N
N
S
P
Y
V
E
D
Q
D
S
I
S
G
F
V
V
F
Q
T
H
E
E
A
T
300
301
E
V
L
A
L
N
G
R
S
I
L
S
N
L
A
N
T
K
Q
P
R
V
V
E
H
V
L
E
L
Q
P
S
S
T
G
V
L
D
K
A
Q
E
I
L
S
P
F
P
Q
S
K
N
K
P
R
P
G
D
W
N
360
361
C
P
S
C
G
F
S
N
F
Q
R
R
T
A
C
F
R
C
S
F
P
A
P
S
N
S
Q
I
H
T
A
N
S
N
N
N
V
N
S
S
R
N
N
L
N
N
R
V
N
S
G
S
S
S
N
I
S
N
T
A
420
421
A
N
H
P
Y
G
A
P
E
F
N
M
I
A
N
N
T
P
A
A
L
T
Y
N
R
A
H
F
P
A
I
T
P
L
S
R
Q
N
S
L
N
M
A
P
S
N
S
G
S
P
I
I
I
A
D
H
F
S
G
N
480
481
N
N
I
A
P
N
Y
R
Y
N
N
N
I
N
N
N
N
N
N
I
N
N
M
T
N
N
R
Y
N
I
N
N
N
I
N
G
N
G
N
G
N
G
N
N
S
N
N
N
N
N
H
N
N
N
H
N
N
N
H
H
540
541
N
G
S
I
N
S
N
S
N
T
N
N
N
N
N
N
N
N
G
N
N
S
N
N
C
N
S
N
I
G
M
G
G
C
G
S
N
M
P
F
R
A
G
D
W
K
C
S
T
C
T
Y
H
N
F
A
K
N
V
V
600
601
C
L
R
C
G
G
P
K
S
I
S
G
D
A
S
E
T
N
H
Y
I
D
S
S
T
F
G
P
A
S
R
T
P
S
N
N
N
I
S
V
N
T
N
G
G
S
N
A
G
R
T
D
G
N
D
N
K
G
R
D
660
661
I
S
L
M
E
F
M
S
P
P
L
S
M
A
T
K
S
M
K
E
G
D
G
N
G
S
S
F
N
E
F
K
S
D
K
A
N
V
N
F
S
N
V
G
D
N
S
A
F
G
N
G
F
N
S
S
I
R
W
719
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0715
Peptide:
NGNNSN
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P32770
UniProt Name:
NRP1_YEAST
Protein Name:
Asparagine-rich protein (Protein ARP)
Position:
521-526
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.51
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-107.2
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.73
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0716 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
D
T
D
K
L
I
S
E
A
E
S
H
F
S
Q
G
N
H
A
E
A
V
A
K
L
T
S
A
A
Q
S
N
P
N
D
E
Q
M
S
T
I
E
S
L
I
Q
K
I
A
G
Y
V
M
D
N
R
S
G
G
60
61
S
D
A
S
Q
D
R
A
A
G
G
G
S
S
F
M
N
T
L
M
A
D
S
K
G
S
S
Q
T
Q
L
G
K
L
A
L
L
A
T
V
M
T
H
S
S
N
K
G
S
S
N
R
G
F
D
V
G
T
V
M
120
121
S
M
L
S
G
S
G
G
G
S
Q
S
M
G
A
S
G
L
A
A
L
A
S
Q
F
F
K
S
G
N
N
S
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
Q
G
S
F
T
A
L
A
S
L
180
181
A
S
S
F
M
N
S
N
N
N
N
Q
Q
G
Q
N
Q
S
S
G
G
S
S
F
G
A
L
A
S
M
A
S
S
F
M
H
S
N
N
N
Q
N
S
N
N
S
Q
Q
G
Y
N
Q
S
Y
Q
N
G
N
Q
N
240
241
S
Q
G
Y
N
N
Q
Q
Y
Q
G
G
N
G
G
Y
Q
Q
Q
Q
G
Q
S
G
G
A
F
S
S
L
A
S
M
A
Q
S
Y
L
G
G
G
Q
T
Q
S
N
Q
Q
Q
Y
N
Q
Q
G
Q
N
N
Q
Q
Q
300
301
Y
Q
Q
Q
G
Q
N
Y
Q
H
Q
Q
Q
G
Q
Q
Q
Q
Q
G
H
S
S
S
F
S
A
L
A
S
M
A
S
S
Y
L
G
N
N
S
N
S
N
S
S
Y
G
G
Q
Q
Q
A
N
E
Y
G
R
P
Q
Q
360
361
N
G
Q
Q
Q
S
N
E
Y
G
R
P
Q
Y
G
G
N
Q
N
S
N
G
Q
H
E
S
F
N
F
S
G
N
F
S
Q
Q
N
N
N
G
N
Q
N
R
Y
405
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0716
Peptide:
NGNQNR
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P25367
UniProt Name:
RNQ1_YEAST
Protein Name:
[PIN+] prion protein RNQ1
Position:
399-404
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
0.0
NuAPRpred:
-0.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-118.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.18
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0717 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0717
Peptide:
NGNQQQ
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
19-24
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.48
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-117.6
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.45
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0718 Classification: Amyloid
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Peptide details
Entry:
P-0718
Peptide:
NHFCIQ
Length:
6
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q99467
UniProt Name:
CD180_HUMAN
Protein Name:
CD180 antigen (Lymphocyte antigen 64)
Position:
Literature
PMID:
23815227
Reference:
BMC Bioinformatics. 2013;14 Suppl 8:S6.
source:
CPAD, Waltz-DB 2.0
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
50.0
NuAPRpred:
0.87
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.3
Area of the profile Above Threshold (AGGRESCAN):
1.58
Best Energy Score (PASTA 2.0):
-2.87
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-0719 Classification: Non-amyloid
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Sequence
1
M
K
L
L
K
V
A
A
I
A
A
I
V
F
S
G
S
A
L
A
G
V
V
P
Q
Y
G
G
G
G
N
H
G
G
G
G
N
N
S
G
P
N
S
E
L
N
I
Y
Q
Y
G
G
G
N
S
A
L
A
L
Q
60
61
T
D
A
R
N
S
D
L
T
I
T
Q
H
G
G
G
N
G
A
D
V
G
Q
G
S
D
D
S
S
I
D
L
T
Q
R
G
F
G
N
S
A
T
L
D
Q
W
N
G
K
N
S
E
M
T
V
K
Q
F
G
G
120
121
G
N
G
A
A
V
D
Q
T
A
S
N
S
S
V
N
V
T
Q
V
G
F
G
N
N
A
T
A
H
Q
Y
151
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0719
Peptide:
NHGGGG
Length:
6
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P28307
UniProt Name:
CSGA_ECOLI
Protein Name:
Major curlin subunit
Position:
31-36
Literature
PMID:
SwitchLab
Reference:
Switch Lab
source:
Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-0.44
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-78.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
2.77
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-0720 Classification: Amyloid
CSV
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Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-0720
Peptide:
NHVTLS
Length:
6
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
103-108
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, Waltz-DB 2.0, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
33.33
NuAPRpred:
-0.08
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.7
Area of the profile Above Threshold (AGGRESCAN):
1.05
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
