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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
Download
Contact Us
Links
APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1681 to 1710 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1681
YQQYNPQGGY
10
Non-amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
AmyLoad
P-1682
YQRGSSMVLF
10
Non-amyloid
Major prion protein (PrP)
P04156
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1683
YRGISLANWM
10
Non-amyloid
Lysozyme C
P61626
No
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
AmyLoad
P-1684
YSGYQQGGYQ
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1685
YSQNGNQQQG
10
Amyloid
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
P05453
No
Nat Methods. 2010 Mar;7(3):237-42.
20154676
CPAD, AmyLoad
P-1686
AIIGLMVGGVV
11
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
P-1687
CATQRLANFLV
11
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Proc Natl Acad Sci U S A. 1990 Jul;87(13):5036-40.
2195544
CPAD
P-1688
CPLMVKVLDAV
11
Amyloid
Transthyretin (ATTR) (Prealbumin) (TBPA)
P02766
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1689
FSMLVAAIQSA
11
Amyloid
FEBS Lett. 2007 Jan 23;581(2):241-7.
17207483
CPAD
P-1690
GAVVTGVTAVA
11
Amyloid
Alpha-synuclein
P37840
No
J Biol Chem. 2001 Jan 26;276(4):2380-6.
11060312
CPAD
P-1691
GYANNFLFKQG
11
Amyloid
50S ribosomal protein L9 (BL17)
P02417
No
J Mol Biol. 1999 Mar 26;287(2):395-407.
10080901
CPAD, AmyLoad
P-1692
HHQKLVFFAED
11
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1693
ILLISFLFIFL
11
Amyloid
Major prion protein (PrP)
P04156
[del]248F
Nat Biotechnol. 2004 Oct;22(10):1302-6.
15361882
CPAD
P-1694
KRNNFKSAEDS
11
Non-amyloid
Pancreatic trypsin inhibitor (Aprotinin)
P00974
C86S
J Mol Biol. 1993 Dec 5;234(3):861-78.
7504737
AmyLoad
P-1695
MKVIFLKDVKG
11
Amyloid
50S ribosomal protein L9
B7IS13
No
J Mol Biol. 1999 Mar 26;287(2):395-407.
10080901
CPAD, AmyLoad
P-1696
MSTYTGIFTDQ
11
Amyloid
Apolipoprotein C-II (ApoC-II)
P02655
No
J Mol Biol. 2007 Mar 9;366(5):1639-51.
17217959
CPAD
P-1697
RTVKKNIIEEN
11
Amyloid
Biochemistry. 2001 Mar 27;40(12):3449-57.
11297410
CPAD
P-1698
SFFSFLGEAFD
11
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1699
SFNNGDCFILD
11
Amyloid
Gelsolin (AGEL)
P06396
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1700
SFNNGNCFILD
11
Amyloid
Gelsolin (AGEL)
P06396
D214N
J Clin Pathol. 2000 Feb;53(2):95-9.
10767822
CPAD
P-1701
SFNNGYCFILD
11
Amyloid
Gelsolin (AGEL)
P06396
D214Y
J Clin Pathol. 2000 Feb;53(2):95-9.
10767822
CPAD
P-1702
VALRIQNVRFS
11
Amyloid
Myelin-oligodendrocyte glycoprotein
Q63345
No
PLoS Biol. 2008 Aug 5;6(8):e195.
18684013
CPAD
P-1703
VTGVTAVQKTV
11
Amyloid
Alpha-synuclein
P37840
[del]78A
J Biol Chem. 2001 Jan 26;276(4):2380-6.
11060312
AmyLoad
P-1704
VVLDDKDYFLF
11
Amyloid
heat shock protein, mitochondrial (Hsp10)
P26772
No
J Mol Biol. 2008 Apr 11;377(5):1593-606.
18329043
CPAD
P-1705
YTIAALLSPYS
11
Amyloid
Transthyretin (ATTR) (Prealbumin) (TBPA)
P02766
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1706
YTSPHQGAGMV
11
Non-amyloid
Plastocyanin
P00287
C84T
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1707
AASIKVAVSADR
12
Amyloid
Laminin subunit alpha-1 (Laminin A chain)
P25391
No
Biochemistry. 2007 Apr 3;46(13):3966-74.
17348688
CPAD
P-1708
DISTKYFQMSLE
12
Amyloid
Laminin subunit beta-1 (Laminin B1 chain)
P02469
Biochemistry. 2007 Apr 3;46(13):3966-74.
17348688
CPAD
P-1709
FHPSDIEVDLLK
12
Non-amyloid
Beta-2-microglobulin
P61769
No
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
12488093
AmyLoad
P-1710
GAVVYSGSLYFQ
12
Amyloid
Myocilin
Q99972
No
J Mol Biol. 2014 Feb 20;426(4):921-35
24333014
CPAD
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Entry: P-1681 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1681
Peptide:
YQQYNPQGGY
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
79-88
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
40.0
NuAPRpred:
-2.96
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-45.9
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
-1.09
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1682 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1682
Peptide:
YQRGSSMVLF
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
226-235
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-1.49
Tango:
2.39
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.0
Area of the profile Above Threshold (AGGRESCAN):
3.92
Best Energy Score (PASTA 2.0):
-3.83
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1683 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
A
L
I
V
L
G
L
V
L
L
S
V
T
V
Q
G
K
V
F
E
R
C
E
L
A
R
T
L
K
R
L
G
M
D
G
Y
R
G
I
S
L
A
N
W
M
C
L
A
K
W
E
S
G
Y
N
T
R
A
60
61
T
N
Y
N
A
G
D
R
S
T
D
Y
G
I
F
Q
I
N
S
R
Y
W
C
N
D
G
K
T
P
G
A
V
N
A
C
H
L
S
C
S
A
L
L
Q
D
N
I
A
D
A
V
A
C
A
K
R
V
V
R
D
120
121
P
Q
G
I
R
A
W
V
A
W
R
N
R
C
Q
N
R
D
V
R
Q
Y
V
Q
G
C
G
V
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1683
Peptide:
YRGISLANWM
Length:
10
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61626
UniProt Name:
LYSC_HUMAN
Protein Name:
Lysozyme C
Position:
38-47
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
60.0
NuAPRpred:
0.17
Tango:
2.6
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.9
Area of the profile Above Threshold (AGGRESCAN):
1.86
Best Energy Score (PASTA 2.0):
-2.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1684 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1684
Peptide:
YSGYQQGGYQ
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
52-61
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
30.0
NuAPRpred:
-2.25
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-32.2
Area of the profile Above Threshold (AGGRESCAN):
0.07
Best Energy Score (PASTA 2.0):
0.04
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1685 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
D
S
N
Q
G
N
N
Q
Q
N
Y
Q
Q
Y
S
Q
N
G
N
Q
Q
Q
G
N
N
R
Y
Q
G
Y
Q
A
Y
N
A
Q
A
Q
P
A
G
G
Y
Y
Q
N
Y
Q
G
Y
S
G
Y
Q
Q
G
G
Y
60
61
Q
Q
Y
N
P
D
A
G
Y
Q
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Y
N
P
Q
G
G
Y
Q
Q
Q
F
N
P
Q
G
G
R
G
N
Y
K
N
F
N
Y
N
N
N
L
Q
G
Y
Q
A
G
F
Q
P
Q
120
121
S
Q
G
M
S
L
N
D
F
Q
K
Q
Q
K
Q
A
A
P
K
P
K
K
T
L
K
L
V
S
S
S
G
I
K
L
A
N
A
T
K
K
V
G
T
K
P
A
E
S
D
K
K
E
E
E
K
S
A
E
T
K
180
181
E
P
T
K
E
P
T
K
V
E
E
P
V
K
K
E
E
K
P
V
Q
T
E
E
K
T
E
E
K
S
E
L
P
K
V
E
D
L
K
I
S
E
S
T
H
N
T
N
N
A
N
V
T
S
A
D
A
L
I
K
240
241
E
Q
E
E
E
V
D
D
E
V
V
N
D
M
F
G
G
K
D
H
V
S
L
I
F
M
G
H
V
D
A
G
K
S
T
M
G
G
N
L
L
Y
L
T
G
S
V
D
K
R
T
I
E
K
Y
E
R
E
A
K
300
301
D
A
G
R
Q
G
W
Y
L
S
W
V
M
D
T
N
K
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
F
E
T
E
K
R
R
Y
T
I
L
D
A
P
G
H
K
M
Y
V
S
E
M
I
G
G
A
S
360
361
Q
A
D
V
G
V
L
V
I
S
A
R
K
G
E
Y
E
T
G
F
E
R
G
G
Q
T
R
E
H
A
L
L
A
K
T
Q
G
V
N
K
M
V
V
V
V
N
K
M
D
D
P
T
V
N
W
S
K
E
R
Y
420
421
D
Q
C
V
S
N
V
S
N
F
L
R
A
I
G
Y
N
I
K
T
D
V
V
F
M
P
V
S
G
Y
S
G
A
N
L
K
D
H
V
D
P
K
E
C
P
W
Y
T
G
P
T
L
L
E
Y
L
D
T
M
N
480
481
H
V
D
R
H
I
N
A
P
F
M
L
P
I
A
A
K
M
K
D
L
G
T
I
V
E
G
K
I
E
S
G
H
I
K
K
G
Q
S
T
L
L
M
P
N
K
T
A
V
E
I
Q
N
I
Y
N
E
T
E
N
540
541
E
V
D
M
A
M
C
G
E
Q
V
K
L
R
I
K
G
V
E
E
E
D
I
S
P
G
F
V
L
T
S
P
K
N
P
I
K
S
V
T
K
F
V
A
Q
I
A
I
V
E
L
K
S
I
I
A
A
G
F
S
600
601
C
V
M
H
V
H
T
A
I
E
E
V
H
I
V
K
L
L
H
K
L
E
K
G
T
N
R
K
S
K
K
P
P
A
F
A
K
K
G
M
K
V
I
A
V
L
E
T
E
A
P
V
C
V
E
T
Y
Q
D
Y
660
661
P
Q
L
G
R
F
T
L
R
D
Q
G
T
T
I
A
I
G
K
I
V
K
I
A
E
685
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1685
Peptide:
YSQNGNQQQG
Length:
10
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05453
UniProt Name:
ERF3_YEAST
Protein Name:
Eukaryotic peptide chain release factor GTP-binding subunit (ERF-3)
Position:
16-25
Literature
PMID:
20154676
Reference:
Nat Methods. 2010 Mar;7(3):237-42.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
10.0
NuAPRpred:
-2.56
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-92.7
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.04
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1686 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1686
Peptide:
AIIGLMVGGVV
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
701-711
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
72.73
NuAPRpred:
3.7
Tango:
437.61
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
58.8
Area of the profile Above Threshold (AGGRESCAN):
6.85
Best Energy Score (PASTA 2.0):
-6.89
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1687 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1687
Peptide:
CATQRLANFLV
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
40-50
Literature
PMID:
2195544
Reference:
Proc Natl Acad Sci U S A. 1990 Jul;87(13):5036-40.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
63.64
NuAPRpred:
-1.45
Tango:
24.77
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.3
Area of the profile Above Threshold (AGGRESCAN):
2.46
Best Energy Score (PASTA 2.0):
-3.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1688 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
H
R
L
L
L
L
C
L
A
G
L
V
F
V
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
M
V
K
V
L
D
A
V
R
G
S
P
A
I
N
V
A
V
H
V
F
R
K
A
A
D
D
T
60
61
W
E
P
F
A
S
G
K
T
S
E
S
G
E
L
H
G
L
T
T
E
E
E
F
V
E
G
I
Y
K
V
E
I
D
T
K
S
Y
W
K
A
L
G
I
S
P
F
H
E
H
A
E
V
V
F
T
A
N
D
S
120
121
G
P
R
R
Y
T
I
A
A
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
P
K
E
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1688
Peptide:
CPLMVKVLDAV
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02766
UniProt Name:
TTHY_HUMAN
Protein Name:
Transthyretin (ATTR) (Prealbumin) (TBPA)
Position:
30-40
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
81.82
NuAPRpred:
0.38
Tango:
17.67
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
40.8
Area of the profile Above Threshold (AGGRESCAN):
4.61
Best Energy Score (PASTA 2.0):
-4.38
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1689 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1689
Peptide:
FSMLVAAIQSA
Length:
11
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
17207483
Reference:
FEBS Lett. 2007 Jan 23;581(2):241-7.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
72.73
NuAPRpred:
2.22
Tango:
264.45
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
41.1
Area of the profile Above Threshold (AGGRESCAN):
5.25
Best Energy Score (PASTA 2.0):
-4.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1690 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1690
Peptide:
GAVVTGVTAVA
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
68-78
Literature
PMID:
11060312
Reference:
J Biol Chem. 2001 Jan 26;276(4):2380-6.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
63.64
NuAPRpred:
1.57
Tango:
685.1
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.4
Area of the profile Above Threshold (AGGRESCAN):
4.33
Best Energy Score (PASTA 2.0):
-6.34
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1691 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
I
F
L
K
D
V
K
G
K
G
K
K
G
E
I
K
N
V
A
D
G
Y
A
N
N
F
L
F
K
Q
G
L
A
I
E
A
T
P
A
N
L
K
A
L
E
A
Q
K
Q
K
E
Q
R
Q
A
A
E
60
61
E
L
A
N
A
K
K
L
K
E
Q
L
E
K
L
T
V
T
I
P
A
K
A
G
E
G
G
R
L
F
G
S
I
T
S
K
Q
I
A
E
S
L
Q
A
Q
H
G
L
K
L
D
K
R
K
I
E
L
A
D
A
120
121
I
R
A
L
G
Y
T
N
V
P
V
K
L
H
P
E
V
T
A
T
L
K
V
H
V
T
E
Q
K
149
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1691
Peptide:
GYANNFLFKQG
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02417
UniProt Name:
RL9_GEOSE
Protein Name:
50S ribosomal protein L9 (BL17)
Position:
24-34
Literature
PMID:
10080901
Reference:
J Mol Biol. 1999 Mar 26;287(2):395-407.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
45.45
NuAPRpred:
1.54
Tango:
1.19
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.4
Area of the profile Above Threshold (AGGRESCAN):
1.89
Best Energy Score (PASTA 2.0):
-2.51
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1692 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1692
Peptide:
HHQKLVFFAED
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
684-694
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
45.45
NuAPRpred:
2.31
Tango:
359.09
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.8
Area of the profile Above Threshold (AGGRESCAN):
3.79
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1693 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1693
Peptide:
ILLISFLFIFL
Length:
11
Classification:
Amyloid
Mutation(s):
[del]248F
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
241-250
Literature
PMID:
15361882
Reference:
Nat Biotechnol. 2004 Oct;22(10):1302-6.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
90.91
NuAPRpred:
6.16
Tango:
903.57
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
124.3
Area of the profile Above Threshold (AGGRESCAN):
14.39
Best Energy Score (PASTA 2.0):
-10.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1694 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
M
S
R
L
C
L
S
V
A
L
L
V
L
L
G
T
L
A
A
S
T
P
G
C
D
T
S
N
Q
A
K
A
Q
R
P
D
F
C
L
E
P
P
Y
T
G
P
C
K
A
R
I
I
R
Y
F
Y
N
A
60
61
K
A
G
L
C
Q
T
F
V
Y
G
G
C
R
A
K
R
N
N
F
K
S
A
E
D
C
M
R
T
C
G
G
A
I
G
P
W
E
N
L
100
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1694
Peptide:
KRNNFKSAEDS
Length:
11
Classification:
Non-amyloid
Mutation(s):
C86S
Structure(s):
No structures
Protein Information
UniProt ID:
P00974
UniProt Name:
BPT1_BOVIN
Protein Name:
Pancreatic trypsin inhibitor (Aprotinin)
Position:
76-86
Literature
PMID:
7504737
Reference:
J Mol Biol. 1993 Dec 5;234(3):861-78.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
18.18
NuAPRpred:
-2.88
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-73.4
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1695 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
I
F
L
K
D
V
K
G
K
G
K
K
G
E
V
K
N
V
P
D
G
Y
A
N
N
F
L
L
K
Q
G
L
A
A
E
A
T
N
S
S
M
K
T
L
E
A
Q
K
R
K
E
E
K
D
A
A
A
60
61
E
V
E
N
A
K
E
L
K
E
T
L
E
K
L
T
V
E
V
K
A
K
S
G
E
G
G
R
L
F
G
S
I
T
S
K
Q
I
V
D
A
M
Q
K
S
H
K
I
K
L
D
K
R
K
F
E
M
D
D
A
120
121
I
R
A
L
G
Y
T
N
V
T
V
K
L
H
P
Q
V
T
A
T
V
K
V
H
V
S
E
Q
148
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1695
Peptide:
MKVIFLKDVKG
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
B7IS13
UniProt Name:
RL9_BACC2
Protein Name:
50S ribosomal protein L9
Position:
1-11
Literature
PMID:
10080901
Reference:
J Mol Biol. 1999 Mar 26;287(2):395-407.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
54.55
NuAPRpred:
1.37
Tango:
32.82
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.5
Area of the profile Above Threshold (AGGRESCAN):
5.14
Best Energy Score (PASTA 2.0):
-5.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1696 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
T
R
L
L
P
A
L
F
L
V
L
L
V
L
G
F
E
V
Q
G
T
Q
Q
P
Q
Q
D
E
M
P
S
P
T
F
L
T
Q
V
K
E
S
L
S
S
Y
W
E
S
A
K
T
A
A
Q
N
L
Y
E
60
61
K
T
Y
L
P
A
V
D
E
K
L
R
D
L
Y
S
K
S
T
A
A
M
S
T
Y
T
G
I
F
T
D
Q
V
L
S
V
L
K
G
E
E
101
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1696
Peptide:
MSTYTGIFTDQ
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02655
UniProt Name:
APOC2_HUMAN
Protein Name:
Apolipoprotein C-II (ApoC-II)
Position:
82-92
Literature
PMID:
17217959
Reference:
J Mol Biol. 2007 Mar 9;366(5):1639-51.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
36.36
NuAPRpred:
-0.61
Tango:
20.75
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.0
Area of the profile Above Threshold (AGGRESCAN):
2.54
Best Energy Score (PASTA 2.0):
-2.43
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1697 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1697
Peptide:
RTVKKNIIEEN
Length:
11
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
11297410
Reference:
Biochemistry. 2001 Mar 27;40(12):3449-57.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
27.27
NuAPRpred:
0.78
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-27.5
Area of the profile Above Threshold (AGGRESCAN):
0.21
Best Energy Score (PASTA 2.0):
-3.33
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1698 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1698
Peptide:
SFFSFLGEAFD
Length:
11
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
54.55
NuAPRpred:
1.54
Tango:
360.34
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
24.7
Area of the profile Above Threshold (AGGRESCAN):
4.47
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1699 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1699
Peptide:
SFNNGDCFILD
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
209-219
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
45.45
NuAPRpred:
-0.16
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-5.1
Area of the profile Above Threshold (AGGRESCAN):
2.77
Best Energy Score (PASTA 2.0):
-3.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1700 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1700
Peptide:
SFNNGNCFILD
Length:
11
Classification:
Amyloid
Mutation(s):
D214N
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
209-219
Literature
PMID:
10767822
Reference:
J Clin Pathol. 2000 Feb;53(2):95-9.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
45.45
NuAPRpred:
2.51
Tango:
1.04
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.2
Area of the profile Above Threshold (AGGRESCAN):
2.98
Best Energy Score (PASTA 2.0):
-3.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1701 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
P
H
R
P
A
P
A
L
L
C
A
L
S
L
A
L
C
A
L
S
L
P
V
R
A
A
T
A
S
R
G
A
S
Q
A
G
A
P
Q
G
R
V
P
E
A
R
P
N
S
M
V
V
E
H
P
E
F
L
60
61
K
A
G
K
E
P
G
L
Q
I
W
R
V
E
K
F
D
L
V
P
V
P
T
N
L
Y
G
D
F
F
T
G
D
A
Y
V
I
L
K
T
V
Q
L
R
N
G
N
L
Q
Y
D
L
H
Y
W
L
G
N
E
C
120
121
S
Q
D
E
S
G
A
A
A
I
F
T
V
Q
L
D
D
Y
L
N
G
R
A
V
Q
H
R
E
V
Q
G
F
E
S
A
T
F
L
G
Y
F
K
S
G
L
K
Y
K
K
G
G
V
A
S
G
F
K
H
V
V
180
181
P
N
E
V
V
V
Q
R
L
F
Q
V
K
G
R
R
V
V
R
A
T
E
V
P
V
S
W
E
S
F
N
N
G
D
C
F
I
L
D
L
G
N
N
I
H
Q
W
C
G
S
N
S
N
R
Y
E
R
L
K
A
240
241
T
Q
V
S
K
G
I
R
D
N
E
R
S
G
R
A
R
V
H
V
S
E
E
G
T
E
P
E
A
M
L
Q
V
L
G
P
K
P
A
L
P
A
G
T
E
D
T
A
K
E
D
A
A
N
R
K
L
A
K
L
300
301
Y
K
V
S
N
G
A
G
T
M
S
V
S
L
V
A
D
E
N
P
F
A
Q
G
A
L
K
S
E
D
C
F
I
L
D
H
G
K
D
G
K
I
F
V
W
K
G
K
Q
A
N
T
E
E
R
K
A
A
L
K
360
361
T
A
S
D
F
I
T
K
M
D
Y
P
K
Q
T
Q
V
S
V
L
P
E
G
G
E
T
P
L
F
K
Q
F
F
K
N
W
R
D
P
D
Q
T
D
G
L
G
L
S
Y
L
S
S
H
I
A
N
V
E
R
V
420
421
P
F
D
A
A
T
L
H
T
S
T
A
M
A
A
Q
H
G
M
D
D
D
G
T
G
Q
K
Q
I
W
R
I
E
G
S
N
K
V
P
V
D
P
A
T
Y
G
Q
F
Y
G
G
D
S
Y
I
I
L
Y
N
Y
480
481
R
H
G
G
R
Q
G
Q
I
I
Y
N
W
Q
G
A
Q
S
T
Q
D
E
V
A
A
S
A
I
L
T
A
Q
L
D
E
E
L
G
G
T
P
V
Q
S
R
V
V
Q
G
K
E
P
A
H
L
M
S
L
F
G
540
541
G
K
P
M
I
I
Y
K
G
G
T
S
R
E
G
G
Q
T
A
P
A
S
T
R
L
F
Q
V
R
A
N
S
A
G
A
T
R
A
V
E
V
L
P
K
A
G
A
L
N
S
N
D
A
F
V
L
K
T
P
S
600
601
A
A
Y
L
W
V
G
T
G
A
S
E
A
E
K
T
G
A
Q
E
L
L
R
V
L
R
A
Q
P
V
Q
V
A
E
G
S
E
P
D
G
F
W
E
A
L
G
G
K
A
A
Y
R
T
S
P
R
L
K
D
K
660
661
K
M
D
A
H
P
P
R
L
F
A
C
S
N
K
I
G
R
F
V
I
E
E
V
P
G
E
L
M
Q
E
D
L
A
T
D
D
V
M
L
L
D
T
W
D
Q
V
F
V
W
V
G
K
D
S
Q
E
E
E
K
720
721
T
E
A
L
T
S
A
K
R
Y
I
E
T
D
P
A
N
R
D
R
R
T
P
I
T
V
V
K
Q
G
F
E
P
P
S
F
V
G
W
F
L
G
W
D
D
D
Y
W
S
V
D
P
L
D
R
A
M
A
E
L
780
781
A
A
782
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1701
Peptide:
SFNNGYCFILD
Length:
11
Classification:
Amyloid
Mutation(s):
D214Y
Structure(s):
No structures
Protein Information
UniProt ID:
P06396
UniProt Name:
GELS_HUMAN
Protein Name:
Gelsolin (AGEL)
Position:
209-219
Literature
PMID:
10767822
Reference:
J Clin Pathol. 2000 Feb;53(2):95-9.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
54.55
NuAPRpred:
3.56
Tango:
87.87
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
22.1
Area of the profile Above Threshold (AGGRESCAN):
4.32
Best Energy Score (PASTA 2.0):
-4.12
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1702 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
V
W
S
L
S
L
P
S
C
L
L
S
L
L
L
L
L
Q
L
S
R
S
Y
A
G
Q
F
R
V
I
G
P
G
H
P
I
R
A
L
V
G
D
E
A
E
L
P
C
R
I
S
P
G
K
N
A
T
60
61
G
M
E
V
G
W
Y
R
S
P
F
S
R
V
V
H
L
Y
R
N
G
K
D
Q
D
A
E
Q
A
P
E
Y
R
G
R
T
E
L
L
K
E
S
I
G
E
G
K
V
A
L
R
I
Q
N
V
R
F
S
D
E
120
121
G
G
Y
T
C
F
F
R
D
H
S
Y
Q
E
E
A
A
V
E
L
K
V
E
D
P
F
Y
W
I
N
P
G
V
L
A
L
I
A
L
V
P
M
L
L
L
Q
V
S
V
G
L
V
F
L
F
L
Q
H
R
L
180
181
R
G
K
L
R
A
E
V
E
N
L
H
R
T
F
D
P
H
F
L
R
V
P
C
W
K
I
T
L
F
V
I
V
P
V
L
G
P
L
V
A
L
I
I
C
Y
N
W
L
H
R
R
L
A
G
Q
F
L
E
E
240
241
L
R
N
P
F
245
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1702
Peptide:
VALRIQNVRFS
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q63345
UniProt Name:
MOG_RAT
Protein Name:
Myelin-oligodendrocyte glycoprotein
Position:
108-118
Literature
PMID:
18684013
Reference:
PLoS Biol. 2008 Aug 5;6(8):e195.
source:
CPAD
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
54.55
NuAPRpred:
-1.71
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.4
Area of the profile Above Threshold (AGGRESCAN):
1.42
Best Energy Score (PASTA 2.0):
-3.53
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1703 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1703
Peptide:
VTGVTAVQKTV
Length:
11
Classification:
Amyloid
Mutation(s):
[del]78A
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
71-82
Literature
PMID:
11060312
Reference:
J Biol Chem. 2001 Jan 26;276(4):2380-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
45.45
NuAPRpred:
-0.77
Tango:
0.84
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.6
Area of the profile Above Threshold (AGGRESCAN):
2.21
Best Energy Score (PASTA 2.0):
-4.34
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1704 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
Q
A
F
R
K
F
L
P
L
F
D
R
V
L
V
E
R
S
A
A
E
T
V
T
K
G
G
I
M
L
P
E
K
S
Q
G
K
V
L
Q
A
T
V
V
A
V
G
S
G
G
K
G
K
G
G
E
I
60
61
Q
P
V
S
V
K
V
G
D
K
V
L
L
P
E
Y
G
G
T
K
V
V
L
D
D
K
D
Y
F
L
F
R
D
G
D
I
L
G
K
Y
V
D
102
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1704
Peptide:
VVLDDKDYFLF
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P26772
UniProt Name:
CH10_RAT
Protein Name:
heat shock protein, mitochondrial (Hsp10)
Position:
81-91
Literature
PMID:
18329043
Reference:
J Mol Biol. 2008 Apr 11;377(5):1593-606.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
63.64
NuAPRpred:
-1.62
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.3
Area of the profile Above Threshold (AGGRESCAN):
4.01
Best Energy Score (PASTA 2.0):
-3.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1705 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
S
H
R
L
L
L
L
C
L
A
G
L
V
F
V
S
E
A
G
P
T
G
T
G
E
S
K
C
P
L
M
V
K
V
L
D
A
V
R
G
S
P
A
I
N
V
A
V
H
V
F
R
K
A
A
D
D
T
60
61
W
E
P
F
A
S
G
K
T
S
E
S
G
E
L
H
G
L
T
T
E
E
E
F
V
E
G
I
Y
K
V
E
I
D
T
K
S
Y
W
K
A
L
G
I
S
P
F
H
E
H
A
E
V
V
F
T
A
N
D
S
120
121
G
P
R
R
Y
T
I
A
A
L
L
S
P
Y
S
Y
S
T
T
A
V
V
T
N
P
K
E
147
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1705
Peptide:
YTIAALLSPYS
Length:
11
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02766
UniProt Name:
TTHY_HUMAN
Protein Name:
Transthyretin (ATTR) (Prealbumin) (TBPA)
Position:
125-135
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
72.73
NuAPRpred:
0.72
Tango:
135.73
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
36.8
Area of the profile Above Threshold (AGGRESCAN):
4.35
Best Energy Score (PASTA 2.0):
-3.0
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1706 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1706
Peptide:
YTSPHQGAGMV
Length:
11
Classification:
Non-amyloid
Mutation(s):
C84T
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
83-93
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
45.45
NuAPRpred:
-3.43
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-26.4
Area of the profile Above Threshold (AGGRESCAN):
0.68
Best Energy Score (PASTA 2.0):
-0.35
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1707 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
G
G
V
L
L
V
L
L
L
C
V
A
A
Q
C
R
Q
R
G
L
F
P
A
I
L
N
L
A
S
N
A
H
I
S
T
N
A
T
C
G
E
K
G
P
E
M
F
C
K
L
V
E
H
V
P
G
R
P
60
61
V
R
N
P
Q
C
R
I
C
D
G
N
S
A
N
P
R
E
R
H
P
I
S
H
A
I
D
G
T
N
N
W
W
Q
S
P
S
I
Q
N
G
R
E
Y
H
W
V
T
I
T
L
D
L
R
Q
V
F
Q
V
A
120
121
Y
V
I
I
K
A
A
N
A
P
R
P
G
N
W
I
L
E
R
S
L
D
G
T
T
F
S
P
W
Q
Y
Y
A
V
S
D
S
E
C
L
S
R
Y
N
I
T
P
R
R
G
P
P
T
Y
R
A
D
D
E
V
180
181
I
C
T
S
Y
Y
S
R
L
V
P
L
E
H
G
E
I
H
T
S
L
I
N
G
R
P
S
A
D
D
L
S
P
K
L
L
E
F
T
S
A
R
Y
I
R
L
R
L
Q
R
I
R
T
L
N
A
D
L
M
T
240
241
L
S
H
R
E
P
K
E
L
D
P
I
V
T
R
R
Y
Y
Y
S
I
K
D
I
S
V
G
G
M
C
I
C
Y
G
H
A
S
S
C
P
W
D
E
T
T
K
K
L
Q
C
Q
C
E
H
N
T
C
G
E
S
300
301
C
N
R
C
C
P
G
Y
H
Q
Q
P
W
R
P
G
T
V
S
S
G
N
T
C
E
A
C
N
C
H
N
K
A
K
D
C
Y
Y
D
E
S
V
A
K
Q
K
K
S
L
N
T
A
G
Q
F
R
G
G
G
V
360
361
C
I
N
C
L
Q
N
T
M
G
I
N
C
E
T
C
I
D
G
Y
Y
R
P
H
K
V
S
P
Y
E
D
E
P
C
R
P
C
N
C
D
P
V
G
S
L
S
S
V
C
I
K
D
D
L
H
S
D
L
H
N
420
421
G
K
Q
P
G
Q
C
P
C
K
E
G
Y
T
G
E
K
C
D
R
C
Q
L
G
Y
K
D
Y
P
T
C
V
S
C
G
C
N
P
V
G
S
A
S
D
E
P
C
T
G
P
C
V
C
K
E
N
V
E
G
K
480
481
A
C
D
R
C
K
P
G
F
Y
N
L
K
E
K
N
P
R
G
C
S
E
C
F
C
F
G
V
S
D
V
C
S
S
L
S
W
P
V
G
Q
V
N
S
M
S
G
W
L
V
T
D
L
I
S
P
R
K
I
P
540
541
S
Q
Q
D
A
L
G
G
R
H
Q
V
S
I
N
N
T
A
V
M
Q
R
L
A
P
K
Y
Y
W
A
A
P
E
A
Y
L
G
N
K
L
T
A
F
G
G
F
L
K
Y
T
V
S
Y
D
I
P
V
E
T
V
600
601
D
S
N
L
M
S
H
A
D
V
I
I
K
G
N
G
L
T
L
S
T
Q
A
E
G
L
S
L
Q
P
Y
E
E
Y
L
N
V
V
R
L
V
P
E
N
F
Q
D
F
H
S
K
R
Q
I
D
R
D
Q
L
M
660
661
T
V
L
A
N
V
T
H
L
L
I
R
A
N
Y
N
S
A
K
M
A
L
Y
R
L
E
S
V
S
L
D
I
A
S
S
N
A
I
D
L
V
V
A
A
D
V
E
H
C
E
C
P
Q
G
Y
T
G
T
S
C
720
721
E
S
C
L
S
G
Y
Y
R
V
D
G
I
L
F
G
G
I
C
Q
P
C
E
C
H
G
H
A
A
E
C
N
V
H
G
V
C
I
A
C
A
H
N
T
T
G
V
H
C
E
Q
C
L
P
G
F
Y
G
E
P
780
781
S
R
G
T
P
G
D
C
Q
P
C
A
C
P
L
T
I
A
S
N
N
F
S
P
T
C
H
L
N
D
G
D
E
V
V
C
D
W
C
A
P
G
Y
S
G
A
W
C
E
R
C
A
D
G
Y
Y
G
N
P
T
840
841
V
P
G
E
S
C
V
P
C
D
C
S
G
N
V
D
P
S
E
A
G
H
C
D
S
V
T
G
E
C
L
K
C
L
G
N
T
D
G
A
H
C
E
R
C
A
D
G
F
Y
G
D
A
V
T
A
K
N
C
R
900
901
A
C
E
C
H
V
K
G
S
H
S
A
V
C
H
L
E
T
G
L
C
D
C
K
P
N
V
T
G
Q
Q
C
D
Q
C
L
H
G
Y
Y
G
L
D
S
G
H
G
C
R
P
C
N
C
S
V
A
G
S
V
S
960
961
D
G
C
T
D
E
G
Q
C
H
C
V
P
G
V
A
G
K
R
C
D
R
C
A
H
G
F
Y
A
Y
Q
D
G
S
C
T
P
C
D
C
P
H
T
Q
N
T
C
D
P
E
T
G
E
C
V
C
P
P
H
T
1020
1021
Q
G
V
K
C
E
E
C
E
D
G
H
W
G
Y
D
A
E
V
G
C
Q
A
C
N
C
S
L
V
G
S
T
H
H
R
C
D
V
V
T
G
H
C
Q
C
K
S
K
F
G
G
R
A
C
D
Q
C
S
L
G
1080
1081
Y
R
D
F
P
D
C
V
P
C
D
C
D
L
R
G
T
S
G
D
A
C
N
L
E
Q
G
L
C
G
C
V
E
E
T
G
A
C
P
C
K
E
N
V
F
G
P
Q
C
N
E
C
R
E
G
T
F
A
L
R
1140
1141
A
D
N
P
L
G
C
S
P
C
F
C
S
G
L
S
H
L
C
S
E
L
E
D
Y
V
R
T
P
V
T
L
G
S
D
Q
P
L
L
R
V
V
S
Q
S
N
L
R
G
T
T
E
G
V
Y
Y
Q
A
P
D
1200
1201
F
L
L
D
A
A
T
V
R
Q
H
I
R
A
E
P
F
Y
W
R
L
P
Q
Q
F
Q
G
D
Q
L
M
A
Y
G
G
K
L
K
Y
S
V
A
F
Y
S
L
D
G
V
G
T
S
N
F
E
P
Q
V
L
I
1260
1261
K
G
G
R
I
R
K
Q
V
I
Y
M
D
A
P
A
P
E
N
G
V
R
Q
E
Q
E
V
A
M
R
E
N
F
W
K
Y
F
N
S
V
S
E
K
P
V
T
R
E
D
F
M
S
V
L
S
D
I
E
Y
I
1320
1321
L
I
K
A
S
Y
G
Q
G
L
Q
Q
S
R
I
S
D
I
S
M
E
V
G
R
K
A
E
K
L
H
P
E
E
E
V
A
S
L
L
E
N
C
V
C
P
P
G
T
V
G
F
S
C
Q
D
C
A
P
G
Y
1380
1381
H
R
G
K
L
P
A
G
S
D
R
G
P
R
P
L
V
A
P
C
V
P
C
S
C
N
N
H
S
D
T
C
D
P
N
T
G
K
C
L
N
C
G
D
N
T
A
G
D
H
C
D
V
C
T
S
G
Y
Y
G
1440
1441
K
V
T
G
S
A
S
D
C
A
L
C
A
C
P
H
S
P
P
A
S
F
S
P
T
C
V
L
E
G
D
H
D
F
R
C
D
A
C
L
L
G
Y
E
G
K
H
C
E
R
C
S
S
S
Y
Y
G
N
P
Q
1500
1501
T
P
G
G
S
C
Q
K
C
D
C
N
P
H
G
S
V
H
G
D
C
D
R
T
S
G
Q
C
V
C
R
L
G
A
S
G
L
R
C
D
E
C
E
P
R
H
I
L
M
E
T
D
C
V
S
C
D
D
E
C
1560
1561
V
G
V
L
L
N
D
L
D
E
I
G
D
A
V
L
S
L
N
L
T
G
I
I
P
V
P
Y
G
I
L
S
N
L
E
N
T
T
K
Y
L
Q
E
S
L
L
K
E
N
M
Q
K
D
L
G
K
I
K
L
E
1620
1621
G
V
A
E
E
T
D
N
L
Q
K
K
L
T
R
M
L
A
S
T
Q
K
V
N
R
A
T
E
R
I
F
K
E
S
Q
D
L
A
I
A
I
E
R
L
Q
M
S
I
T
E
I
M
E
K
T
T
L
N
Q
T
1680
1681
L
D
E
D
F
L
L
P
N
S
T
L
Q
N
M
Q
Q
N
G
T
S
L
L
E
I
M
Q
I
R
D
F
T
Q
L
H
Q
N
A
T
L
E
L
K
A
A
E
D
L
L
S
Q
I
Q
E
N
Y
Q
K
P
L
1740
1741
E
E
L
E
V
L
K
E
A
A
S
H
V
L
S
K
H
N
N
E
L
K
A
A
E
A
L
V
R
E
A
E
A
K
M
Q
E
S
N
H
L
L
L
M
V
N
A
N
L
R
E
F
S
D
K
K
L
H
V
Q
1800
1801
E
E
Q
N
L
T
S
E
L
I
V
Q
G
R
G
L
I
D
A
A
A
A
Q
T
D
A
V
Q
D
A
L
E
H
L
E
D
H
Q
D
K
L
L
L
W
S
A
K
I
R
H
H
I
D
D
L
V
M
H
M
S
1860
1861
Q
R
N
A
V
D
L
V
Y
R
A
E
D
H
A
A
E
F
Q
R
L
A
D
V
L
Y
S
G
L
E
N
I
R
N
V
S
L
N
A
T
S
A
A
Y
V
H
Y
N
I
Q
S
L
I
E
E
S
E
E
L
A
1920
1921
R
D
A
H
R
T
V
T
E
T
S
L
L
S
E
S
L
V
S
N
G
K
A
A
V
Q
R
S
S
R
F
L
K
E
G
N
N
L
S
R
K
L
P
G
I
A
L
E
L
S
E
L
R
N
K
T
N
R
F
Q
1980
1981
E
N
A
V
E
I
T
R
Q
T
N
E
S
L
L
I
L
R
A
I
P
K
G
I
R
D
K
G
A
K
T
K
E
L
A
T
S
A
S
Q
S
A
V
S
T
L
R
D
V
A
G
L
S
Q
E
L
L
N
T
S
2040
2041
A
S
L
S
R
V
N
T
T
L
R
E
T
H
Q
L
L
Q
D
S
T
M
A
T
L
L
A
G
R
K
V
K
D
V
E
I
Q
A
N
L
L
F
D
R
L
K
P
L
K
M
L
E
E
N
L
S
R
N
L
S
2100
2101
E
I
K
L
L
I
S
Q
A
R
K
Q
A
A
S
I
K
V
A
V
S
A
D
R
D
C
I
R
A
Y
Q
P
Q
I
S
S
T
N
Y
N
T
L
T
L
N
V
K
T
Q
E
P
D
N
L
L
F
Y
L
G
S
2160
2161
S
T
A
S
D
F
L
A
V
E
M
R
R
G
R
V
A
F
L
W
D
L
G
S
G
S
T
R
L
E
F
P
D
F
P
I
D
D
N
R
W
H
S
I
H
V
A
R
F
G
N
I
G
S
L
S
V
K
E
M
2220
2221
S
S
N
Q
K
S
P
T
K
T
S
K
S
P
G
T
A
N
V
L
D
V
N
N
S
T
L
M
F
V
G
G
L
G
G
Q
I
K
K
S
P
A
V
K
V
T
H
F
K
G
C
L
G
E
A
F
L
N
G
K
2280
2281
S
I
G
L
W
N
Y
I
E
R
E
G
K
C
R
G
C
F
G
S
S
Q
N
E
D
P
S
F
H
F
D
G
S
G
Y
S
V
V
E
K
S
L
P
A
T
V
T
Q
I
I
M
L
F
N
T
F
S
P
N
G
2340
2341
L
L
L
Y
L
G
S
Y
G
T
K
D
F
L
S
I
E
L
F
R
G
R
V
K
V
M
T
D
L
G
S
G
P
I
T
L
L
T
D
R
R
Y
N
N
G
T
W
Y
K
I
A
F
Q
R
N
R
K
Q
G
V
2400
2401
L
A
V
I
D
A
Y
N
T
S
N
K
E
T
K
Q
G
E
T
P
G
A
S
S
D
L
N
R
L
D
K
D
P
I
Y
V
G
G
L
P
R
S
R
V
V
R
R
G
V
T
T
K
S
F
V
G
C
I
K
N
2460
2461
L
E
I
S
R
S
T
F
D
L
L
R
N
S
Y
G
V
R
K
G
C
L
L
E
P
I
R
S
V
S
F
L
K
G
G
Y
I
E
L
P
P
K
S
L
S
P
E
S
E
W
L
V
T
F
A
T
T
N
S
S
2520
2521
G
I
I
L
A
A
L
G
G
D
V
E
K
R
G
D
R
E
E
A
H
V
P
F
F
S
V
M
L
I
G
G
N
I
E
V
H
V
N
P
G
D
G
T
G
L
R
K
A
L
L
H
A
P
T
G
T
C
S
D
2580
2581
G
Q
A
H
S
I
S
L
V
R
N
R
R
I
I
T
V
Q
L
D
E
N
N
P
V
E
M
K
L
G
T
L
V
E
S
R
T
I
N
V
S
N
L
Y
V
G
G
I
P
E
G
E
G
T
S
L
L
T
M
R
2640
2641
R
S
F
H
G
C
I
K
N
L
I
F
N
L
E
L
L
D
F
N
S
A
V
G
H
E
Q
V
D
L
D
T
C
W
L
S
E
R
P
K
L
A
P
D
A
E
D
S
K
L
L
P
E
P
R
A
F
P
E
Q
2700
2701
C
V
V
D
A
A
L
E
Y
V
P
G
A
H
Q
F
G
L
T
Q
N
S
H
F
I
L
P
F
N
Q
S
A
V
R
K
K
L
S
V
E
L
S
I
R
T
F
A
S
S
G
L
I
Y
Y
M
A
H
Q
N
Q
2760
2761
A
D
Y
A
V
L
Q
L
H
G
G
R
L
H
F
M
F
D
L
G
K
G
R
T
K
V
S
H
P
A
L
L
S
D
G
K
W
H
T
V
K
T
D
Y
V
K
R
K
G
F
I
T
V
D
G
R
E
S
P
M
2820
2821
V
T
V
V
G
D
G
T
M
L
D
V
E
G
L
F
Y
L
G
G
L
P
S
Q
Y
Q
A
R
K
I
G
N
I
T
H
S
I
P
A
C
I
G
D
V
T
V
N
S
K
Q
L
D
K
D
S
P
V
S
A
F
2880
2881
T
V
N
R
C
Y
A
V
A
Q
E
G
T
Y
F
D
G
S
G
Y
A
A
L
V
K
E
G
Y
K
V
Q
S
D
V
N
I
T
L
E
F
R
T
S
S
Q
N
G
V
L
L
G
I
S
T
A
K
V
D
A
I
2940
2941
G
L
E
L
V
D
G
K
V
L
F
H
V
N
N
G
A
G
R
I
T
A
A
Y
E
P
K
T
A
T
V
L
C
D
G
K
W
H
T
L
Q
A
N
K
S
K
H
R
I
T
L
I
V
D
G
N
A
V
G
A
3000
3001
E
S
P
H
T
Q
S
T
S
V
D
T
N
N
P
I
Y
V
G
G
Y
P
A
G
V
K
Q
K
C
L
R
S
Q
T
S
F
R
G
C
L
R
K
L
A
L
I
K
S
P
Q
V
Q
S
F
D
F
S
R
A
F
3060
3061
E
L
H
G
V
F
L
H
S
C
P
G
T
E
S
3075
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1707
Peptide:
AASIKVAVSADR
Length:
12
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P25391
UniProt Name:
LAMA1_HUMAN
Protein Name:
Laminin subunit alpha-1 (Laminin A chain)
Position:
2113-2125
Literature
PMID:
17348688
Reference:
Biochemistry. 2007 Apr 3;46(13):3966-74.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
58.33
NuAPRpred:
0.09
Tango:
20.98
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
3.1
Area of the profile Above Threshold (AGGRESCAN):
2.85
Best Energy Score (PASTA 2.0):
-4.14
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1708 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1708
Peptide:
DISTKYFQMSLE
Length:
12
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P02469
UniProt Name:
LAMB1_MOUSE
Protein Name:
Laminin subunit beta-1 (Laminin B1 chain)
Position:
Literature
PMID:
17348688
Reference:
Biochemistry. 2007 Apr 3;46(13):3966-74.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
41.67
NuAPRpred:
-1.24
Tango:
1.71
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
4.9
Area of the profile Above Threshold (AGGRESCAN):
2.16
Best Energy Score (PASTA 2.0):
-1.99
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1709 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1709
Peptide:
FHPSDIEVDLLK
Length:
12
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
50-61
Literature
PMID:
12488093
Reference:
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
50.0
NuAPRpred:
-1.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-13.8
Area of the profile Above Threshold (AGGRESCAN):
0.91
Best Energy Score (PASTA 2.0):
-2.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1710 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
R
T
A
Q
L
R
K
A
N
D
Q
S
G
R
C
Q
Y
T
F
S
V
A
S
P
N
E
S
S
C
P
E
Q
S
Q
A
M
S
V
I
H
N
L
Q
R
D
S
S
T
Q
R
L
D
L
E
A
T
K
A
R
L
60
61
S
S
L
E
S
L
L
H
Q
L
T
L
D
Q
A
A
R
P
Q
E
T
Q
E
G
L
Q
R
E
L
G
T
L
R
R
E
R
D
Q
L
E
T
Q
T
R
E
L
E
T
A
Y
S
N
L
L
R
D
K
S
V
L
120
121
E
E
E
K
K
R
L
R
Q
E
N
E
N
L
A
R
R
L
E
S
S
S
Q
E
V
A
R
L
R
R
G
Q
C
P
Q
T
R
D
T
A
R
A
V
P
P
G
S
R
E
V
S
T
W
N
L
D
T
L
A
F
180
181
Q
E
L
K
S
E
L
T
E
V
P
A
S
R
I
L
K
E
S
P
S
G
Y
L
R
S
G
E
G
D
T
G
C
G
E
L
V
W
V
G
E
P
L
T
L
R
T
A
E
T
I
T
G
K
Y
G
V
W
M
R
240
241
D
P
K
P
T
Y
P
Y
T
Q
E
T
T
W
R
I
D
T
V
G
T
D
V
R
Q
V
F
E
Y
D
L
I
S
Q
F
M
Q
G
Y
P
S
K
V
H
I
L
P
R
P
L
E
S
T
G
A
V
V
Y
S
G
300
301
S
L
Y
F
Q
G
A
E
S
R
T
V
I
R
Y
E
L
N
T
E
T
V
K
A
E
K
E
I
P
G
A
G
Y
H
G
Q
F
P
Y
S
W
G
G
Y
T
D
I
D
L
A
V
D
E
A
G
L
W
V
I
Y
360
361
S
T
D
E
A
K
G
A
I
V
L
S
K
L
N
P
E
N
L
E
L
E
Q
T
W
E
T
N
I
R
K
Q
S
V
A
N
A
F
I
I
C
G
T
L
Y
T
V
S
S
Y
T
S
A
D
A
T
V
N
F
A
420
421
Y
D
T
G
T
G
I
S
K
T
L
T
I
P
F
K
N
R
Y
K
Y
S
S
M
I
D
Y
N
P
L
E
K
K
L
F
A
W
D
N
L
N
M
V
T
Y
D
I
K
L
S
K
M
472
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1710
Peptide:
GAVVYSGSLYFQ
Length:
12
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q99972
UniProt Name:
MYOC_HUMAN
Protein Name:
Myocilin
Position:
294-305
Literature
PMID:
24333014
Reference:
J Mol Biol. 2014 Feb 20;426(4):921-35
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
58.33
NuAPRpred:
1.32
Tango:
701.07
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
46.6
Area of the profile Above Threshold (AGGRESCAN):
5.94
Best Energy Score (PASTA 2.0):
-3.94
Aggregate Orientation (PASTA 2.0):
-
