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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1741 to 1770 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1741
PGGGKNAEVYKPV
13
Non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
AmyLoad
P-1742
PGGGKVQIVEKPV
13
Non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
AmyLoad
P-1743
PGGGKVQIVYKPV
13
Amyloid
Microtubule-associated protein tau (PHF-tau)
P10636-2
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
CPAD, AmyLoad
P-1744
PHNVVFDEDDEIP
13
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1745
VHHQKLVFFAEDV
13
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
P-1746
AAFHRWSSYMVHWK
14
Non-amyloid
Acetylcholinesterase (AChE)
P22303
E2A
PLoS One. 2008 Mar 19;3(3):e1834
18350169
CPAD
P-1747
AEAHRWSSYMVHWK
14
Amyloid
Acetylcholinesterase (AChE)
P22303
F3A
PLoS One. 2008 Mar 19;3(3):e1834
18350169
CPAD
P-1748
AEFARWSSYMVHWK
14
Amyloid
Acetylcholinesterase (AChE)
P22303
H4A
PLoS One. 2008 Mar 19;3(3):e1834
18350169
CPAD
P-1749
AEFHRWSAYMVHWK
14
Amyloid
Acetylcholinesterase (AChE)
P22303
S8A
PLoS One. 2008 Mar 19;3(3):e1834
18350169
CPAD
P-1750
AEFHRWSSAMVHWK
14
Amyloid
Acetylcholinesterase (AChE)
P22303
Y9A
PLoS One. 2008 Mar 19;3(3):e1834
18350169
CPAD
P-1751
AEFHRWSSYMVHWA
14
Non-amyloid
Acetylcholinesterase (AChE)
P22303
K14A
PLoS One. 2008 Mar 19;3(3):e1834
18350169
CPAD
P-1752
AEFHRWSSYMVHWK
14
Amyloid
Acetylcholinesterase (AChE)
P22303
No
Biochemistry. 2002 Nov 19;41(46):13539-47.
12427014
CPAD
P-1753
AEFHRWSSYMVYWK
14
Amyloid
Acetylcholinesterase (AChE)
P22303
H597Y
Biochemistry. 2002 Nov 19;41(46):13539-47.
12427014
AmyLoad
P-1754
AVVGGLGGYMLGSA
14
Amyloid
Major prion protein (PrP)
P04156
No
J Mol Biol. 1997 Dec 5;274(3):381-93.
9405147
CPAD
P-1755
DCVNITIKQHTVTT
14
Amyloid
Major prion protein (PrP)
P04156
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1756
DFVIFLDVKHFSPE
14
Amyloid
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
P02489
K70D
Biochemistry. 2008 Mar 4;47(9):2961-7.
18232642
CPAD
P-1757
DNNNSANYQVSTSK
14
Amyloid
synthetic
Biochem Biophys Res Commun. 2008 Dec 19;377(3):966-70.
18952064
CPAD
P-1758
FKSAEDSMRTSGGA
14
Non-amyloid
Pancreatic trypsin inhibitor (Aprotinin)
P00974
C86S, C90S
J Mol Biol. 1993 Dec 5;234(3):861-78.
7504737
AmyLoad
P-1759
LVEVGGDVQLDSVR
14
Amyloid
Galectin-7
P47929
No
J Biol Chem. 2014 Oct 17;289(42):29195-207
25172508
CPAD
P-1760
MKHMAGAAAAGAVV
14
Amyloid
Major prion protein (PrP)
P04156
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1761
RVEKVAILGLMVLA
14
Amyloid
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1762
SFFSFLGEAFDGAR
14
Amyloid
FEBS Lett. 1995 Sep 4;371(2):110-4.
7672107
CPAD
P-1763
VEAKFINYVKNCFR
14
Amyloid
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23)
P06748
No
FASEB J. 2015 Sep;29(9):3689-701.
25977257
AmyLoad
P-1764
VGDIVIFNDGYGVK
14
Amyloid
chaperonin (GroES protein) (Protein Cpn10)
P0A6F9
No
J Mol Biol. 2008 Apr 11;377(5):1593-606.
18329043
CPAD
P-1765
VNITIKQHTVTTTT
14
Amyloid
Major prion protein (PrP)
P04156
No
J Neurosci Res. 2000 Oct 15;62(2):293-301.
11020222
CPAD
P-1766
AGAAAAGAVVGGLGG
15
Amyloid
Major prion protein (PrP)
P04156
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
16537487
CPAD, AmyLoad
P-1767
EDGVDALNKLQAGGY
15
Non-amyloid
Chemotaxis protein CheY
Q93P00
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1768
EPSEQFIKQHDFSSY
15
Non-amyloid
Transcriptional regulatory protein ComA (Competence protein A)
P14204
No
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1769
EVEDYFEEAIRAGLH
15
Non-amyloid
Transcriptional regulatory protein ComA (Competence protein A)
P14204
No
Protein Sci. 1995 Aug;4(8):1577-86.
8520484
AmyLoad
P-1770
EVHHQKLVFFAEDVG
15
Amyloid
Amyloid-beta precursor protein (APP)
P05067
No
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
7827029
1
CPAD, AmyLoad
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Entry: P-1741 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1741
Peptide:
PGGGKNAEVYKPV
Length:
13
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
46.15
NuAPRpred:
-3.63
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-29.4
Area of the profile Above Threshold (AGGRESCAN):
0.89
Best Energy Score (PASTA 2.0):
-2.13
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1742 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1742
Peptide:
PGGGKVQIVEKPV
Length:
13
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
46.15
NuAPRpred:
-0.66
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.2
Area of the profile Above Threshold (AGGRESCAN):
1.54
Best Energy Score (PASTA 2.0):
-4.55
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1743 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
E
P
R
Q
E
F
E
V
M
E
D
H
A
G
T
Y
G
L
G
D
R
K
D
Q
G
G
Y
T
M
H
Q
D
Q
E
G
D
T
D
A
G
L
K
A
E
E
A
G
I
G
D
T
P
S
L
E
D
E
A
60
61
A
G
H
V
T
Q
A
R
M
V
S
K
S
K
D
G
T
G
S
D
D
K
K
A
K
G
A
D
G
K
T
K
I
A
T
P
R
G
A
A
P
P
G
Q
K
G
Q
A
N
A
T
R
I
P
A
K
T
P
P
A
120
121
P
K
T
P
P
S
S
G
E
P
P
K
S
G
D
R
S
G
Y
S
S
P
G
S
P
G
T
P
G
S
R
S
R
T
P
S
L
P
T
P
P
T
R
E
P
K
K
V
A
V
V
R
T
P
P
K
S
P
S
S
180
181
A
K
S
R
L
Q
T
A
P
V
P
M
P
D
L
K
N
V
K
S
K
I
G
S
T
E
N
L
K
H
Q
P
G
G
G
K
V
Q
I
V
Y
K
P
V
D
L
S
K
V
T
S
K
C
G
S
L
G
N
I
H
240
241
H
K
P
G
G
G
Q
V
E
V
K
S
E
K
L
D
F
K
D
R
V
Q
S
K
I
G
S
L
D
N
I
T
H
V
P
G
G
G
N
K
K
I
E
T
H
K
L
T
F
R
E
N
A
K
A
K
T
D
H
G
300
301
A
E
I
V
Y
K
S
P
V
V
S
G
D
T
S
P
R
H
L
S
N
V
S
S
T
G
S
I
D
M
V
D
S
P
Q
L
A
T
L
A
D
E
V
S
A
S
L
A
K
Q
G
L
352
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1743
Peptide:
PGGGKVQIVYKPV
Length:
13
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636-2
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
212-224
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
53.85
NuAPRpred:
-0.09
Tango:
13.68
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.5
Area of the profile Above Threshold (AGGRESCAN):
3.68
Best Energy Score (PASTA 2.0):
-4.98
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1744 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
Position information is not in the expected format. Please contact admin/developer.
Peptide details
Entry:
P-1744
Peptide:
PHNVVFDEDDEIP
Length:
13
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
[del]D45
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
-5
Absolute Charge:
5
Hydrophobicity:
46.15
NuAPRpred:
-2.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-43.0
Area of the profile Above Threshold (AGGRESCAN):
1.4
Best Energy Score (PASTA 2.0):
-4.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1745 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1745
Peptide:
VHHQKLVFFAEDV
Length:
13
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
683-695
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30; J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
53.85
NuAPRpred:
2.25
Tango:
433.92
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
0.9
Area of the profile Above Threshold (AGGRESCAN):
3.82
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1746 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
Q
C
L
L
H
T
P
S
L
A
S
P
L
L
L
L
L
L
W
L
L
G
G
G
V
G
A
E
G
R
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
G
I
R
L
K
T
P
G
G
P
V
60
61
S
A
F
L
G
I
P
F
A
E
P
P
M
G
P
R
R
F
L
P
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
M
W
N
P
N
120
121
R
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
G
G
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
A
E
R
T
V
L
V
S
M
180
181
N
Y
R
V
G
A
F
G
F
L
A
L
P
G
S
R
E
A
P
G
N
V
G
L
L
D
Q
R
L
A
L
Q
W
V
Q
E
N
V
A
A
F
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
A
A
S
V
240
241
G
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
P
P
G
G
T
G
G
N
D
T
E
L
300
301
V
A
C
L
R
T
R
P
A
Q
V
L
V
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
P
V
V
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
G
D
F
H
G
L
Q
V
L
V
G
360
361
V
V
K
D
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
P
E
420
421
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
V
C
P
V
A
Q
L
A
G
R
L
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
P
H
G
Y
480
481
E
I
E
F
I
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
G
D
P
N
E
P
R
D
P
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
540
541
Y
V
S
L
D
L
R
P
L
E
V
R
R
G
L
R
A
Q
A
C
A
F
W
N
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
W
K
A
E
F
H
R
W
S
S
Y
M
V
H
W
K
N
600
601
Q
F
D
H
Y
S
K
Q
D
R
C
S
D
L
614
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1746
Peptide:
AAFHRWSSYMVHWK
Length:
14
Classification:
Non-amyloid
Mutation(s):
E2A
Structure(s):
No structures
Protein Information
UniProt ID:
P22303
UniProt Name:
ACES_HUMAN
Protein Name:
Acetylcholinesterase (AChE)
Position:
586-599
Literature
PMID:
18350169
Reference:
PLoS One. 2008 Mar 19;3(3):e1834
source:
CPAD
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
57.14
NuAPRpred:
-1.09
Tango:
1.39
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
12.9
Area of the profile Above Threshold (AGGRESCAN):
3.01
Best Energy Score (PASTA 2.0):
-3.92
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1747 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
Q
C
L
L
H
T
P
S
L
A
S
P
L
L
L
L
L
L
W
L
L
G
G
G
V
G
A
E
G
R
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
G
I
R
L
K
T
P
G
G
P
V
60
61
S
A
F
L
G
I
P
F
A
E
P
P
M
G
P
R
R
F
L
P
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
M
W
N
P
N
120
121
R
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
G
G
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
A
E
R
T
V
L
V
S
M
180
181
N
Y
R
V
G
A
F
G
F
L
A
L
P
G
S
R
E
A
P
G
N
V
G
L
L
D
Q
R
L
A
L
Q
W
V
Q
E
N
V
A
A
F
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
A
A
S
V
240
241
G
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
P
P
G
G
T
G
G
N
D
T
E
L
300
301
V
A
C
L
R
T
R
P
A
Q
V
L
V
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
P
V
V
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
G
D
F
H
G
L
Q
V
L
V
G
360
361
V
V
K
D
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
P
E
420
421
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
V
C
P
V
A
Q
L
A
G
R
L
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
P
H
G
Y
480
481
E
I
E
F
I
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
G
D
P
N
E
P
R
D
P
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
540
541
Y
V
S
L
D
L
R
P
L
E
V
R
R
G
L
R
A
Q
A
C
A
F
W
N
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
W
K
A
E
F
H
R
W
S
S
Y
M
V
H
W
K
N
600
601
Q
F
D
H
Y
S
K
Q
D
R
C
S
D
L
614
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1747
Peptide:
AEAHRWSSYMVHWK
Length:
14
Classification:
Amyloid
Mutation(s):
F3A
Structure(s):
No structures
Protein Information
UniProt ID:
P22303
UniProt Name:
ACES_HUMAN
Protein Name:
Acetylcholinesterase (AChE)
Position:
586-599
Literature
PMID:
18350169
Reference:
PLoS One. 2008 Mar 19;3(3):e1834
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-1.18
Tango:
1.6
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-7.7
Area of the profile Above Threshold (AGGRESCAN):
2.83
Best Energy Score (PASTA 2.0):
-3.44
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1748 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
Q
C
L
L
H
T
P
S
L
A
S
P
L
L
L
L
L
L
W
L
L
G
G
G
V
G
A
E
G
R
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
G
I
R
L
K
T
P
G
G
P
V
60
61
S
A
F
L
G
I
P
F
A
E
P
P
M
G
P
R
R
F
L
P
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
M
W
N
P
N
120
121
R
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
G
G
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
A
E
R
T
V
L
V
S
M
180
181
N
Y
R
V
G
A
F
G
F
L
A
L
P
G
S
R
E
A
P
G
N
V
G
L
L
D
Q
R
L
A
L
Q
W
V
Q
E
N
V
A
A
F
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
A
A
S
V
240
241
G
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
P
P
G
G
T
G
G
N
D
T
E
L
300
301
V
A
C
L
R
T
R
P
A
Q
V
L
V
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
P
V
V
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
G
D
F
H
G
L
Q
V
L
V
G
360
361
V
V
K
D
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
P
E
420
421
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
V
C
P
V
A
Q
L
A
G
R
L
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
P
H
G
Y
480
481
E
I
E
F
I
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
G
D
P
N
E
P
R
D
P
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
540
541
Y
V
S
L
D
L
R
P
L
E
V
R
R
G
L
R
A
Q
A
C
A
F
W
N
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
W
K
A
E
F
H
R
W
S
S
Y
M
V
H
W
K
N
600
601
Q
F
D
H
Y
S
K
Q
D
R
C
S
D
L
614
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1748
Peptide:
AEFARWSSYMVHWK
Length:
14
Classification:
Amyloid
Mutation(s):
H4A
Structure(s):
No structures
Protein Information
UniProt ID:
P22303
UniProt Name:
ACES_HUMAN
Protein Name:
Acetylcholinesterase (AChE)
Position:
586-599
Literature
PMID:
18350169
Reference:
PLoS One. 2008 Mar 19;3(3):e1834
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
57.14
NuAPRpred:
-1.45
Tango:
2.57
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
13.6
Area of the profile Above Threshold (AGGRESCAN):
3.13
Best Energy Score (PASTA 2.0):
-3.44
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1749 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
Q
C
L
L
H
T
P
S
L
A
S
P
L
L
L
L
L
L
W
L
L
G
G
G
V
G
A
E
G
R
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
G
I
R
L
K
T
P
G
G
P
V
60
61
S
A
F
L
G
I
P
F
A
E
P
P
M
G
P
R
R
F
L
P
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
M
W
N
P
N
120
121
R
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
G
G
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
A
E
R
T
V
L
V
S
M
180
181
N
Y
R
V
G
A
F
G
F
L
A
L
P
G
S
R
E
A
P
G
N
V
G
L
L
D
Q
R
L
A
L
Q
W
V
Q
E
N
V
A
A
F
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
A
A
S
V
240
241
G
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
P
P
G
G
T
G
G
N
D
T
E
L
300
301
V
A
C
L
R
T
R
P
A
Q
V
L
V
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
P
V
V
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
G
D
F
H
G
L
Q
V
L
V
G
360
361
V
V
K
D
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
P
E
420
421
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
V
C
P
V
A
Q
L
A
G
R
L
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
P
H
G
Y
480
481
E
I
E
F
I
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
G
D
P
N
E
P
R
D
P
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
540
541
Y
V
S
L
D
L
R
P
L
E
V
R
R
G
L
R
A
Q
A
C
A
F
W
N
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
W
K
A
E
F
H
R
W
S
S
Y
M
V
H
W
K
N
600
601
Q
F
D
H
Y
S
K
Q
D
R
C
S
D
L
614
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1749
Peptide:
AEFHRWSAYMVHWK
Length:
14
Classification:
Amyloid
Mutation(s):
S8A
Structure(s):
No structures
Protein Information
UniProt ID:
P22303
UniProt Name:
ACES_HUMAN
Protein Name:
Acetylcholinesterase (AChE)
Position:
586-599
Literature
PMID:
18350169
Reference:
PLoS One. 2008 Mar 19;3(3):e1834
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
57.14
NuAPRpred:
-0.75
Tango:
7.84
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.9
Area of the profile Above Threshold (AGGRESCAN):
3.1
Best Energy Score (PASTA 2.0):
-3.9
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1750 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
Q
C
L
L
H
T
P
S
L
A
S
P
L
L
L
L
L
L
W
L
L
G
G
G
V
G
A
E
G
R
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
G
I
R
L
K
T
P
G
G
P
V
60
61
S
A
F
L
G
I
P
F
A
E
P
P
M
G
P
R
R
F
L
P
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
M
W
N
P
N
120
121
R
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
G
G
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
A
E
R
T
V
L
V
S
M
180
181
N
Y
R
V
G
A
F
G
F
L
A
L
P
G
S
R
E
A
P
G
N
V
G
L
L
D
Q
R
L
A
L
Q
W
V
Q
E
N
V
A
A
F
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
A
A
S
V
240
241
G
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
P
P
G
G
T
G
G
N
D
T
E
L
300
301
V
A
C
L
R
T
R
P
A
Q
V
L
V
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
P
V
V
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
G
D
F
H
G
L
Q
V
L
V
G
360
361
V
V
K
D
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
P
E
420
421
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
V
C
P
V
A
Q
L
A
G
R
L
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
P
H
G
Y
480
481
E
I
E
F
I
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
G
D
P
N
E
P
R
D
P
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
540
541
Y
V
S
L
D
L
R
P
L
E
V
R
R
G
L
R
A
Q
A
C
A
F
W
N
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
W
K
A
E
F
H
R
W
S
S
Y
M
V
H
W
K
N
600
601
Q
F
D
H
Y
S
K
Q
D
R
C
S
D
L
614
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1750
Peptide:
AEFHRWSSAMVHWK
Length:
14
Classification:
Amyloid
Mutation(s):
Y9A
Structure(s):
No structures
Protein Information
UniProt ID:
P22303
UniProt Name:
ACES_HUMAN
Protein Name:
Acetylcholinesterase (AChE)
Position:
586-599
Literature
PMID:
18350169
Reference:
PLoS One. 2008 Mar 19;3(3):e1834
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-2.15
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-3.5
Area of the profile Above Threshold (AGGRESCAN):
1.84
Best Energy Score (PASTA 2.0):
-3.0
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1751 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
Q
C
L
L
H
T
P
S
L
A
S
P
L
L
L
L
L
L
W
L
L
G
G
G
V
G
A
E
G
R
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
G
I
R
L
K
T
P
G
G
P
V
60
61
S
A
F
L
G
I
P
F
A
E
P
P
M
G
P
R
R
F
L
P
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
M
W
N
P
N
120
121
R
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
G
G
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
A
E
R
T
V
L
V
S
M
180
181
N
Y
R
V
G
A
F
G
F
L
A
L
P
G
S
R
E
A
P
G
N
V
G
L
L
D
Q
R
L
A
L
Q
W
V
Q
E
N
V
A
A
F
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
A
A
S
V
240
241
G
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
P
P
G
G
T
G
G
N
D
T
E
L
300
301
V
A
C
L
R
T
R
P
A
Q
V
L
V
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
P
V
V
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
G
D
F
H
G
L
Q
V
L
V
G
360
361
V
V
K
D
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
P
E
420
421
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
V
C
P
V
A
Q
L
A
G
R
L
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
P
H
G
Y
480
481
E
I
E
F
I
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
G
D
P
N
E
P
R
D
P
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
540
541
Y
V
S
L
D
L
R
P
L
E
V
R
R
G
L
R
A
Q
A
C
A
F
W
N
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
W
K
A
E
F
H
R
W
S
S
Y
M
V
H
W
K
N
600
601
Q
F
D
H
Y
S
K
Q
D
R
C
S
D
L
614
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1751
Peptide:
AEFHRWSSYMVHWA
Length:
14
Classification:
Non-amyloid
Mutation(s):
K14A
Structure(s):
No structures
Protein Information
UniProt ID:
P22303
UniProt Name:
ACES_HUMAN
Protein Name:
Acetylcholinesterase (AChE)
Position:
586-599
Literature
PMID:
18350169
Reference:
PLoS One. 2008 Mar 19;3(3):e1834
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
57.14
NuAPRpred:
-0.87
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.9
Area of the profile Above Threshold (AGGRESCAN):
3.3
Best Energy Score (PASTA 2.0):
-3.92
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1752 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
Q
C
L
L
H
T
P
S
L
A
S
P
L
L
L
L
L
L
W
L
L
G
G
G
V
G
A
E
G
R
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
G
I
R
L
K
T
P
G
G
P
V
60
61
S
A
F
L
G
I
P
F
A
E
P
P
M
G
P
R
R
F
L
P
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
M
W
N
P
N
120
121
R
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
G
G
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
A
E
R
T
V
L
V
S
M
180
181
N
Y
R
V
G
A
F
G
F
L
A
L
P
G
S
R
E
A
P
G
N
V
G
L
L
D
Q
R
L
A
L
Q
W
V
Q
E
N
V
A
A
F
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
A
A
S
V
240
241
G
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
P
P
G
G
T
G
G
N
D
T
E
L
300
301
V
A
C
L
R
T
R
P
A
Q
V
L
V
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
P
V
V
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
G
D
F
H
G
L
Q
V
L
V
G
360
361
V
V
K
D
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
P
E
420
421
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
V
C
P
V
A
Q
L
A
G
R
L
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
P
H
G
Y
480
481
E
I
E
F
I
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
G
D
P
N
E
P
R
D
P
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
540
541
Y
V
S
L
D
L
R
P
L
E
V
R
R
G
L
R
A
Q
A
C
A
F
W
N
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
W
K
A
E
F
H
R
W
S
S
Y
M
V
H
W
K
N
600
601
Q
F
D
H
Y
S
K
Q
D
R
C
S
D
L
614
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1752
Peptide:
AEFHRWSSYMVHWK
Length:
14
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P22303
UniProt Name:
ACES_HUMAN
Protein Name:
Acetylcholinesterase (AChE)
Position:
586-599
Literature
PMID:
12427014
Reference:
Biochemistry. 2002 Nov 19;41(46):13539-47.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-1.02
Tango:
13.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.1
Area of the profile Above Threshold (AGGRESCAN):
2.89
Best Energy Score (PASTA 2.0):
-4.33
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1753 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
P
P
Q
C
L
L
H
T
P
S
L
A
S
P
L
L
L
L
L
L
W
L
L
G
G
G
V
G
A
E
G
R
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
G
I
R
L
K
T
P
G
G
P
V
60
61
S
A
F
L
G
I
P
F
A
E
P
P
M
G
P
R
R
F
L
P
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
M
W
N
P
N
120
121
R
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
G
G
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
A
E
R
T
V
L
V
S
M
180
181
N
Y
R
V
G
A
F
G
F
L
A
L
P
G
S
R
E
A
P
G
N
V
G
L
L
D
Q
R
L
A
L
Q
W
V
Q
E
N
V
A
A
F
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
A
A
S
V
240
241
G
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
C
P
P
G
G
T
G
G
N
D
T
E
L
300
301
V
A
C
L
R
T
R
P
A
Q
V
L
V
N
H
E
W
H
V
L
P
Q
E
S
V
F
R
F
S
F
V
P
V
V
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
G
D
F
H
G
L
Q
V
L
V
G
360
361
V
V
K
D
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
V
R
V
G
V
P
Q
V
S
D
L
A
A
E
A
V
V
L
H
Y
T
D
W
L
H
P
E
420
421
D
P
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
V
V
C
P
V
A
Q
L
A
G
R
L
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
P
H
G
Y
480
481
E
I
E
F
I
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
G
D
P
N
E
P
R
D
P
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
540
541
Y
V
S
L
D
L
R
P
L
E
V
R
R
G
L
R
A
Q
A
C
A
F
W
N
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
W
K
A
E
F
H
R
W
S
S
Y
M
V
H
W
K
N
600
601
Q
F
D
H
Y
S
K
Q
D
R
C
S
D
L
614
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1753
Peptide:
AEFHRWSSYMVYWK
Length:
14
Classification:
Amyloid
Mutation(s):
H597Y
Structure(s):
No structures
Protein Information
UniProt ID:
P22303
UniProt Name:
ACES_HUMAN
Protein Name:
Acetylcholinesterase (AChE)
Position:
586-599
Literature
PMID:
12427014
Reference:
Biochemistry. 2002 Nov 19;41(46):13539-47.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
57.14
NuAPRpred:
-0.3
Tango:
490.99
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
20.7
Area of the profile Above Threshold (AGGRESCAN):
4.96
Best Energy Score (PASTA 2.0):
-3.95
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1754 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1754
Peptide:
AVVGGLGGYMLGSA
Length:
14
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
120-133
Literature
PMID:
9405147
Reference:
J Mol Biol. 1997 Dec 5;274(3):381-93.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
57.14
NuAPRpred:
-0.61
Tango:
2.59
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.4
Area of the profile Above Threshold (AGGRESCAN):
4.54
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1755 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1755
Peptide:
DCVNITIKQHTVTT
Length:
14
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
178-191
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
35.71
NuAPRpred:
0.7
Tango:
25.26
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-1.4
Area of the profile Above Threshold (AGGRESCAN):
2.15
Best Energy Score (PASTA 2.0):
-6.08
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1756 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
T
I
Q
H
P
W
F
K
R
T
L
G
P
F
Y
P
S
R
L
F
D
Q
F
F
G
E
G
L
F
E
Y
D
L
L
P
F
L
S
S
T
I
S
P
Y
Y
R
Q
S
L
F
R
T
V
L
D
S
G
60
61
I
S
E
V
R
S
D
R
D
K
F
V
I
F
L
D
V
K
H
F
S
P
E
D
L
T
V
K
V
Q
D
D
F
V
E
I
H
G
K
H
N
E
R
Q
D
D
H
G
Y
I
S
R
E
F
H
R
R
Y
R
L
120
121
P
S
N
V
D
Q
S
A
L
S
C
S
L
S
A
D
G
M
L
T
F
C
G
P
K
I
Q
T
G
L
D
A
T
H
A
E
R
A
I
P
V
S
R
E
E
K
P
T
S
A
P
S
S
173
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1756
Peptide:
DFVIFLDVKHFSPE
Length:
14
Classification:
Amyloid
Mutation(s):
K70D
Structure(s):
No structures
Protein Information
UniProt ID:
P02489
UniProt Name:
CRYAA_HUMAN
Protein Name:
Alpha-crystallin A chain (Heat shock protein beta-4) (HspB4)
Position:
70-83
Literature
PMID:
18232642
Reference:
Biochemistry. 2008 Mar 4;47(9):2961-7.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
57.14
NuAPRpred:
0.59
Tango:
506.69
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.0
Area of the profile Above Threshold (AGGRESCAN):
6.2
Best Energy Score (PASTA 2.0):
-7.03
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1757 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1757
Peptide:
DNNNSANYQVSTSK
Length:
14
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
synthetic
UniProt Name:
Protein Name:
Position:
Literature
PMID:
18952064
Reference:
Biochem Biophys Res Commun. 2008 Dec 19;377(3):966-70.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
21.43
NuAPRpred:
-2.98
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-53.6
Area of the profile Above Threshold (AGGRESCAN):
0.3
Best Energy Score (PASTA 2.0):
-1.11
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1758 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
M
S
R
L
C
L
S
V
A
L
L
V
L
L
G
T
L
A
A
S
T
P
G
C
D
T
S
N
Q
A
K
A
Q
R
P
D
F
C
L
E
P
P
Y
T
G
P
C
K
A
R
I
I
R
Y
F
Y
N
A
60
61
K
A
G
L
C
Q
T
F
V
Y
G
G
C
R
A
K
R
N
N
F
K
S
A
E
D
C
M
R
T
C
G
G
A
I
G
P
W
E
N
L
100
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1758
Peptide:
FKSAEDSMRTSGGA
Length:
14
Classification:
Non-amyloid
Mutation(s):
C86S, C90S
Structure(s):
No structures
Protein Information
UniProt ID:
P00974
UniProt Name:
BPT1_BOVIN
Protein Name:
Pancreatic trypsin inhibitor (Aprotinin)
Position:
80-93
Literature
PMID:
7504737
Reference:
J Mol Biol. 1993 Dec 5;234(3):861-78.
source:
AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
4
Hydrophobicity:
28.57
NuAPRpred:
-5.18
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-46.3
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
0.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1759 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
N
V
P
H
K
S
S
L
P
E
G
I
R
P
G
T
V
L
R
I
R
G
L
V
P
P
N
A
S
R
F
H
V
N
L
L
C
G
E
E
Q
G
S
D
A
A
L
H
F
N
P
R
L
D
T
S
E
V
60
61
V
F
N
S
K
E
Q
G
S
W
G
R
E
E
R
G
P
G
V
P
F
Q
R
G
Q
P
F
E
V
L
I
I
A
S
D
D
G
F
K
A
V
V
G
D
A
Q
Y
H
H
F
R
H
R
L
P
L
A
R
V
R
120
121
L
V
E
V
G
G
D
V
Q
L
D
S
V
R
I
F
136
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1759
Peptide:
LVEVGGDVQLDSVR
Length:
14
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P47929
UniProt Name:
LEG7_HUMAN
Protein Name:
Galectin-7
Position:
121-134
Literature
PMID:
25172508
Reference:
J Biol Chem. 2014 Oct 17;289(42):29195-207
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
42.86
NuAPRpred:
-1.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-11.5
Area of the profile Above Threshold (AGGRESCAN):
1.6
Best Energy Score (PASTA 2.0):
-2.14
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1760 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1760
Peptide:
MKHMAGAAAAGAVV
Length:
14
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
109-122
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
71.43
NuAPRpred:
-2.19
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.7
Area of the profile Above Threshold (AGGRESCAN):
1.47
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1761 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1761
Peptide:
RVEKVAILGLMVLA
Length:
14
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
71.43
NuAPRpred:
4.97
Tango:
870.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
44.9
Area of the profile Above Threshold (AGGRESCAN):
8.04
Best Energy Score (PASTA 2.0):
-6.59
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1762 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1762
Peptide:
SFFSFLGEAFDGAR
Length:
14
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
7672107
Reference:
FEBS Lett. 1995 Sep 4;371(2):110-4.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
-0.11
Tango:
369.34
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.7
Area of the profile Above Threshold (AGGRESCAN):
4.47
Best Energy Score (PASTA 2.0):
-2.76
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1763 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
E
D
S
M
D
M
D
M
S
P
L
R
P
Q
N
Y
L
F
G
C
E
L
K
A
D
K
D
Y
H
F
K
V
D
N
D
E
N
E
H
Q
L
S
L
R
T
V
S
L
G
A
G
A
K
D
E
L
H
I
V
60
61
E
A
E
A
M
N
Y
E
G
S
P
I
K
V
T
L
A
T
L
K
M
S
V
Q
P
T
V
S
L
G
G
F
E
I
T
P
P
V
V
L
R
L
K
C
G
S
G
P
V
H
I
S
G
Q
H
L
V
A
V
E
120
121
E
D
A
E
S
E
D
E
E
E
E
D
V
K
L
L
S
I
S
G
K
R
S
A
P
G
G
G
S
K
V
P
Q
K
K
V
K
L
A
A
D
E
D
D
D
D
D
D
E
E
D
D
D
E
D
D
D
D
D
D
180
181
F
D
D
E
E
A
E
E
K
A
P
V
K
K
S
I
R
D
T
P
A
K
N
A
Q
K
S
N
Q
N
G
K
D
S
K
P
S
S
T
P
R
S
K
G
Q
E
S
F
K
K
Q
E
K
T
P
K
T
P
K
G
240
241
P
S
S
V
E
D
I
K
A
K
M
Q
A
S
I
E
K
G
G
S
L
P
K
V
E
A
K
F
I
N
Y
V
K
N
C
F
R
M
T
D
Q
E
A
I
Q
D
L
W
Q
W
R
K
S
L
294
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1763
Peptide:
VEAKFINYVKNCFR
Length:
14
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P06748
UniProt Name:
NPM_HUMAN
Protein Name:
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23)
Position:
264-277
Literature
PMID:
25977257
Reference:
FASEB J. 2015 Sep;29(9):3689-701.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
57.14
NuAPRpred:
3.09
Tango:
15.91
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.9
Area of the profile Above Threshold (AGGRESCAN):
3.4
Best Energy Score (PASTA 2.0):
-5.28
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1764 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
N
I
R
P
L
H
D
R
V
I
V
K
R
K
E
V
E
T
K
S
A
G
G
I
V
L
T
G
S
A
A
A
K
S
T
R
G
E
V
L
A
V
G
N
G
R
I
L
E
N
G
E
V
K
P
L
D
V
K
60
61
V
G
D
I
V
I
F
N
D
G
Y
G
V
K
S
E
K
I
D
N
E
E
V
L
I
M
S
E
S
D
I
L
A
I
V
E
A
97
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1764
Peptide:
VGDIVIFNDGYGVK
Length:
14
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P0A6F9
UniProt Name:
CH10_ECOLI
Protein Name:
chaperonin (GroES protein) (Protein Cpn10)
Position:
61-74
Literature
PMID:
18329043
Reference:
J Mol Biol. 2008 Apr 11;377(5):1593-606.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
50.0
NuAPRpred:
0.88
Tango:
44.47
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
20.5
Area of the profile Above Threshold (AGGRESCAN):
4.07
Best Energy Score (PASTA 2.0):
-6.84
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1765 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1765
Peptide:
VNITIKQHTVTTTT
Length:
14
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
180-193
Literature
PMID:
11020222
Reference:
J Neurosci Res. 2000 Oct 15;62(2):293-301.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
28.57
NuAPRpred:
-1.33
Tango:
0.62
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.3
Area of the profile Above Threshold (AGGRESCAN):
2.01
Best Energy Score (PASTA 2.0):
-6.01
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1766 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
N
L
G
C
W
M
L
V
L
F
V
A
T
W
S
D
L
G
L
C
K
K
R
P
K
P
G
G
W
N
T
G
G
S
R
Y
P
G
Q
G
S
P
G
G
N
R
Y
P
P
Q
G
G
G
G
W
G
Q
P
60
61
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
P
H
G
G
G
W
G
Q
G
G
G
T
H
S
Q
W
N
K
P
S
K
P
K
T
N
M
K
H
M
A
G
A
A
A
A
G
A
120
121
V
V
G
G
L
G
G
Y
M
L
G
S
A
M
S
R
P
I
I
H
F
G
S
D
Y
E
D
R
Y
Y
R
E
N
M
H
R
Y
P
N
Q
V
Y
Y
R
P
M
D
E
Y
S
N
Q
N
N
F
V
H
D
C
V
180
181
N
I
T
I
K
Q
H
T
V
T
T
T
T
K
G
E
N
F
T
E
T
D
V
K
M
M
E
R
V
V
E
Q
M
C
I
T
Q
Y
E
R
E
S
Q
A
Y
Y
Q
R
G
S
S
M
V
L
F
S
S
P
P
V
240
241
I
L
L
I
S
F
L
I
F
L
I
V
G
253
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1766
Peptide:
AGAAAAGAVVGGLGG
Length:
15
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P04156
UniProt Name:
PRIO_HUMAN
Protein Name:
Major prion protein (PrP)
Position:
113-127
Literature
PMID:
16537487
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4074-8.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
60.0
NuAPRpred:
1.06
Tango:
12.06
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
2.6
Area of the profile Above Threshold (AGGRESCAN):
2.63
Best Energy Score (PASTA 2.0):
-2.17
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1767 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
A
D
K
E
L
K
F
L
V
V
D
D
F
S
T
M
R
R
I
V
R
N
L
L
K
E
L
G
F
N
N
V
E
E
A
E
D
G
L
D
A
L
N
K
L
Q
A
G
G
Y
G
F
V
I
S
D
W
N
M
60
61
P
N
M
D
G
L
E
L
L
K
T
I
R
A
D
G
A
M
S
A
L
P
V
L
M
V
T
A
E
A
K
K
E
N
I
I
A
A
A
Q
A
G
A
S
G
Y
V
V
K
P
F
T
A
A
T
L
E
E
K
L
120
121
N
K
I
F
E
K
L
G
M
129
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1767
Peptide:
EDGVDALNKLQAGGY
Length:
15
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
Q93P00
UniProt Name:
CHEY_ECOL6
Protein Name:
Chemotaxis protein CheY
Position:
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
40.0
NuAPRpred:
-3.36
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-32.7
Area of the profile Above Threshold (AGGRESCAN):
0.25
Best Energy Score (PASTA 2.0):
-0.77
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1768 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
K
I
L
V
I
D
D
H
P
A
V
M
E
G
T
K
T
I
L
E
T
D
S
N
L
S
V
D
C
L
S
P
E
P
S
E
Q
F
I
K
Q
H
D
F
S
S
Y
D
L
I
L
M
D
L
N
L
G
G
60
61
E
V
N
G
M
E
L
S
K
Q
I
L
Q
E
N
P
H
C
K
I
I
V
Y
T
G
Y
E
V
E
D
Y
F
E
E
A
I
R
A
G
L
H
G
A
I
S
K
T
E
S
K
E
K
I
T
Q
Y
I
Y
H
V
120
121
L
N
G
E
I
L
V
D
F
A
Y
F
K
Q
L
M
T
Q
Q
K
T
K
P
A
P
S
S
Q
K
E
Q
D
V
L
T
P
R
E
C
L
I
L
Q
E
V
E
K
G
F
T
N
Q
E
I
A
D
A
L
H
L
180
181
S
K
R
S
I
E
Y
S
L
T
S
I
F
N
K
L
N
V
G
S
R
T
E
A
V
L
I
A
K
S
D
G
V
L
214
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1768
Peptide:
EPSEQFIKQHDFSSY
Length:
15
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14204
UniProt Name:
CMPA_BACSU
Protein Name:
Transcriptional regulatory protein ComA (Competence protein A)
Position:
35-49
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
33.33
NuAPRpred:
-3.23
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.7
Area of the profile Above Threshold (AGGRESCAN):
0.98
Best Energy Score (PASTA 2.0):
-1.26
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1769 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
K
I
L
V
I
D
D
H
P
A
V
M
E
G
T
K
T
I
L
E
T
D
S
N
L
S
V
D
C
L
S
P
E
P
S
E
Q
F
I
K
Q
H
D
F
S
S
Y
D
L
I
L
M
D
L
N
L
G
G
60
61
E
V
N
G
M
E
L
S
K
Q
I
L
Q
E
N
P
H
C
K
I
I
V
Y
T
G
Y
E
V
E
D
Y
F
E
E
A
I
R
A
G
L
H
G
A
I
S
K
T
E
S
K
E
K
I
T
Q
Y
I
Y
H
V
120
121
L
N
G
E
I
L
V
D
F
A
Y
F
K
Q
L
M
T
Q
Q
K
T
K
P
A
P
S
S
Q
K
E
Q
D
V
L
T
P
R
E
C
L
I
L
Q
E
V
E
K
G
F
T
N
Q
E
I
A
D
A
L
H
L
180
181
S
K
R
S
I
E
Y
S
L
T
S
I
F
N
K
L
N
V
G
S
R
T
E
A
V
L
I
A
K
S
D
G
V
L
214
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1769
Peptide:
EVEDYFEEAIRAGLH
Length:
15
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P14204
UniProt Name:
CMPA_BACSU
Protein Name:
Transcriptional regulatory protein ComA (Competence protein A)
Position:
87-101
Literature
PMID:
8520484
Reference:
Protein Sci. 1995 Aug;4(8):1577-86.
source:
AmyLoad
Derived Information
Net Charge:
-4
Absolute Charge:
6
Hydrophobicity:
46.67
NuAPRpred:
-2.79
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-24.9
Area of the profile Above Threshold (AGGRESCAN):
0.78
Best Energy Score (PASTA 2.0):
-0.86
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1770 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
L
P
G
L
A
L
L
L
L
A
A
W
T
A
R
A
L
E
V
P
T
D
G
N
A
G
L
L
A
E
P
Q
I
A
M
F
C
G
R
L
N
M
H
M
N
V
Q
N
G
K
W
D
S
D
P
S
G
T
K
60
61
T
C
I
D
T
K
E
G
I
L
Q
Y
C
Q
E
V
Y
P
E
L
Q
I
T
N
V
V
E
A
N
Q
P
V
T
I
Q
N
W
C
K
R
G
R
K
Q
C
K
T
H
P
H
F
V
I
P
Y
R
C
L
V
G
120
121
E
F
V
S
D
A
L
L
V
P
D
K
C
K
F
L
H
Q
E
R
M
D
V
C
E
T
H
L
H
W
H
T
V
A
K
E
T
C
S
E
K
S
T
N
L
H
D
Y
G
M
L
L
P
C
G
I
D
K
F
R
180
181
G
V
E
F
V
C
C
P
L
A
E
E
S
D
N
V
D
S
A
D
A
E
E
D
D
S
D
V
W
W
G
G
A
D
T
D
Y
A
D
G
S
E
D
K
V
V
E
V
A
E
E
E
E
V
A
E
V
E
E
E
240
241
E
A
D
D
D
E
D
D
E
D
G
D
E
V
E
E
E
A
E
E
P
Y
E
E
A
T
E
R
T
T
S
I
A
T
T
T
T
T
T
T
E
S
V
E
E
V
V
R
E
V
C
S
E
Q
A
E
T
G
P
C
300
301
R
A
M
I
S
R
W
Y
F
D
V
T
E
G
K
C
A
P
F
F
Y
G
G
C
G
G
N
R
N
N
F
D
T
E
E
Y
C
M
A
V
C
G
S
A
M
S
Q
S
L
L
K
T
T
Q
E
P
L
A
R
D
360
361
P
V
K
L
P
T
T
A
A
S
T
P
D
A
V
D
K
Y
L
E
T
P
G
D
E
N
E
H
A
H
F
Q
K
A
K
E
R
L
E
A
K
H
R
E
R
M
S
Q
V
M
R
E
W
E
E
A
E
R
Q
A
420
421
K
N
L
P
K
A
D
K
K
A
V
I
Q
H
F
Q
E
K
V
E
S
L
E
Q
E
A
A
N
E
R
Q
Q
L
V
E
T
H
M
A
R
V
E
A
M
L
N
D
R
R
R
L
A
L
E
N
Y
I
T
A
L
480
481
Q
A
V
P
P
R
P
R
H
V
F
N
M
L
K
K
Y
V
R
A
E
Q
K
D
R
Q
H
T
L
K
H
F
E
H
V
R
M
V
D
P
K
K
A
A
Q
I
R
S
Q
V
M
T
H
L
R
V
I
Y
E
R
540
541
M
N
Q
S
L
S
L
L
Y
N
V
P
A
V
A
E
E
I
Q
D
E
V
D
E
L
L
Q
K
E
Q
N
Y
S
D
D
V
L
A
N
M
I
S
E
P
R
I
S
Y
G
N
D
A
L
M
P
S
L
T
E
T
600
601
K
T
T
V
E
L
L
P
V
N
G
E
F
S
L
D
D
L
Q
P
W
H
S
F
G
A
D
S
V
P
A
N
T
E
N
E
V
E
P
V
D
A
R
P
A
A
D
R
G
L
T
T
R
P
G
S
G
L
T
N
660
661
I
K
T
E
E
I
S
E
V
K
M
D
A
E
F
R
H
D
S
G
Y
E
V
H
H
Q
K
L
V
F
F
A
E
D
V
G
S
N
K
G
A
I
I
G
L
M
V
G
G
V
V
I
A
T
V
I
V
I
T
L
720
721
V
M
L
K
K
K
Q
Y
T
S
I
H
H
G
V
V
E
V
D
A
A
V
T
P
E
E
R
H
L
S
K
M
Q
Q
N
G
Y
E
N
P
T
Y
K
F
F
E
Q
M
Q
N
770
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1770
Peptide:
EVHHQKLVFFAEDVG
Length:
15
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P05067
UniProt Name:
A4_HUMAN
Protein Name:
Amyloid-beta precursor protein (APP)
Position:
682-696
Literature
PMID:
7827029
1
Reference:
Biochemistry. 1995 Jan 24;34(3):724-30., J Biol Chem. 2002 Nov 8;277(45):43243-6.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
4
Hydrophobicity:
46.67
NuAPRpred:
1.92
Tango:
433.22
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-8.1
Area of the profile Above Threshold (AGGRESCAN):
3.82
Best Energy Score (PASTA 2.0):
-4.54
Aggregate Orientation (PASTA 2.0):
Parallel
