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APR Prediction Models
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
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Tutorial
Statistics
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APR Prediction Models:
GAP (Generalized Aggregation Proneness)
ANuPP (Prediciton of Nucleating APRs)
V
L
AmY-Pred (Predicting antibody light chain aggregation)
Aggregation Kinetics Prediction Models:
AggreRATE-Disc (Classifying Aggregating Point Mutation)
AggreRATE-Pred (Predicting Aggregation Rate for Point Mutation)
AbsoluRATE (Predicting Absolute aggregation rate)
Amylo-Pipe (Comprehensive aggregation prediction)
Database of known aggregating/non-aggregating peptides
Select a Field to filter:
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Peptide Sequence
Protein Name
Entry ID
Peptide length
PMID
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Displaying 1711 to 1740 records out of 2031 records fetched.
Entry
Peptide
Length
Class
Protein Name
UniProt ID
Mutant
Reference
PMID
Source Database
P-1711
GQQQQQQQQQQG
12
Amyloid
Ribonuclease (RNase A)
P61823
Adv Protein Chem. 2006;73:235-82.
17190616
CPAD
P-1712
IPAGVDAVKISM
12
Amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):795-817.
1507227
CPAD, AmyLoad
P-1713
KFFEAAAKKFFE
12
Amyloid
Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20.
15630094
CPAD
P-1714
KGKKGEIKNVAD
12
Non-amyloid
50S ribosomal protein L9 (BL17)
P02417
No
J Mol Biol. 1999 Mar 26;287(2):395-407.
10080901
AmyLoad
P-1715
KIVFKNNAGFPH
12
Non-amyloid
Plastocyanin
P00287
No
J Mol Biol. 1992 Aug 5;226(3):819-35.
1507228
AmyLoad
P-1716
LKNVKSKIGSTE
12
Non-amyloid
Microtubule-associated protein tau (PHF-tau)
P10636
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
10805776
AmyLoad
P-1717
LSNIDYILIKAS
12
Amyloid
Laminin subunit alpha-1 (Laminin A chain)
P19137
No
Biochemistry. 2007 Apr 3;46(13):3966-74.
17348688
CPAD
P-1718
NFGAILSSTNVG
12
Amyloid
Islet amyloid polypeptide (Amylin)
P10997
No
Nature. 2007 May 24;447(7143):453-7.
17468747
CPAD
P-1719
PLLSAYVARLSA
12
Non-amyloid
Glutathione S-transferase P
P80031
No
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
11370666
AmyLoad
P-1720
SAKVDAIGLEIV
12
Amyloid
Laminin subunit alpha-1 (Laminin A chain)
P19137
No
Biochemistry. 2007 Apr 3;46(13):3966-74.
17348688
CPAD
P-1721
SLVCQCLVRTPW
12
Amyloid
Beta-lactoglobulin (Beta-LG)
P02755
A136V, E145W
J Mol Biol. 2009 Feb 27;386(3):878-90.
19133274
CPAD
P-1722
VILQQSAADIAR
12
Amyloid
Laminin subunit beta-1 (Laminin B1 chain)
P02469
No
Biochemistry. 2007 Apr 3;46(13):3966-74.
17348688
CPAD
P-1723
VTGVTAVAQKTV
12
Amyloid
Alpha-synuclein
P37840
No
J Biol Chem. 2001 Jan 26;276(4):2380-6.
11060312
CPAD
P-1724
VTVKVDAVKVTV
12
Amyloid
J Mol Biol. 1999 Jun 4;289(2):413-28.
10366514
CPAD
P-1725
VTVKVEAVKVTV
12
Amyloid
J Mol Biol. 1999 Jun 4;289(2):413-28.
10366514
CPAD
P-1726
VTVKVNAVKVTV
12
Amyloid
J Mol Biol. 1999 Jun 4;289(2):413-28.
10366514
CPAD, AmyLoad
P-1727
WQQVLNVWGKVE
12
Amyloid
Biophys J. 2007 Dec 15;93(12):4382-91.
17766358
CPAD
P-1728
ARIIRYFYNAKAG
13
Non-amyloid
Pancreatic trypsin inhibitor (Aprotinin)
P00974
No
J Mol Biol. 1993 Dec 5;234(3):861-78.
7504737
AmyLoad
P-1729
ATQRLANFLVHSS
13
Amyloid
J Struct Biol. 2003 Mar;141(3):218-27.
12648568
CPAD, AmyLoad
P-1730
DWSFYLLYYTEFT
13
Amyloid
Beta-2-microglobulin
P61769
No
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4079-82.
16537488
CPAD, AmyLoad
P-1731
DYFLFRDGDILGK
13
Amyloid
heat shock protein, mitochondrial (Hsp10)
P26772
No
J Mol Biol. 2008 Apr 11;377(5):1593-606.
18329043
CPAD
P-1732
EDVAVYYCHQYYS
13
Amyloid
J Struct Biol. 2005 Sep;151(3):229-38.
16125973
CPAD
P-1733
EQVTNVGGAVVTG
13
Amyloid
Alpha-synuclein
P37840
No
Eur J Biochem. 2000 Apr;267(8):2186-94.
10759841
CPAD, AmyLoad
P-1734
ISKLEYSNFSVRY
13
Amyloid
Acylphosphatase-2
P14621
I97V
Nat Struct Biol. 2002 Feb;9(2):137-43.
11799398
CPAD, AmyLoad
P-1735
KLKLKLELELELG
13
Amyloid
Biochem Biophys Res Commun. 1997 Jun 27;235(3):675-9.
9207218
CPAD
P-1736
LDNWDSVTSTFSK
13
Amyloid
Apolipoprotein A-I
P02647
No
Biochemistry. 2016 Dec 19
27992182
CPAD
P-1737
LGVVGSTTTQLYT
13
Amyloid
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3)
Q15582
No
Eur J Biochem. 2002 Nov;269(21):5149-56.
12392546
CPAD
P-1738
LSQPKIVKWDRDM
13
Non-amyloid
Beta-2-microglobulin
P61769
No
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
12488093
AmyLoad
P-1739
NGKSNFLNCYVSG
13
Non-amyloid
Beta-2-microglobulin
P61769
No
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
12488093
AmyLoad
P-1740
NHAIVQTLVNSVN
13
Amyloid
Bone morphogenetic protein 2 (BMP-2)
P12643
No
PLoS Biol. 2008 Aug 5;6(8):e195.
18684013
CPAD
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Entry: P-1711 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1711
Peptide:
GQQQQQQQQQQG
Length:
12
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P61823
UniProt Name:
RNAS1_BOVIN
Protein Name:
Ribonuclease (RNase A)
Position:
Literature
PMID:
17190616
Reference:
Adv Protein Chem. 2006;73:235-82.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
0.0
NuAPRpred:
-1.0
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-117.0
Area of the profile Above Threshold (AGGRESCAN):
0.0
Best Energy Score (PASTA 2.0):
1.1
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1712 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1712
Peptide:
IPAGVDAVKISM
Length:
12
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
46-57
Literature
PMID:
1507227
Reference:
J Mol Biol. 1992 Aug 5;226(3):795-817.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
66.67
NuAPRpred:
-1.17
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
11.6
Area of the profile Above Threshold (AGGRESCAN):
2.24
Best Energy Score (PASTA 2.0):
-2.65
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1713 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1713
Peptide:
KFFEAAAKKFFE
Length:
12
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
15630094
Reference:
Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):315-20.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
58.33
NuAPRpred:
-2.34
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.2
Area of the profile Above Threshold (AGGRESCAN):
1.22
Best Energy Score (PASTA 2.0):
-2.22
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1714 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
V
I
F
L
K
D
V
K
G
K
G
K
K
G
E
I
K
N
V
A
D
G
Y
A
N
N
F
L
F
K
Q
G
L
A
I
E
A
T
P
A
N
L
K
A
L
E
A
Q
K
Q
K
E
Q
R
Q
A
A
E
60
61
E
L
A
N
A
K
K
L
K
E
Q
L
E
K
L
T
V
T
I
P
A
K
A
G
E
G
G
R
L
F
G
S
I
T
S
K
Q
I
A
E
S
L
Q
A
Q
H
G
L
K
L
D
K
R
K
I
E
L
A
D
A
120
121
I
R
A
L
G
Y
T
N
V
P
V
K
L
H
P
E
V
T
A
T
L
K
V
H
V
T
E
Q
K
149
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1714
Peptide:
KGKKGEIKNVAD
Length:
12
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02417
UniProt Name:
RL9_GEOSE
Protein Name:
50S ribosomal protein L9 (BL17)
Position:
12-23
Literature
PMID:
10080901
Reference:
J Mol Biol. 1999 Mar 26;287(2):395-407.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
6
Hydrophobicity:
25.0
NuAPRpred:
-0.65
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-52.3
Area of the profile Above Threshold (AGGRESCAN):
0.25
Best Energy Score (PASTA 2.0):
-2.62
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1715 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
L
E
V
L
L
G
S
G
D
G
S
L
V
F
V
P
S
E
F
S
V
P
S
G
E
K
I
V
F
K
N
N
A
G
F
P
H
N
V
V
F
D
E
D
E
I
P
A
G
V
D
A
V
K
I
S
M
P
E
E
60
61
E
L
L
N
A
P
G
E
T
Y
V
V
T
L
D
T
K
G
T
Y
S
F
Y
C
S
P
H
Q
G
A
G
M
V
G
K
V
T
V
N
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1715
Peptide:
KIVFKNNAGFPH
Length:
12
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00287
UniProt Name:
PLAS_PHAVU
Protein Name:
Plastocyanin
Position:
26-37
Literature
PMID:
1507228
Reference:
J Mol Biol. 1992 Aug 5;226(3):819-35.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
-1.71
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.4
Area of the profile Above Threshold (AGGRESCAN):
2.65
Best Energy Score (PASTA 2.0):
-3.53
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1716 Classification: Non-amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1716
Peptide:
LKNVKSKIGSTE
Length:
12
Classification:
Non-amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
P10636
UniProt Name:
TAU_HUMAN
Protein Name:
Microtubule-associated protein tau (PHF-tau)
Position:
Literature
PMID:
10805776
Reference:
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5129-34.
source:
AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
4
Hydrophobicity:
25.0
NuAPRpred:
-1.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-22.0
Area of the profile Above Threshold (AGGRESCAN):
0.27
Best Energy Score (PASTA 2.0):
-1.4
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1717 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
G
S
G
T
G
A
A
L
L
V
L
L
A
S
V
L
W
V
T
V
R
S
Q
Q
R
G
L
F
P
A
I
L
N
L
A
T
N
A
H
I
S
A
N
A
T
C
G
E
K
G
P
E
M
F
C
K
L
V
60
61
E
H
V
P
G
R
P
V
R
H
A
Q
C
R
V
C
D
G
N
S
T
N
P
R
E
R
H
P
I
S
H
A
I
D
G
T
N
N
W
W
Q
S
P
S
I
Q
N
G
R
E
Y
H
W
V
T
V
T
L
D
L
120
121
R
Q
V
F
Q
V
A
Y
I
I
I
K
A
A
N
A
P
R
P
G
N
W
I
L
E
R
S
V
D
G
V
K
F
K
P
W
Q
Y
Y
A
V
S
D
T
E
C
L
T
R
Y
K
I
T
P
R
R
G
P
P
T
180
181
Y
R
A
D
N
E
V
I
C
T
S
Y
Y
S
K
L
V
P
L
E
H
G
E
I
H
T
S
L
I
N
G
R
P
S
A
D
D
P
S
P
Q
L
L
E
F
T
S
A
R
Y
I
R
L
R
L
Q
R
I
R
T
240
241
L
N
A
D
L
M
T
L
S
H
R
D
L
R
D
L
D
P
I
V
T
R
R
Y
Y
Y
S
I
K
D
I
S
V
G
G
M
C
I
C
Y
G
H
A
S
S
C
P
W
D
E
E
A
K
Q
L
Q
C
Q
C
E
300
301
H
N
T
C
G
E
S
C
D
R
C
C
P
G
Y
H
Q
Q
P
W
R
P
G
T
I
S
S
G
N
E
C
E
E
C
N
C
H
N
K
A
K
D
C
Y
Y
D
S
S
V
A
K
E
R
R
S
L
N
T
A
G
360
361
Q
Y
S
G
G
G
V
C
V
N
C
S
Q
N
T
T
G
I
N
C
E
T
C
I
D
Q
Y
Y
R
P
H
K
V
S
P
Y
D
D
H
P
C
R
P
C
N
C
D
P
V
G
S
L
S
S
V
C
I
K
D
D
420
421
R
H
A
D
L
A
N
G
K
W
P
G
Q
C
P
C
R
K
G
Y
A
G
D
K
C
D
R
C
Q
F
G
Y
R
G
F
P
N
C
I
P
C
D
C
R
T
V
G
S
L
N
E
D
P
C
I
E
P
C
L
C
480
481
K
K
N
V
E
G
K
N
C
D
R
C
K
P
G
F
Y
N
L
K
E
R
N
P
E
G
C
S
E
C
F
C
F
G
V
S
G
V
C
D
S
L
T
W
S
I
S
Q
V
T
N
M
S
G
W
L
V
T
D
L
540
541
M
S
T
N
K
I
R
S
Q
Q
D
V
L
G
G
H
R
Q
I
S
I
N
N
T
A
V
M
Q
R
L
T
S
T
Y
Y
W
A
A
P
E
A
Y
L
G
N
K
L
T
A
F
G
G
F
L
K
Y
T
V
S
Y
600
601
D
I
P
V
E
T
V
D
S
D
L
M
S
H
A
D
I
I
I
K
G
N
G
L
T
I
S
T
R
A
E
G
L
S
L
Q
P
Y
E
E
Y
F
N
V
V
R
L
V
P
E
N
F
R
D
F
D
T
R
R
E
660
661
I
D
R
D
Q
L
M
T
V
L
A
N
V
T
H
L
L
I
R
A
N
Y
N
S
A
K
M
A
L
Y
R
L
D
S
V
S
L
D
I
A
S
P
N
A
I
D
L
A
V
A
A
D
V
E
H
C
E
C
P
Q
720
721
G
Y
T
G
T
S
C
E
A
C
L
P
G
Y
Y
R
V
D
G
I
L
F
G
G
I
C
Q
P
C
E
C
H
G
H
A
S
E
C
D
I
H
G
I
C
S
V
C
T
H
N
T
T
G
D
H
C
E
Q
C
L
780
781
P
G
F
Y
G
T
P
S
R
G
T
P
G
D
C
Q
P
C
A
C
P
L
S
I
D
S
N
N
F
S
P
T
C
H
L
T
D
G
E
E
V
V
C
D
Q
C
A
P
G
Y
S
G
S
W
C
E
R
C
A
D
840
841
G
Y
Y
G
N
P
T
V
P
G
G
T
C
V
P
C
N
C
S
G
N
V
D
P
L
E
A
G
H
C
D
S
V
T
G
E
C
L
K
C
L
W
N
T
D
G
A
H
C
E
R
C
A
D
G
F
Y
G
D
A
900
901
V
T
A
K
N
C
R
A
C
D
C
H
E
N
G
S
L
S
G
I
C
H
L
E
T
G
L
C
D
C
K
P
H
V
T
G
Q
Q
C
D
Q
C
L
S
G
Y
Y
G
L
D
T
G
L
G
C
V
P
C
N
C
960
961
S
V
E
G
S
V
S
D
N
C
T
E
E
G
Q
C
H
C
G
P
G
V
S
G
K
Q
C
D
R
C
S
H
G
F
Y
A
F
Q
D
G
G
C
T
P
C
D
C
A
H
T
Q
N
N
C
D
P
A
S
G
E
1020
1021
C
L
C
P
P
H
T
Q
G
L
K
C
E
E
C
E
E
A
Y
W
G
L
D
P
E
Q
G
C
Q
A
C
N
C
S
A
V
G
S
T
S
A
Q
C
D
V
L
S
G
H
C
P
C
K
K
G
F
G
G
Q
S
1080
1081
C
H
Q
C
S
L
G
Y
R
S
F
P
D
C
V
P
C
G
C
D
L
R
G
T
L
P
D
T
C
D
L
E
Q
G
L
C
S
C
S
E
D
G
G
T
C
S
C
K
E
N
A
V
G
P
Q
C
S
K
C
Q
1140
1141
A
G
T
F
A
L
R
G
D
N
P
Q
G
C
S
P
C
F
C
F
G
L
S
Q
L
C
S
E
L
E
G
Y
V
R
T
L
I
T
L
A
S
D
Q
P
L
L
H
V
V
S
Q
S
N
L
K
G
T
I
E
G
1200
1201
V
H
F
Q
P
P
D
T
L
L
D
A
E
A
V
R
Q
H
I
Y
A
E
P
F
Y
W
R
L
P
K
Q
F
Q
G
D
Q
L
L
A
Y
G
G
K
L
Q
Y
S
V
A
F
Y
S
T
L
G
T
G
T
S
N
1260
1261
Y
E
P
Q
V
L
I
K
G
G
R
A
R
K
H
V
I
Y
M
D
A
P
A
P
E
N
G
V
R
Q
D
Y
E
V
R
M
K
E
E
F
W
K
Y
F
N
S
V
S
E
K
H
V
T
H
S
D
F
M
S
V
1320
1321
L
S
N
I
D
Y
I
L
I
K
A
S
Y
G
Q
G
L
Q
Q
S
R
I
A
N
I
S
M
E
V
G
R
K
A
V
E
L
P
A
E
G
E
A
A
L
L
L
E
L
C
V
C
P
P
G
T
A
G
H
S
C
1380
1381
Q
D
C
A
P
G
Y
Y
R
E
K
L
P
E
S
G
G
R
G
P
R
P
L
L
A
P
C
V
P
C
N
C
N
N
H
S
D
V
C
D
P
E
T
G
K
C
L
S
C
R
D
H
T
S
G
D
H
C
E
L
1440
1441
C
A
S
G
Y
Y
G
K
V
T
G
L
P
G
D
C
T
P
C
T
C
P
H
H
P
P
F
S
F
S
P
T
C
V
V
E
G
D
S
D
F
R
C
N
A
C
L
P
G
Y
E
G
Q
Y
C
E
R
C
S
A
1500
1501
G
Y
H
G
N
P
R
A
A
G
G
S
C
Q
T
C
D
C
N
P
Q
G
S
V
H
S
D
C
D
R
A
S
G
Q
C
V
C
K
P
G
A
T
G
L
H
C
E
K
C
L
P
R
H
I
L
M
E
S
D
C
1560
1561
V
S
C
D
D
D
C
V
G
P
L
L
N
D
L
D
S
V
G
D
A
V
L
S
L
N
L
T
G
V
S
P
A
P
Y
G
I
L
E
N
L
E
N
T
T
K
Y
F
Q
R
Y
L
I
K
E
N
A
K
K
I
1620
1621
R
A
E
I
Q
L
E
G
I
A
E
Q
T
E
N
L
Q
K
E
L
T
R
V
L
A
R
H
Q
K
V
N
A
E
M
E
R
T
S
N
G
T
Q
A
L
A
T
F
I
E
Q
L
H
A
N
I
K
E
I
T
E
1680
1681
K
V
A
T
L
N
Q
T
A
R
K
D
F
Q
P
P
V
S
A
L
Q
S
M
H
Q
N
I
S
S
L
L
G
L
I
K
E
R
N
F
T
E
M
Q
Q
N
A
T
L
E
L
K
A
A
K
D
L
L
S
R
I
1740
1741
Q
K
R
F
Q
K
P
Q
E
K
L
K
A
L
K
E
A
N
S
L
L
S
N
H
S
E
K
L
Q
A
A
E
E
L
L
K
E
A
G
S
K
T
Q
E
S
N
L
L
L
L
L
V
K
A
N
L
K
E
F
Q
1800
1801
E
K
K
L
R
V
Q
E
E
Q
N
V
T
S
E
L
I
A
K
G
R
E
W
V
D
A
A
G
T
H
T
A
A
A
Q
D
T
L
T
Q
L
E
H
H
R
D
E
L
L
L
W
A
R
K
I
R
S
H
V
D
1860
1861
D
L
V
M
Q
M
S
K
R
R
A
R
D
L
V
H
R
A
E
Q
H
A
S
E
L
Q
S
R
A
G
A
L
D
R
D
L
E
N
V
R
N
V
S
L
N
A
T
S
A
A
H
V
H
S
N
I
Q
T
L
T
1920
1921
E
E
A
E
M
L
A
A
D
A
H
K
T
A
N
K
T
D
L
I
S
E
S
L
A
S
R
G
K
A
V
L
Q
R
S
S
R
F
L
K
E
S
V
S
T
R
R
K
Q
Q
G
I
T
M
K
L
D
E
L
K
1980
1981
N
L
T
S
Q
F
Q
E
S
M
D
N
I
M
K
Q
A
N
D
S
L
A
M
L
R
E
S
P
G
G
M
R
E
K
G
R
K
A
R
E
L
A
A
A
A
N
E
S
A
V
K
T
L
E
D
V
L
A
L
S
2040
2041
L
R
V
F
N
T
S
E
D
L
S
R
V
N
A
T
V
Q
E
T
N
D
L
L
H
N
S
T
M
T
T
L
L
A
G
R
K
M
K
D
M
E
M
Q
A
N
L
L
L
D
R
L
K
P
L
K
T
L
E
E
2100
2101
N
L
S
R
N
L
S
E
I
K
L
L
I
S
R
A
R
K
Q
V
A
S
I
K
V
A
V
S
A
D
R
D
C
I
R
A
Y
Q
P
Q
T
S
S
T
N
Y
N
T
L
I
L
N
V
K
T
Q
E
P
D
N
2160
2161
L
L
F
Y
L
G
S
S
S
S
S
D
F
L
A
V
E
M
R
R
G
K
V
A
F
L
W
D
L
G
S
G
S
T
R
L
E
F
P
E
V
S
I
N
N
N
R
W
H
S
I
Y
I
T
R
F
G
N
M
G
2220
2221
S
L
S
V
K
E
A
S
A
A
E
N
P
P
V
R
T
S
K
S
P
G
P
S
K
V
L
D
I
N
N
S
T
L
M
F
V
G
G
L
G
G
Q
I
K
K
S
P
A
V
K
V
T
H
F
K
G
C
M
G
2280
2281
E
A
F
L
N
G
K
S
I
G
L
W
N
Y
I
E
R
E
G
K
C
N
G
C
F
G
S
S
Q
N
E
D
S
S
F
H
F
D
G
S
G
Y
A
M
V
E
K
T
L
R
P
T
V
T
Q
I
V
I
L
F
2340
2341
S
T
F
S
P
N
G
L
L
F
Y
L
A
S
N
G
T
K
D
F
L
S
I
E
L
V
R
G
R
V
K
V
M
V
D
L
G
S
G
P
L
T
L
M
T
D
R
R
Y
N
N
G
T
W
Y
K
I
A
F
Q
2400
2401
R
N
R
K
Q
G
L
L
A
V
F
D
A
Y
D
T
S
D
K
E
T
K
Q
G
E
T
P
G
A
A
S
D
L
N
R
L
E
K
D
L
I
Y
V
G
G
L
P
H
S
K
A
V
R
K
G
V
S
S
R
S
2460
2461
Y
V
G
C
I
K
N
L
E
I
S
R
S
T
F
D
L
L
R
N
S
Y
G
V
R
K
G
C
A
L
E
P
I
Q
S
V
S
F
L
R
G
G
Y
V
E
M
P
P
K
S
L
S
P
E
S
S
L
L
A
T
2520
2521
F
A
T
K
N
S
S
G
I
L
L
V
A
L
G
K
D
A
E
E
A
G
G
A
Q
A
H
V
P
F
F
S
I
M
L
L
E
G
R
I
E
V
H
V
N
S
G
D
G
T
S
L
R
K
A
L
L
H
A
P
2580
2581
T
G
S
Y
S
D
G
Q
E
H
S
I
S
L
V
R
N
R
R
V
I
T
I
Q
V
D
E
N
S
P
V
E
M
K
L
G
P
L
T
E
G
K
T
I
D
I
S
N
L
Y
I
G
G
L
P
E
D
K
A
T
2640
2641
P
M
L
K
M
R
T
S
F
H
G
C
I
K
N
V
V
L
D
A
Q
L
L
D
F
T
H
A
T
G
S
E
Q
V
E
L
D
T
C
L
L
A
E
E
P
M
Q
S
L
H
R
E
H
G
E
L
P
P
E
P
2700
2701
P
T
L
P
Q
P
E
L
C
A
V
D
T
A
P
G
Y
V
A
G
A
H
Q
F
G
L
S
Q
N
S
H
L
V
L
P
L
N
Q
S
D
V
R
K
R
L
Q
V
Q
L
S
I
R
T
F
A
S
S
G
L
I
2760
2761
Y
Y
V
A
H
Q
N
Q
M
D
Y
A
T
L
Q
L
Q
E
G
R
L
H
F
M
F
D
L
G
K
G
R
T
K
V
S
H
P
A
L
L
S
D
G
K
W
H
T
V
K
T
E
Y
I
K
R
K
A
F
M
T
2820
2821
V
D
G
Q
E
S
P
S
V
T
V
V
G
N
A
T
T
L
D
V
E
R
K
L
Y
L
G
G
L
P
S
H
Y
R
A
R
N
I
G
T
I
T
H
S
I
P
A
C
I
G
E
I
M
V
N
G
Q
Q
L
D
2880
2881
K
D
R
P
L
S
A
S
A
V
D
R
C
Y
V
V
A
Q
E
G
T
F
F
E
G
S
G
Y
A
A
L
V
K
E
G
Y
K
V
R
L
D
L
N
I
T
L
E
F
R
T
T
S
K
N
G
V
L
L
G
I
2940
2941
S
S
A
K
V
D
A
I
G
L
E
I
V
D
G
K
V
L
F
H
V
N
N
G
A
G
R
I
T
A
T
Y
Q
P
R
A
A
R
A
L
C
D
G
K
W
H
T
L
Q
A
H
K
S
K
H
R
I
V
L
T
3000
3001
V
D
G
N
S
V
R
A
E
S
P
H
T
H
S
T
S
A
D
T
N
D
P
I
Y
V
G
G
Y
P
A
H
I
K
Q
N
C
L
S
S
R
A
S
F
R
G
C
V
R
N
L
R
L
S
R
G
S
Q
V
Q
3060
3061
S
L
D
L
S
R
A
F
D
L
Q
G
V
F
P
H
S
C
P
G
P
E
P
3083
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1717
Peptide:
LSNIDYILIKAS
Length:
12
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P19137
UniProt Name:
LAMA1_MOUSE
Protein Name:
Laminin subunit alpha-1 (Laminin A chain)
Position:
1321-1332
Literature
PMID:
17348688
Reference:
Biochemistry. 2007 Apr 3;46(13):3966-74.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
58.33
NuAPRpred:
2.35
Tango:
21.81
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
33.1
Area of the profile Above Threshold (AGGRESCAN):
4.48
Best Energy Score (PASTA 2.0):
-5.69
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1718 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
I
L
K
L
Q
V
F
L
I
V
L
S
V
A
L
N
H
L
K
A
T
P
I
E
S
H
Q
V
E
K
R
K
C
N
T
A
T
C
A
T
Q
R
L
A
N
F
L
V
H
S
S
N
N
F
G
A
I
L
60
61
S
S
T
N
V
G
S
N
T
Y
G
K
R
N
A
V
E
V
L
K
R
E
P
L
N
Y
L
P
L
89
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1718
Peptide:
NFGAILSSTNVG
Length:
12
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P10997
UniProt Name:
IAPP_HUMAN
Protein Name:
Islet amyloid polypeptide (Amylin)
Position:
55-66
Literature
PMID:
17468747
Reference:
Nature. 2007 May 24;447(7143):453-7.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
41.67
NuAPRpred:
1.3
Tango:
30.11
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.6
Area of the profile Above Threshold (AGGRESCAN):
2.79
Best Energy Score (PASTA 2.0):
-3.46
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1719 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
P
P
Y
T
I
T
Y
F
P
V
R
G
R
C
E
A
M
R
M
L
L
A
D
Q
D
Q
S
W
K
E
E
V
V
T
M
E
T
W
P
P
L
K
P
S
C
L
F
R
Q
L
P
K
F
Q
D
G
D
L
T
L
60
61
Y
Q
S
N
A
I
L
R
H
L
G
R
S
F
G
L
Y
G
K
D
Q
K
E
A
A
L
V
D
M
V
N
D
G
V
E
D
L
R
C
K
Y
A
T
L
I
Y
T
N
Y
E
A
G
K
E
K
Y
V
K
E
L
120
121
P
E
H
L
K
P
F
E
T
L
L
S
Q
N
Q
G
G
Q
A
F
V
V
G
S
Q
I
S
F
A
D
Y
N
L
L
D
L
L
R
I
H
Q
V
L
N
P
S
C
L
D
A
F
P
L
L
S
A
Y
V
A
R
180
181
L
S
A
R
P
K
I
K
A
F
L
A
S
P
E
H
V
N
R
P
I
N
G
N
G
K
N
207
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1719
Peptide:
PLLSAYVARLSA
Length:
12
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P80031
UniProt Name:
GSTP1_PIG
Protein Name:
Glutathione S-transferase P
Position:
172-183
Literature
PMID:
11370666
Reference:
Arch Biochem Biophys. 2001 May 1;389(1):15-21.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
75.0
NuAPRpred:
-0.84
Tango:
81.91
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
26.4
Area of the profile Above Threshold (AGGRESCAN):
3.78
Best Energy Score (PASTA 2.0):
-2.79
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1720 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
R
G
S
G
T
G
A
A
L
L
V
L
L
A
S
V
L
W
V
T
V
R
S
Q
Q
R
G
L
F
P
A
I
L
N
L
A
T
N
A
H
I
S
A
N
A
T
C
G
E
K
G
P
E
M
F
C
K
L
V
60
61
E
H
V
P
G
R
P
V
R
H
A
Q
C
R
V
C
D
G
N
S
T
N
P
R
E
R
H
P
I
S
H
A
I
D
G
T
N
N
W
W
Q
S
P
S
I
Q
N
G
R
E
Y
H
W
V
T
V
T
L
D
L
120
121
R
Q
V
F
Q
V
A
Y
I
I
I
K
A
A
N
A
P
R
P
G
N
W
I
L
E
R
S
V
D
G
V
K
F
K
P
W
Q
Y
Y
A
V
S
D
T
E
C
L
T
R
Y
K
I
T
P
R
R
G
P
P
T
180
181
Y
R
A
D
N
E
V
I
C
T
S
Y
Y
S
K
L
V
P
L
E
H
G
E
I
H
T
S
L
I
N
G
R
P
S
A
D
D
P
S
P
Q
L
L
E
F
T
S
A
R
Y
I
R
L
R
L
Q
R
I
R
T
240
241
L
N
A
D
L
M
T
L
S
H
R
D
L
R
D
L
D
P
I
V
T
R
R
Y
Y
Y
S
I
K
D
I
S
V
G
G
M
C
I
C
Y
G
H
A
S
S
C
P
W
D
E
E
A
K
Q
L
Q
C
Q
C
E
300
301
H
N
T
C
G
E
S
C
D
R
C
C
P
G
Y
H
Q
Q
P
W
R
P
G
T
I
S
S
G
N
E
C
E
E
C
N
C
H
N
K
A
K
D
C
Y
Y
D
S
S
V
A
K
E
R
R
S
L
N
T
A
G
360
361
Q
Y
S
G
G
G
V
C
V
N
C
S
Q
N
T
T
G
I
N
C
E
T
C
I
D
Q
Y
Y
R
P
H
K
V
S
P
Y
D
D
H
P
C
R
P
C
N
C
D
P
V
G
S
L
S
S
V
C
I
K
D
D
420
421
R
H
A
D
L
A
N
G
K
W
P
G
Q
C
P
C
R
K
G
Y
A
G
D
K
C
D
R
C
Q
F
G
Y
R
G
F
P
N
C
I
P
C
D
C
R
T
V
G
S
L
N
E
D
P
C
I
E
P
C
L
C
480
481
K
K
N
V
E
G
K
N
C
D
R
C
K
P
G
F
Y
N
L
K
E
R
N
P
E
G
C
S
E
C
F
C
F
G
V
S
G
V
C
D
S
L
T
W
S
I
S
Q
V
T
N
M
S
G
W
L
V
T
D
L
540
541
M
S
T
N
K
I
R
S
Q
Q
D
V
L
G
G
H
R
Q
I
S
I
N
N
T
A
V
M
Q
R
L
T
S
T
Y
Y
W
A
A
P
E
A
Y
L
G
N
K
L
T
A
F
G
G
F
L
K
Y
T
V
S
Y
600
601
D
I
P
V
E
T
V
D
S
D
L
M
S
H
A
D
I
I
I
K
G
N
G
L
T
I
S
T
R
A
E
G
L
S
L
Q
P
Y
E
E
Y
F
N
V
V
R
L
V
P
E
N
F
R
D
F
D
T
R
R
E
660
661
I
D
R
D
Q
L
M
T
V
L
A
N
V
T
H
L
L
I
R
A
N
Y
N
S
A
K
M
A
L
Y
R
L
D
S
V
S
L
D
I
A
S
P
N
A
I
D
L
A
V
A
A
D
V
E
H
C
E
C
P
Q
720
721
G
Y
T
G
T
S
C
E
A
C
L
P
G
Y
Y
R
V
D
G
I
L
F
G
G
I
C
Q
P
C
E
C
H
G
H
A
S
E
C
D
I
H
G
I
C
S
V
C
T
H
N
T
T
G
D
H
C
E
Q
C
L
780
781
P
G
F
Y
G
T
P
S
R
G
T
P
G
D
C
Q
P
C
A
C
P
L
S
I
D
S
N
N
F
S
P
T
C
H
L
T
D
G
E
E
V
V
C
D
Q
C
A
P
G
Y
S
G
S
W
C
E
R
C
A
D
840
841
G
Y
Y
G
N
P
T
V
P
G
G
T
C
V
P
C
N
C
S
G
N
V
D
P
L
E
A
G
H
C
D
S
V
T
G
E
C
L
K
C
L
W
N
T
D
G
A
H
C
E
R
C
A
D
G
F
Y
G
D
A
900
901
V
T
A
K
N
C
R
A
C
D
C
H
E
N
G
S
L
S
G
I
C
H
L
E
T
G
L
C
D
C
K
P
H
V
T
G
Q
Q
C
D
Q
C
L
S
G
Y
Y
G
L
D
T
G
L
G
C
V
P
C
N
C
960
961
S
V
E
G
S
V
S
D
N
C
T
E
E
G
Q
C
H
C
G
P
G
V
S
G
K
Q
C
D
R
C
S
H
G
F
Y
A
F
Q
D
G
G
C
T
P
C
D
C
A
H
T
Q
N
N
C
D
P
A
S
G
E
1020
1021
C
L
C
P
P
H
T
Q
G
L
K
C
E
E
C
E
E
A
Y
W
G
L
D
P
E
Q
G
C
Q
A
C
N
C
S
A
V
G
S
T
S
A
Q
C
D
V
L
S
G
H
C
P
C
K
K
G
F
G
G
Q
S
1080
1081
C
H
Q
C
S
L
G
Y
R
S
F
P
D
C
V
P
C
G
C
D
L
R
G
T
L
P
D
T
C
D
L
E
Q
G
L
C
S
C
S
E
D
G
G
T
C
S
C
K
E
N
A
V
G
P
Q
C
S
K
C
Q
1140
1141
A
G
T
F
A
L
R
G
D
N
P
Q
G
C
S
P
C
F
C
F
G
L
S
Q
L
C
S
E
L
E
G
Y
V
R
T
L
I
T
L
A
S
D
Q
P
L
L
H
V
V
S
Q
S
N
L
K
G
T
I
E
G
1200
1201
V
H
F
Q
P
P
D
T
L
L
D
A
E
A
V
R
Q
H
I
Y
A
E
P
F
Y
W
R
L
P
K
Q
F
Q
G
D
Q
L
L
A
Y
G
G
K
L
Q
Y
S
V
A
F
Y
S
T
L
G
T
G
T
S
N
1260
1261
Y
E
P
Q
V
L
I
K
G
G
R
A
R
K
H
V
I
Y
M
D
A
P
A
P
E
N
G
V
R
Q
D
Y
E
V
R
M
K
E
E
F
W
K
Y
F
N
S
V
S
E
K
H
V
T
H
S
D
F
M
S
V
1320
1321
L
S
N
I
D
Y
I
L
I
K
A
S
Y
G
Q
G
L
Q
Q
S
R
I
A
N
I
S
M
E
V
G
R
K
A
V
E
L
P
A
E
G
E
A
A
L
L
L
E
L
C
V
C
P
P
G
T
A
G
H
S
C
1380
1381
Q
D
C
A
P
G
Y
Y
R
E
K
L
P
E
S
G
G
R
G
P
R
P
L
L
A
P
C
V
P
C
N
C
N
N
H
S
D
V
C
D
P
E
T
G
K
C
L
S
C
R
D
H
T
S
G
D
H
C
E
L
1440
1441
C
A
S
G
Y
Y
G
K
V
T
G
L
P
G
D
C
T
P
C
T
C
P
H
H
P
P
F
S
F
S
P
T
C
V
V
E
G
D
S
D
F
R
C
N
A
C
L
P
G
Y
E
G
Q
Y
C
E
R
C
S
A
1500
1501
G
Y
H
G
N
P
R
A
A
G
G
S
C
Q
T
C
D
C
N
P
Q
G
S
V
H
S
D
C
D
R
A
S
G
Q
C
V
C
K
P
G
A
T
G
L
H
C
E
K
C
L
P
R
H
I
L
M
E
S
D
C
1560
1561
V
S
C
D
D
D
C
V
G
P
L
L
N
D
L
D
S
V
G
D
A
V
L
S
L
N
L
T
G
V
S
P
A
P
Y
G
I
L
E
N
L
E
N
T
T
K
Y
F
Q
R
Y
L
I
K
E
N
A
K
K
I
1620
1621
R
A
E
I
Q
L
E
G
I
A
E
Q
T
E
N
L
Q
K
E
L
T
R
V
L
A
R
H
Q
K
V
N
A
E
M
E
R
T
S
N
G
T
Q
A
L
A
T
F
I
E
Q
L
H
A
N
I
K
E
I
T
E
1680
1681
K
V
A
T
L
N
Q
T
A
R
K
D
F
Q
P
P
V
S
A
L
Q
S
M
H
Q
N
I
S
S
L
L
G
L
I
K
E
R
N
F
T
E
M
Q
Q
N
A
T
L
E
L
K
A
A
K
D
L
L
S
R
I
1740
1741
Q
K
R
F
Q
K
P
Q
E
K
L
K
A
L
K
E
A
N
S
L
L
S
N
H
S
E
K
L
Q
A
A
E
E
L
L
K
E
A
G
S
K
T
Q
E
S
N
L
L
L
L
L
V
K
A
N
L
K
E
F
Q
1800
1801
E
K
K
L
R
V
Q
E
E
Q
N
V
T
S
E
L
I
A
K
G
R
E
W
V
D
A
A
G
T
H
T
A
A
A
Q
D
T
L
T
Q
L
E
H
H
R
D
E
L
L
L
W
A
R
K
I
R
S
H
V
D
1860
1861
D
L
V
M
Q
M
S
K
R
R
A
R
D
L
V
H
R
A
E
Q
H
A
S
E
L
Q
S
R
A
G
A
L
D
R
D
L
E
N
V
R
N
V
S
L
N
A
T
S
A
A
H
V
H
S
N
I
Q
T
L
T
1920
1921
E
E
A
E
M
L
A
A
D
A
H
K
T
A
N
K
T
D
L
I
S
E
S
L
A
S
R
G
K
A
V
L
Q
R
S
S
R
F
L
K
E
S
V
S
T
R
R
K
Q
Q
G
I
T
M
K
L
D
E
L
K
1980
1981
N
L
T
S
Q
F
Q
E
S
M
D
N
I
M
K
Q
A
N
D
S
L
A
M
L
R
E
S
P
G
G
M
R
E
K
G
R
K
A
R
E
L
A
A
A
A
N
E
S
A
V
K
T
L
E
D
V
L
A
L
S
2040
2041
L
R
V
F
N
T
S
E
D
L
S
R
V
N
A
T
V
Q
E
T
N
D
L
L
H
N
S
T
M
T
T
L
L
A
G
R
K
M
K
D
M
E
M
Q
A
N
L
L
L
D
R
L
K
P
L
K
T
L
E
E
2100
2101
N
L
S
R
N
L
S
E
I
K
L
L
I
S
R
A
R
K
Q
V
A
S
I
K
V
A
V
S
A
D
R
D
C
I
R
A
Y
Q
P
Q
T
S
S
T
N
Y
N
T
L
I
L
N
V
K
T
Q
E
P
D
N
2160
2161
L
L
F
Y
L
G
S
S
S
S
S
D
F
L
A
V
E
M
R
R
G
K
V
A
F
L
W
D
L
G
S
G
S
T
R
L
E
F
P
E
V
S
I
N
N
N
R
W
H
S
I
Y
I
T
R
F
G
N
M
G
2220
2221
S
L
S
V
K
E
A
S
A
A
E
N
P
P
V
R
T
S
K
S
P
G
P
S
K
V
L
D
I
N
N
S
T
L
M
F
V
G
G
L
G
G
Q
I
K
K
S
P
A
V
K
V
T
H
F
K
G
C
M
G
2280
2281
E
A
F
L
N
G
K
S
I
G
L
W
N
Y
I
E
R
E
G
K
C
N
G
C
F
G
S
S
Q
N
E
D
S
S
F
H
F
D
G
S
G
Y
A
M
V
E
K
T
L
R
P
T
V
T
Q
I
V
I
L
F
2340
2341
S
T
F
S
P
N
G
L
L
F
Y
L
A
S
N
G
T
K
D
F
L
S
I
E
L
V
R
G
R
V
K
V
M
V
D
L
G
S
G
P
L
T
L
M
T
D
R
R
Y
N
N
G
T
W
Y
K
I
A
F
Q
2400
2401
R
N
R
K
Q
G
L
L
A
V
F
D
A
Y
D
T
S
D
K
E
T
K
Q
G
E
T
P
G
A
A
S
D
L
N
R
L
E
K
D
L
I
Y
V
G
G
L
P
H
S
K
A
V
R
K
G
V
S
S
R
S
2460
2461
Y
V
G
C
I
K
N
L
E
I
S
R
S
T
F
D
L
L
R
N
S
Y
G
V
R
K
G
C
A
L
E
P
I
Q
S
V
S
F
L
R
G
G
Y
V
E
M
P
P
K
S
L
S
P
E
S
S
L
L
A
T
2520
2521
F
A
T
K
N
S
S
G
I
L
L
V
A
L
G
K
D
A
E
E
A
G
G
A
Q
A
H
V
P
F
F
S
I
M
L
L
E
G
R
I
E
V
H
V
N
S
G
D
G
T
S
L
R
K
A
L
L
H
A
P
2580
2581
T
G
S
Y
S
D
G
Q
E
H
S
I
S
L
V
R
N
R
R
V
I
T
I
Q
V
D
E
N
S
P
V
E
M
K
L
G
P
L
T
E
G
K
T
I
D
I
S
N
L
Y
I
G
G
L
P
E
D
K
A
T
2640
2641
P
M
L
K
M
R
T
S
F
H
G
C
I
K
N
V
V
L
D
A
Q
L
L
D
F
T
H
A
T
G
S
E
Q
V
E
L
D
T
C
L
L
A
E
E
P
M
Q
S
L
H
R
E
H
G
E
L
P
P
E
P
2700
2701
P
T
L
P
Q
P
E
L
C
A
V
D
T
A
P
G
Y
V
A
G
A
H
Q
F
G
L
S
Q
N
S
H
L
V
L
P
L
N
Q
S
D
V
R
K
R
L
Q
V
Q
L
S
I
R
T
F
A
S
S
G
L
I
2760
2761
Y
Y
V
A
H
Q
N
Q
M
D
Y
A
T
L
Q
L
Q
E
G
R
L
H
F
M
F
D
L
G
K
G
R
T
K
V
S
H
P
A
L
L
S
D
G
K
W
H
T
V
K
T
E
Y
I
K
R
K
A
F
M
T
2820
2821
V
D
G
Q
E
S
P
S
V
T
V
V
G
N
A
T
T
L
D
V
E
R
K
L
Y
L
G
G
L
P
S
H
Y
R
A
R
N
I
G
T
I
T
H
S
I
P
A
C
I
G
E
I
M
V
N
G
Q
Q
L
D
2880
2881
K
D
R
P
L
S
A
S
A
V
D
R
C
Y
V
V
A
Q
E
G
T
F
F
E
G
S
G
Y
A
A
L
V
K
E
G
Y
K
V
R
L
D
L
N
I
T
L
E
F
R
T
T
S
K
N
G
V
L
L
G
I
2940
2941
S
S
A
K
V
D
A
I
G
L
E
I
V
D
G
K
V
L
F
H
V
N
N
G
A
G
R
I
T
A
T
Y
Q
P
R
A
A
R
A
L
C
D
G
K
W
H
T
L
Q
A
H
K
S
K
H
R
I
V
L
T
3000
3001
V
D
G
N
S
V
R
A
E
S
P
H
T
H
S
T
S
A
D
T
N
D
P
I
Y
V
G
G
Y
P
A
H
I
K
Q
N
C
L
S
S
R
A
S
F
R
G
C
V
R
N
L
R
L
S
R
G
S
Q
V
Q
3060
3061
S
L
D
L
S
R
A
F
D
L
Q
G
V
F
P
H
S
C
P
G
P
E
P
3083
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1720
Peptide:
SAKVDAIGLEIV
Length:
12
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P19137
UniProt Name:
LAMA1_MOUSE
Protein Name:
Laminin subunit alpha-1 (Laminin A chain)
Position:
2942-2953
Literature
PMID:
17348688
Reference:
Biochemistry. 2007 Apr 3;46(13):3966-74.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
58.33
NuAPRpred:
0.95
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
14.7
Area of the profile Above Threshold (AGGRESCAN):
2.99
Best Energy Score (PASTA 2.0):
-2.77
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1721 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
K
C
L
L
L
A
L
G
L
A
L
A
C
A
A
Q
A
I
I
V
T
Q
T
M
K
G
L
D
I
Q
K
V
A
G
T
W
Y
S
L
A
M
A
A
S
D
I
S
L
L
D
A
Q
S
A
P
L
R
V
Y
60
61
V
E
E
L
K
P
T
P
E
G
D
L
E
I
L
L
Q
K
W
E
N
G
E
C
A
Q
K
K
I
I
A
E
K
T
K
I
P
A
V
F
K
I
D
A
L
N
E
N
K
V
L
V
L
D
T
D
Y
K
K
Y
120
121
L
L
F
C
M
E
N
S
A
E
P
E
Q
S
L
A
C
Q
C
L
V
R
T
P
E
V
D
D
E
A
L
E
K
F
D
K
A
L
K
A
L
P
M
H
I
R
L
S
F
N
P
T
Q
L
E
E
Q
C
H
V
180
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1721
Peptide:
SLVCQCLVRTPW
Length:
12
Classification:
Amyloid
Mutation(s):
A136V, E145W
Structure(s):
No structures
Protein Information
UniProt ID:
P02755
UniProt Name:
LACB_BUBBU
Protein Name:
Beta-lactoglobulin (Beta-LG)
Position:
134-145
Literature
PMID:
19133274
Reference:
J Mol Biol. 2009 Feb 27;386(3):878-90.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
66.67
NuAPRpred:
2.68
Tango:
3.13
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
26.8
Area of the profile Above Threshold (AGGRESCAN):
4.31
Best Energy Score (PASTA 2.0):
-5.66
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1722 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
G
L
L
Q
V
F
A
F
G
V
L
A
L
W
G
T
R
V
C
A
Q
E
P
E
F
S
Y
G
C
A
E
G
S
C
Y
P
A
T
G
D
L
L
I
G
R
A
Q
K
L
S
V
T
S
T
C
G
L
H
K
60
61
P
E
P
Y
C
I
V
S
H
L
Q
E
D
K
K
C
F
I
C
D
S
R
D
P
Y
H
E
T
L
N
P
D
S
H
L
I
E
N
V
V
T
T
F
A
P
N
R
L
K
I
W
W
Q
S
E
N
G
V
E
N
120
121
V
T
I
Q
L
D
L
E
A
E
F
H
F
T
H
L
I
M
T
F
K
T
F
R
P
A
A
M
L
I
E
R
S
S
D
F
G
K
A
W
G
V
Y
R
Y
F
A
Y
D
C
E
S
S
F
P
G
I
S
T
G
180
181
P
M
K
K
V
D
D
I
I
C
D
S
R
Y
S
D
I
E
P
S
T
E
G
E
V
I
F
R
A
L
D
P
A
F
K
I
E
D
P
Y
S
P
R
I
Q
N
L
L
K
I
T
N
L
R
I
K
F
V
K
L
240
241
H
T
L
G
D
N
L
L
D
S
R
M
E
I
R
E
K
Y
Y
Y
A
V
Y
D
M
V
V
R
G
N
C
F
C
Y
G
H
A
S
E
C
A
P
V
D
G
V
N
E
E
V
E
G
M
V
H
G
H
C
M
C
300
301
R
H
N
T
K
G
L
N
C
E
L
C
M
D
F
Y
H
D
L
P
W
R
P
A
E
G
R
N
S
N
A
C
K
K
C
N
C
N
E
H
S
S
S
C
H
F
D
M
A
V
F
L
A
T
G
N
V
S
G
G
360
361
V
C
D
N
C
Q
H
N
T
M
G
R
N
C
E
Q
C
K
P
F
Y
F
Q
H
P
E
R
D
I
R
D
P
N
L
C
E
P
C
T
C
D
P
A
G
S
E
N
G
G
I
C
D
G
Y
T
D
F
S
V
G
420
421
L
I
A
G
Q
C
R
C
K
L
H
V
E
G
E
R
C
D
V
C
K
E
G
F
Y
D
L
S
A
E
D
P
Y
G
C
K
S
C
A
C
N
P
L
G
T
I
P
G
G
N
P
C
D
S
E
T
G
Y
C
Y
480
481
C
K
R
L
V
T
G
Q
R
C
D
Q
C
L
P
Q
H
W
G
L
S
N
D
L
D
G
C
R
P
C
D
C
D
L
G
G
A
L
N
N
S
C
S
E
D
S
G
Q
C
S
C
L
P
H
M
I
G
R
Q
C
540
541
N
E
V
E
S
G
Y
Y
F
T
T
L
D
H
Y
I
Y
E
A
E
E
A
N
L
G
P
G
V
I
V
V
E
R
Q
Y
I
Q
D
R
I
P
S
W
T
G
P
G
F
V
R
V
P
E
G
A
Y
L
E
F
F
600
601
I
D
N
I
P
Y
S
M
E
Y
E
I
L
I
R
Y
E
P
Q
L
P
D
H
W
E
K
A
V
I
T
V
Q
R
P
G
K
I
P
A
S
S
R
C
G
N
T
V
P
D
D
D
N
Q
V
V
S
L
S
P
G
660
661
S
R
Y
V
V
L
P
R
P
V
C
F
E
K
G
M
N
Y
T
V
R
L
E
L
P
Q
Y
T
A
S
G
S
D
V
E
S
P
Y
T
F
I
D
S
L
V
L
M
P
Y
C
K
S
L
D
I
F
T
V
G
G
720
721
S
G
D
G
E
V
T
N
S
A
W
E
T
F
Q
R
Y
R
C
L
E
N
S
R
S
V
V
K
T
P
M
T
D
V
C
R
N
I
I
F
S
I
S
A
L
I
H
Q
T
G
L
A
C
E
C
D
P
Q
G
S
780
781
L
S
S
V
C
D
P
N
G
G
Q
C
Q
C
R
P
N
V
V
G
R
T
C
N
R
C
A
P
G
T
F
G
F
G
P
N
G
C
K
P
C
D
C
H
L
Q
G
S
A
S
A
F
C
D
A
I
T
G
Q
C
840
841
H
C
F
Q
G
I
Y
A
R
Q
C
D
R
C
L
P
G
Y
W
G
F
P
S
C
Q
P
C
Q
C
N
G
H
A
L
D
C
D
T
V
T
G
E
C
L
S
C
Q
D
Y
T
T
G
H
N
C
E
R
C
L
A
900
901
G
Y
Y
G
D
P
I
I
G
S
G
D
H
C
R
P
C
P
C
P
D
G
P
D
S
G
R
Q
F
A
R
S
C
Y
Q
D
P
V
T
L
Q
L
A
C
V
C
D
P
G
Y
I
G
S
R
C
D
D
C
A
S
960
961
G
F
F
G
N
P
S
D
F
G
G
S
C
Q
P
C
Q
C
H
H
N
I
D
T
T
D
P
E
A
C
D
K
E
T
G
R
C
L
K
C
L
Y
H
T
E
G
D
H
C
Q
L
C
Q
Y
G
Y
Y
G
D
A
1020
1021
L
R
Q
D
C
R
K
C
V
C
N
Y
L
G
T
V
K
E
H
C
N
G
S
D
C
H
C
D
K
A
T
G
Q
C
S
C
L
P
N
V
I
G
Q
N
C
D
R
C
A
P
N
T
W
Q
L
A
S
G
T
G
1080
1081
C
G
P
C
N
C
N
A
A
H
S
F
G
P
S
C
N
E
F
T
G
Q
C
Q
C
M
P
G
F
G
G
R
T
C
S
E
C
Q
E
L
F
W
G
D
P
D
V
E
C
R
A
C
D
C
D
P
R
G
I
E
1140
1141
T
P
Q
C
D
Q
S
T
G
Q
C
V
C
V
E
G
V
E
G
P
R
C
D
K
C
T
R
G
Y
S
G
V
F
P
D
C
T
P
C
H
Q
C
F
A
L
W
D
A
I
I
G
E
L
T
N
R
T
H
K
F
1200
1201
L
E
K
A
K
A
L
K
I
S
G
V
I
G
P
Y
R
E
T
V
D
S
V
E
K
K
V
N
E
I
K
D
I
L
A
Q
S
P
A
A
E
P
L
K
N
I
G
I
L
F
E
E
A
E
K
L
T
K
D
V
1260
1261
T
E
K
M
A
Q
V
E
V
K
L
T
D
T
A
S
Q
S
N
S
T
A
G
E
L
G
A
L
Q
A
E
A
E
S
L
D
K
T
V
K
E
L
A
E
Q
L
E
F
I
K
N
S
D
I
Q
G
A
L
D
S
1320
1321
I
T
K
Y
F
Q
M
S
L
E
A
E
K
R
V
N
A
S
T
T
D
P
N
S
T
V
E
Q
S
A
L
T
R
D
R
V
E
D
L
M
L
E
R
E
S
P
F
K
E
Q
Q
E
E
Q
A
R
L
L
D
E
1380
1381
L
A
G
K
L
Q
S
L
D
L
S
A
V
A
Q
M
T
C
G
T
P
P
G
A
D
C
S
E
S
E
C
G
G
P
N
C
R
T
D
E
G
E
K
K
C
G
G
P
G
C
G
G
L
V
T
V
A
H
S
A
1440
1441
W
Q
K
A
M
D
F
D
R
D
V
L
S
A
L
A
E
V
E
Q
L
S
K
M
V
S
E
A
K
V
R
A
D
E
A
K
Q
N
A
Q
D
V
L
L
K
T
N
A
T
K
E
K
V
D
K
S
N
E
D
L
1500
1501
R
N
L
I
K
Q
I
R
N
F
L
T
E
D
S
A
D
L
D
S
I
E
A
V
A
N
E
V
L
K
M
E
M
P
S
T
P
Q
Q
L
Q
N
L
T
E
D
I
R
E
R
V
E
T
L
S
Q
V
E
V
I
1560
1561
L
Q
Q
S
A
A
D
I
A
R
A
E
L
L
L
E
E
A
K
R
A
S
K
S
A
T
D
V
K
V
T
A
D
M
V
K
E
A
L
E
E
A
E
K
A
Q
V
A
A
E
K
A
I
K
Q
A
D
E
D
I
1620
1621
Q
G
T
Q
N
L
L
T
S
I
E
S
E
T
A
A
S
E
E
T
L
T
N
A
S
Q
R
I
S
K
L
E
R
N
V
E
E
L
K
R
K
A
A
Q
N
S
G
E
A
E
Y
I
E
K
V
V
Y
S
V
K
1680
1681
Q
N
A
D
D
V
K
K
T
L
D
G
E
L
D
E
K
Y
K
K
V
E
S
L
I
A
Q
K
T
E
E
S
A
D
A
R
R
K
A
E
L
L
Q
N
E
A
K
T
L
L
A
Q
A
N
S
K
L
Q
L
L
1740
1741
E
D
L
E
R
K
Y
E
D
N
Q
K
Y
L
E
D
K
A
Q
E
L
V
R
L
E
G
E
V
R
S
L
L
K
D
I
S
E
K
V
A
V
Y
S
T
C
L
1786
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1722
Peptide:
VILQQSAADIAR
Length:
12
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02469
UniProt Name:
LAMB1_MOUSE
Protein Name:
Laminin subunit beta-1 (Laminin B1 chain)
Position:
1559-1570
Literature
PMID:
17348688
Reference:
Biochemistry. 2007 Apr 3;46(13):3966-74.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
58.33
NuAPRpred:
-1.1
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-12.6
Area of the profile Above Threshold (AGGRESCAN):
1.62
Best Energy Score (PASTA 2.0):
-3.3
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1723 Classification: Amyloid
CSV
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Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1723
Peptide:
VTGVTAVAQKTV
Length:
12
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
71-82
Literature
PMID:
11060312
Reference:
J Biol Chem. 2001 Jan 26;276(4):2380-6.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
50.0
NuAPRpred:
-0.85
Tango:
12.74
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
7.6
Area of the profile Above Threshold (AGGRESCAN):
2.3
Best Energy Score (PASTA 2.0):
-4.34
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1724 Classification: Amyloid
CSV
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Peptide details
Entry:
P-1724
Peptide:
VTVKVDAVKVTV
Length:
12
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
10366514
Reference:
J Mol Biol. 1999 Jun 4;289(2):413-28.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
58.33
NuAPRpred:
0.81
Tango:
3.69
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
23.7
Area of the profile Above Threshold (AGGRESCAN):
3.14
Best Energy Score (PASTA 2.0):
-7.52
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1725 Classification: Amyloid
CSV
JSON
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Peptide details
Entry:
P-1725
Peptide:
VTVKVEAVKVTV
Length:
12
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
10366514
Reference:
J Mol Biol. 1999 Jun 4;289(2):413-28.
source:
CPAD
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
58.33
NuAPRpred:
1.25
Tango:
5.78
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
27.2
Area of the profile Above Threshold (AGGRESCAN):
3.57
Best Energy Score (PASTA 2.0):
-6.39
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1726 Classification: Amyloid
CSV
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Peptide details
Entry:
P-1726
Peptide:
VTVKVNAVKVTV
Length:
12
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
10366514
Reference:
J Mol Biol. 1999 Jun 4;289(2):413-28.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
2
Absolute Charge:
2
Hydrophobicity:
58.33
NuAPRpred:
1.84
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
28.2
Area of the profile Above Threshold (AGGRESCAN):
3.68
Best Energy Score (PASTA 2.0):
-8.99
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1727 Classification: Amyloid
CSV
JSON
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Peptide details
Entry:
P-1727
Peptide:
WQQVLNVWGKVE
Length:
12
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
MYG_HUMAN
Protein Name:
Position:
Literature
PMID:
17766358
Reference:
Biophys J. 2007 Dec 15;93(12):4382-91.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
2
Hydrophobicity:
50.0
NuAPRpred:
4.19
Tango:
20.87
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
6.7
Area of the profile Above Threshold (AGGRESCAN):
2.66
Best Energy Score (PASTA 2.0):
-5.64
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1728 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
K
M
S
R
L
C
L
S
V
A
L
L
V
L
L
G
T
L
A
A
S
T
P
G
C
D
T
S
N
Q
A
K
A
Q
R
P
D
F
C
L
E
P
P
Y
T
G
P
C
K
A
R
I
I
R
Y
F
Y
N
A
60
61
K
A
G
L
C
Q
T
F
V
Y
G
G
C
R
A
K
R
N
N
F
K
S
A
E
D
C
M
R
T
C
G
G
A
I
G
P
W
E
N
L
100
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1728
Peptide:
ARIIRYFYNAKAG
Length:
13
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P00974
UniProt Name:
BPT1_BOVIN
Protein Name:
Pancreatic trypsin inhibitor (Aprotinin)
Position:
51-63
Literature
PMID:
7504737
Reference:
J Mol Biol. 1993 Dec 5;234(3):861-78.
source:
AmyLoad
Derived Information
Net Charge:
3
Absolute Charge:
3
Hydrophobicity:
61.54
NuAPRpred:
-1.76
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
16.3
Area of the profile Above Threshold (AGGRESCAN):
4.23
Best Energy Score (PASTA 2.0):
-4.45
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1729 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1729
Peptide:
ATQRLANFLVHSS
Length:
13
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
12648568
Reference:
J Struct Biol. 2003 Mar;141(3):218-27.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
46.15
NuAPRpred:
0.2
Tango:
35.03
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-2.4
Area of the profile Above Threshold (AGGRESCAN):
2.97
Best Energy Score (PASTA 2.0):
-3.88
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1730 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1730
Peptide:
DWSFYLLYYTEFT
Length:
13
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
79-91
Literature
PMID:
16537488
Reference:
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4079-82.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
61.54
NuAPRpred:
4.83
Tango:
762.98
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
49.2
Area of the profile Above Threshold (AGGRESCAN):
7.39
Best Energy Score (PASTA 2.0):
-4.32
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1731 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
G
Q
A
F
R
K
F
L
P
L
F
D
R
V
L
V
E
R
S
A
A
E
T
V
T
K
G
G
I
M
L
P
E
K
S
Q
G
K
V
L
Q
A
T
V
V
A
V
G
S
G
G
K
G
K
G
G
E
I
60
61
Q
P
V
S
V
K
V
G
D
K
V
L
L
P
E
Y
G
G
T
K
V
V
L
D
D
K
D
Y
F
L
F
R
D
G
D
I
L
G
K
Y
V
D
102
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1731
Peptide:
DYFLFRDGDILGK
Length:
13
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P26772
UniProt Name:
CH10_RAT
Protein Name:
heat shock protein, mitochondrial (Hsp10)
Position:
87-99
Literature
PMID:
18329043
Reference:
J Mol Biol. 2008 Apr 11;377(5):1593-606.
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
5
Hydrophobicity:
46.15
NuAPRpred:
-3.72
Tango:
2.18
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
8.0
Area of the profile Above Threshold (AGGRESCAN):
3.07
Best Energy Score (PASTA 2.0):
-3.25
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1732 Classification: Amyloid
CSV
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Close ×
Peptide details
Entry:
P-1732
Peptide:
EDVAVYYCHQYYS
Length:
13
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Literature
PMID:
16125973
Reference:
J Struct Biol. 2005 Sep;151(3):229-38.
source:
CPAD
Derived Information
Net Charge:
-2
Absolute Charge:
2
Hydrophobicity:
61.54
NuAPRpred:
4.81
Tango:
255.9
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
15.9
Area of the profile Above Threshold (AGGRESCAN):
3.72
Best Energy Score (PASTA 2.0):
-4.45
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1733 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
D
V
F
M
K
G
L
S
K
A
K
E
G
V
V
A
A
A
E
K
T
K
Q
G
V
A
E
A
A
G
K
T
K
E
G
V
L
Y
V
G
S
K
T
K
E
G
V
V
H
G
V
A
T
V
A
E
K
T
K
60
61
E
Q
V
T
N
V
G
G
A
V
V
T
G
V
T
A
V
A
Q
K
T
V
E
G
A
G
S
I
A
A
A
T
G
F
V
K
K
D
Q
L
G
K
N
E
E
G
A
P
Q
E
G
I
L
E
D
M
P
V
D
P
120
121
D
N
E
A
Y
E
M
P
S
E
E
G
Y
Q
D
Y
E
P
E
A
140
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1733
Peptide:
EQVTNVGGAVVTG
Length:
13
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P37840
UniProt Name:
SYUA_HUMAN
Protein Name:
Alpha-synuclein
Position:
61-73
Literature
PMID:
10759841
Reference:
Eur J Biochem. 2000 Apr;267(8):2186-94.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
-1
Absolute Charge:
1
Hydrophobicity:
38.46
NuAPRpred:
0.67
Tango:
11.02
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
5.6
Area of the profile Above Threshold (AGGRESCAN):
2.88
Best Energy Score (PASTA 2.0):
-4.99
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1734 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
S
T
A
Q
S
L
K
S
V
D
Y
E
V
F
G
R
V
Q
G
V
C
F
R
M
Y
T
E
D
E
A
R
K
I
G
V
V
G
W
V
K
N
T
S
K
G
T
V
T
G
Q
V
Q
G
P
E
D
K
V
N
60
61
S
M
K
S
W
L
S
K
V
G
S
P
S
S
R
I
D
R
T
N
F
S
N
E
K
T
I
S
K
L
E
Y
S
N
F
S
I
R
Y
99
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1734
Peptide:
ISKLEYSNFSVRY
Length:
13
Classification:
Amyloid
Mutation(s):
I97V
Structure(s):
No structures
Protein Information
UniProt ID:
P14621
UniProt Name:
ACYP2_HUMAN
Protein Name:
Acylphosphatase-2
Position:
87-99
Literature
PMID:
11799398
Reference:
Nat Struct Biol. 2002 Feb;9(2):137-43.
source:
CPAD, AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
3
Hydrophobicity:
46.15
NuAPRpred:
-1.02
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
10.4
Area of the profile Above Threshold (AGGRESCAN):
1.73
Best Energy Score (PASTA 2.0):
-2.35
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1735 Classification: Amyloid
CSV
JSON
Close ×
Peptide details
Entry:
P-1735
Peptide:
KLKLKLELELELG
Length:
13
Classification:
Amyloid
Mutation(s):
Structure(s):
No structures
Protein Information
UniProt ID:
UniProt Name:
Protein Name:
Position:
Synthetic
Literature
PMID:
9207218
Reference:
Biochem Biophys Res Commun. 1997 Jun 27;235(3):675-9.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
6
Hydrophobicity:
46.15
NuAPRpred:
2.94
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
1.7
Area of the profile Above Threshold (AGGRESCAN):
1.44
Best Energy Score (PASTA 2.0):
-3.01
Aggregate Orientation (PASTA 2.0):
Antiparallel
Entry: P-1736 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
D
E
P
P
Q
S
P
W
D
R
V
K
D
L
A
T
V
Y
V
D
V
L
K
D
S
G
R
D
Y
V
S
Q
F
E
G
S
A
L
G
K
Q
L
N
L
K
L
L
D
N
W
D
S
V
T
S
T
F
S
K
L
60
61
R
E
Q
L
G
P
V
T
Q
E
F
W
D
N
L
E
K
E
T
E
G
L
R
Q
E
M
S
K
D
L
E
E
V
K
A
K
V
Q
P
Y
L
D
D
F
Q
K
K
W
Q
E
E
M
E
L
Y
R
Q
K
V
E
120
121
P
L
R
A
E
L
Q
E
G
A
R
Q
K
L
H
E
L
Q
E
K
L
S
P
L
G
E
E
M
R
D
R
A
R
A
H
V
D
A
L
R
T
H
L
A
P
Y
S
D
E
L
R
Q
R
L
A
A
R
L
E
A
180
181
L
K
E
N
G
G
A
R
L
A
E
Y
H
A
K
A
T
E
H
L
S
T
L
S
E
K
A
K
P
A
L
E
D
L
R
Q
G
L
L
P
V
L
E
S
F
K
V
S
F
L
S
A
L
E
E
Y
T
K
K
L
240
241
N
T
Q
243
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1736
Peptide:
LDNWDSVTSTFSK
Length:
13
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P02647
UniProt Name:
APOA1_HUMAN
Protein Name:
Apolipoprotein A-I
Position:
46-59
Literature
PMID:
27992182
Reference:
Biochemistry. 2016 Dec 19
source:
CPAD
Derived Information
Net Charge:
-1
Absolute Charge:
3
Hydrophobicity:
30.77
NuAPRpred:
-2.62
Tango:
3.36
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-15.4
Area of the profile Above Threshold (AGGRESCAN):
1.04
Best Energy Score (PASTA 2.0):
-3.25
Aggregate Orientation (PASTA 2.0):
-
Entry: P-1737 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
A
L
F
V
R
L
L
A
L
A
L
A
L
A
L
G
P
A
A
T
L
A
G
P
A
K
S
P
Y
Q
L
V
L
Q
H
S
R
L
R
G
R
Q
H
G
P
N
V
C
A
V
Q
K
V
I
G
T
N
R
K
60
61
Y
F
T
N
C
K
Q
W
Y
Q
R
K
I
C
G
K
S
T
V
I
S
Y
E
C
C
P
G
Y
E
K
V
P
G
E
K
G
C
P
A
A
L
P
L
S
N
L
Y
E
T
L
G
V
V
G
S
T
T
T
Q
L
120
121
Y
T
D
R
T
E
K
L
R
P
E
M
E
G
P
G
S
F
T
I
F
A
P
S
N
E
A
W
A
S
L
P
A
E
V
L
D
S
L
V
S
N
V
N
I
E
L
L
N
A
L
R
Y
H
M
V
G
R
R
V
180
181
L
T
D
E
L
K
H
G
M
T
L
T
S
M
Y
Q
N
S
N
I
Q
I
H
H
Y
P
N
G
I
V
T
V
N
C
A
R
L
L
K
A
D
H
H
A
T
N
G
V
V
H
L
I
D
K
V
I
S
T
I
T
240
241
N
N
I
Q
Q
I
I
E
I
E
D
T
F
E
T
L
R
A
A
V
A
A
S
G
L
N
T
M
L
E
G
N
G
Q
Y
T
L
L
A
P
T
N
E
A
F
E
K
I
P
S
E
T
L
N
R
I
L
G
D
P
300
301
E
A
L
R
D
L
L
N
N
H
I
L
K
S
A
M
C
A
E
A
I
V
A
G
L
S
V
E
T
L
E
G
T
T
L
E
V
G
C
S
G
D
M
L
T
I
N
G
K
A
I
I
S
N
K
D
I
L
A
T
360
361
N
G
V
I
H
Y
I
D
E
L
L
I
P
D
S
A
K
T
L
F
E
L
A
A
E
S
D
V
S
T
A
I
D
L
F
R
Q
A
G
L
G
N
H
L
S
G
S
E
R
L
T
L
L
A
P
L
N
S
V
F
420
421
K
D
G
T
P
P
I
D
A
H
T
R
N
L
L
R
N
H
I
I
K
D
Q
L
A
S
K
Y
L
Y
H
G
Q
T
L
E
T
L
G
G
K
K
L
R
V
F
V
Y
R
N
S
L
C
I
E
N
S
C
I
A
480
481
A
H
D
K
R
G
R
Y
G
T
L
F
T
M
D
R
V
L
T
P
P
M
G
T
V
M
D
V
L
K
G
D
N
R
F
S
M
L
V
A
A
I
Q
S
A
G
L
T
E
T
L
N
R
E
G
V
Y
T
V
F
540
541
A
P
T
N
E
A
F
R
A
L
P
P
R
E
R
S
R
L
L
G
D
A
K
E
L
A
N
I
L
K
Y
H
I
G
D
E
I
L
V
S
G
G
I
G
A
L
V
R
L
K
S
L
Q
G
D
K
L
E
V
S
600
601
L
K
N
N
V
V
S
V
N
K
E
P
V
A
E
P
D
I
M
A
T
N
G
V
V
H
V
I
T
N
V
L
Q
P
P
A
N
R
P
Q
E
R
G
D
E
L
A
D
S
A
L
E
I
F
K
Q
A
S
A
F
660
661
S
R
A
S
Q
R
S
V
R
L
A
P
V
Y
Q
K
L
L
E
R
M
K
H
683
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1737
Peptide:
LGVVGSTTTQLYT
Length:
13
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
Q15582
UniProt Name:
BGH3_HUMAN
Protein Name:
Transforming growth factor-beta-induced protein ig-h3 (Beta ig-h3)
Position:
110-122
Literature
PMID:
12392546
Reference:
Eur J Biochem. 2002 Nov;269(21):5149-56.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
38.46
NuAPRpred:
-1.32
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
17.3
Area of the profile Above Threshold (AGGRESCAN):
3.43
Best Energy Score (PASTA 2.0):
-3.43
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1738 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1738
Peptide:
LSQPKIVKWDRDM
Length:
13
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
107-119
Literature
PMID:
12488093
Reference:
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
5
Hydrophobicity:
46.15
NuAPRpred:
-2.53
Tango:
0.0
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-30.0
Area of the profile Above Threshold (AGGRESCAN):
1.36
Best Energy Score (PASTA 2.0):
-3.54
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1739 Classification: Non-amyloid
CSV
JSON
Close ×
Sequence
1
M
S
R
S
V
A
L
A
V
L
A
L
L
S
L
S
G
L
E
A
I
Q
R
T
P
K
I
Q
V
Y
S
R
H
P
A
E
N
G
K
S
N
F
L
N
C
Y
V
S
G
F
H
P
S
D
I
E
V
D
L
L
60
61
K
N
G
E
R
I
E
K
V
E
H
S
D
L
S
F
S
K
D
W
S
F
Y
L
L
Y
Y
T
E
F
T
P
T
E
K
D
E
Y
A
C
R
V
N
H
V
T
L
S
Q
P
K
I
V
K
W
D
R
D
M
119
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1739
Peptide:
NGKSNFLNCYVSG
Length:
13
Classification:
Non-amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P61769
UniProt Name:
B2MG_HUMAN
Protein Name:
Beta-2-microglobulin
Position:
37-49
Literature
PMID:
12488093
Reference:
J Mol Biol. 2003 Jan 10;325(2):249-57., Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9771-6.
source:
AmyLoad
Derived Information
Net Charge:
1
Absolute Charge:
1
Hydrophobicity:
38.46
NuAPRpred:
2.9
Tango:
8.15
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
-0.1
Area of the profile Above Threshold (AGGRESCAN):
3.17
Best Energy Score (PASTA 2.0):
-4.13
Aggregate Orientation (PASTA 2.0):
Parallel
Entry: P-1740 Classification: Amyloid
CSV
JSON
Close ×
Sequence
1
M
V
A
G
T
R
C
L
L
A
L
L
L
P
Q
V
L
L
G
G
A
A
G
L
V
P
E
L
G
R
R
K
F
A
A
A
S
S
G
R
P
S
S
Q
P
S
D
E
V
L
S
E
F
E
L
R
L
L
S
M
60
61
F
G
L
K
Q
R
P
T
P
S
R
D
A
V
V
P
P
Y
M
L
D
L
Y
R
R
H
S
G
Q
P
G
S
P
A
P
D
H
R
L
E
R
A
A
S
R
A
N
T
V
R
S
F
H
H
E
E
S
L
E
E
120
121
L
P
E
T
S
G
K
T
T
R
R
F
F
F
N
L
S
S
I
P
T
E
E
F
I
T
S
A
E
L
Q
V
F
R
E
Q
M
Q
D
A
L
G
N
N
S
S
F
H
H
R
I
N
I
Y
E
I
I
K
P
A
180
181
T
A
N
S
K
F
P
V
T
R
L
L
D
T
R
L
V
N
Q
N
A
S
R
W
E
S
F
D
V
T
P
A
V
M
R
W
T
A
Q
G
H
A
N
H
G
F
V
V
E
V
A
H
L
E
E
K
Q
G
V
S
240
241
K
R
H
V
R
I
S
R
S
L
H
Q
D
E
H
S
W
S
Q
I
R
P
L
L
V
T
F
G
H
D
G
K
G
H
P
L
H
K
R
E
K
R
Q
A
K
H
K
Q
R
K
R
L
K
S
S
C
K
R
H
P
300
301
L
Y
V
D
F
S
D
V
G
W
N
D
W
I
V
A
P
P
G
Y
H
A
F
Y
C
H
G
E
C
P
F
P
L
A
D
H
L
N
S
T
N
H
A
I
V
Q
T
L
V
N
S
V
N
S
K
I
P
K
A
C
360
361
C
V
P
T
E
L
S
A
I
S
M
L
Y
L
D
E
N
E
K
V
V
L
K
N
Y
Q
D
M
V
V
E
G
C
G
C
R
396
Amyloidogenic/non-amyloidogenic residues are highlighed in green background.
Charged and Proline residues are highlighed in light red.
Peptide details
Entry:
P-1740
Peptide:
NHAIVQTLVNSVN
Length:
13
Classification:
Amyloid
Mutation(s):
No
Structure(s):
No structures
Protein Information
UniProt ID:
P12643
UniProt Name:
BMP2_HUMAN
Protein Name:
Bone morphogenetic protein 2 (BMP-2)
Position:
341-353
Literature
PMID:
18684013
Reference:
PLoS Biol. 2008 Aug 5;6(8):e195.
source:
CPAD
Derived Information
Net Charge:
0
Absolute Charge:
0
Hydrophobicity:
46.15
NuAPRpred:
3.09
Tango:
153.71
Derived Information (continued)
Normalized Aggregation Propensity (AGGRESCAN):
9.8
Area of the profile Above Threshold (AGGRESCAN):
3.28
Best Energy Score (PASTA 2.0):
-6.7
Aggregate Orientation (PASTA 2.0):
Parallel
